Long-term outcomes in patients with adult-onset craniopharyngioma
Purpose Craniopharyngiomas are nonmalignant sellar and parasellar tumors exhibiting a bimodal age distribution. While the outcomes following treatment in patients with childhood-onset craniopharyngiomas are well characterized, similar information in adult-onset craniopharyngiomas is limited. We aime...
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| Veröffentlicht in: | Endocrine 2022, Vol.78 (1), p.123-134 |
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| creator | Dogra, Prerna Bedatsova, Lucia Van Gompel, Jamie J. Giannini, Caterina Donegan, Diane M. Erickson, Dana |
| description | Purpose
Craniopharyngiomas are nonmalignant sellar and parasellar tumors exhibiting a bimodal age distribution. While the outcomes following treatment in patients with childhood-onset craniopharyngiomas are well characterized, similar information in adult-onset craniopharyngiomas is limited. We aimed to describe the long-term outcomes (weight and metabolic parameters, mortality) in patients with adult-onset craniopharyngioma following treatment.
Methods
Patients with adult-onset craniopharyngioma with initial treatment (1993–2017) and >6 months of follow-up at our institution were retrospectively identified. Body mass index (BMI) categories included obese (BMI ≥ 30 kg/m
2
), overweight (BMI 25–29.9 kg/m
2
), and normal weight (BMI |
| doi_str_mv | 10.1007/s12020-022-03134-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9308022</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2714728257</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-40792f994fb4f07cd451e146ad19b5dd4bdef0db9ef03c6c33c3de476713f96e3</originalsourceid><addsrcrecordid>eNp9kUtPAyEUhYnRWF9_wNUkbtygvGYoGxNjfCVN3OiaMMC0NDNQgdH470Xb-Fq4AcL97rnn5gBwjNEZRoifJ0wQQRARAhHFlEG2BfZwXQuISn37x3sC9lNaokKShu-CCa2njRCc7IHLWfBzmG0cqjBmHQabKuerlcrO-pyqV5cXlTJjn2HwyeZKR-VdWC1UfPNzFwZ1CHY61Sd7tLkPwNPN9ePVHZw93N5fXc6gZjXOkCEuSCcE61rWIa5N-bWYNcpg0dbGsNbYDplWlJPqRlOqqbGMNxzTTjSWHoCLte5qbAdrdLEXVS9X0Q3FiwzKyd8V7xZyHl6koGhaNi8CpxuBGJ5Hm7IcXNK275W3YUySNILyKeYcFfTkD7oMY_RlPUk4ZpxMSc0LRdaUjiGlaLsvMxjJj4TkOiFZpsvPhCQrTXTdlArs5zZ-S__T9Q5S5ZMh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2714728257</pqid></control><display><type>article</type><title>Long-term outcomes in patients with adult-onset craniopharyngioma</title><source>SpringerNature Journals</source><creator>Dogra, Prerna ; Bedatsova, Lucia ; Van Gompel, Jamie J. ; Giannini, Caterina ; Donegan, Diane M. ; Erickson, Dana</creator><creatorcontrib>Dogra, Prerna ; Bedatsova, Lucia ; Van Gompel, Jamie J. ; Giannini, Caterina ; Donegan, Diane M. ; Erickson, Dana</creatorcontrib><description>Purpose
Craniopharyngiomas are nonmalignant sellar and parasellar tumors exhibiting a bimodal age distribution. While the outcomes following treatment in patients with childhood-onset craniopharyngiomas are well characterized, similar information in adult-onset craniopharyngiomas is limited. We aimed to describe the long-term outcomes (weight and metabolic parameters, mortality) in patients with adult-onset craniopharyngioma following treatment.
Methods
Patients with adult-onset craniopharyngioma with initial treatment (1993–2017) and >6 months of follow-up at our institution were retrospectively identified. Body mass index (BMI) categories included obese (BMI ≥ 30 kg/m
2
), overweight (BMI 25–29.9 kg/m
2
), and normal weight (BMI < 25 kg/m
2
).
Results
For the 91 patients with adult-onset craniopharyngioma (44% women, mean diagnosis age 48.2 ± 18 years) over a mean follow-up of 100.3 ± 69.5 months, weight at last follow-up was significantly higher than before surgery (mean difference 9.5 ± 14.8 kg,
P
< 0.001) with a higher percentage increase in weight seen in those with lower preoperative BMI (normal weight (20.7 ± 18%) vs. overweight (13.3 ± 18.0%) vs. obese (6.4 ± 15%),
P
= 0.012). At last follow-up, the prevalence of obesity (62 vs. 40.5%,
P
= 0.0042) and impaired glucose metabolism (17.4% vs. 34%,
P
= 0.017) increased significantly. All-cause mortality was 12%, with the average age of death 71.9 ± 19.7 years (average U.S. life expectancy 77.7 years, CDC 2020).
Conclusion
Patients with adult-onset craniopharyngioma following treatment may experience weight gain, increased prevalence of obesity, impaired glucose metabolism, and early mortality. Lower preoperative BMI is associated with a greater percentage increase in postoperative weight.</description><identifier>ISSN: 1559-0100</identifier><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-022-03134-4</identifier><identifier>PMID: 35869972</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age composition ; Body mass index ; Body weight ; Body weight gain ; Children ; Diabetes ; Endocrinology ; Glucose metabolism ; Humanities and Social Sciences ; Internal Medicine ; Life span ; Medicine ; Medicine & Public Health ; Metabolism ; Mortality ; multidisciplinary ; Neoplasia ; Obesity ; Original ; Original Article ; Overweight ; Patients ; Pituitary ; Science ; Tumors</subject><ispartof>Endocrine, 2022, Vol.78 (1), p.123-134</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-40792f994fb4f07cd451e146ad19b5dd4bdef0db9ef03c6c33c3de476713f96e3</citedby><cites>FETCH-LOGICAL-c451t-40792f994fb4f07cd451e146ad19b5dd4bdef0db9ef03c6c33c3de476713f96e3</cites><orcidid>0000-0002-1842-1968</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-022-03134-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-022-03134-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Dogra, Prerna</creatorcontrib><creatorcontrib>Bedatsova, Lucia</creatorcontrib><creatorcontrib>Van Gompel, Jamie J.</creatorcontrib><creatorcontrib>Giannini, Caterina</creatorcontrib><creatorcontrib>Donegan, Diane M.</creatorcontrib><creatorcontrib>Erickson, Dana</creatorcontrib><title>Long-term outcomes in patients with adult-onset craniopharyngioma</title><title>Endocrine</title><addtitle>Endocrine</addtitle><description>Purpose
Craniopharyngiomas are nonmalignant sellar and parasellar tumors exhibiting a bimodal age distribution. While the outcomes following treatment in patients with childhood-onset craniopharyngiomas are well characterized, similar information in adult-onset craniopharyngiomas is limited. We aimed to describe the long-term outcomes (weight and metabolic parameters, mortality) in patients with adult-onset craniopharyngioma following treatment.
Methods
Patients with adult-onset craniopharyngioma with initial treatment (1993–2017) and >6 months of follow-up at our institution were retrospectively identified. Body mass index (BMI) categories included obese (BMI ≥ 30 kg/m
2
), overweight (BMI 25–29.9 kg/m
2
), and normal weight (BMI < 25 kg/m
2
).
Results
For the 91 patients with adult-onset craniopharyngioma (44% women, mean diagnosis age 48.2 ± 18 years) over a mean follow-up of 100.3 ± 69.5 months, weight at last follow-up was significantly higher than before surgery (mean difference 9.5 ± 14.8 kg,
P
< 0.001) with a higher percentage increase in weight seen in those with lower preoperative BMI (normal weight (20.7 ± 18%) vs. overweight (13.3 ± 18.0%) vs. obese (6.4 ± 15%),
P
= 0.012). At last follow-up, the prevalence of obesity (62 vs. 40.5%,
P
= 0.0042) and impaired glucose metabolism (17.4% vs. 34%,
P
= 0.017) increased significantly. All-cause mortality was 12%, with the average age of death 71.9 ± 19.7 years (average U.S. life expectancy 77.7 years, CDC 2020).
Conclusion
Patients with adult-onset craniopharyngioma following treatment may experience weight gain, increased prevalence of obesity, impaired glucose metabolism, and early mortality. Lower preoperative BMI is associated with a greater percentage increase in postoperative weight.</description><subject>Age composition</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Children</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Glucose metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Internal Medicine</subject><subject>Life span</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>multidisciplinary</subject><subject>Neoplasia</subject><subject>Obesity</subject><subject>Original</subject><subject>Original Article</subject><subject>Overweight</subject><subject>Patients</subject><subject>Pituitary</subject><subject>Science</subject><subject>Tumors</subject><issn>1559-0100</issn><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUtPAyEUhYnRWF9_wNUkbtygvGYoGxNjfCVN3OiaMMC0NDNQgdH470Xb-Fq4AcL97rnn5gBwjNEZRoifJ0wQQRARAhHFlEG2BfZwXQuISn37x3sC9lNaokKShu-CCa2njRCc7IHLWfBzmG0cqjBmHQabKuerlcrO-pyqV5cXlTJjn2HwyeZKR-VdWC1UfPNzFwZ1CHY61Sd7tLkPwNPN9ePVHZw93N5fXc6gZjXOkCEuSCcE61rWIa5N-bWYNcpg0dbGsNbYDplWlJPqRlOqqbGMNxzTTjSWHoCLte5qbAdrdLEXVS9X0Q3FiwzKyd8V7xZyHl6koGhaNi8CpxuBGJ5Hm7IcXNK275W3YUySNILyKeYcFfTkD7oMY_RlPUk4ZpxMSc0LRdaUjiGlaLsvMxjJj4TkOiFZpsvPhCQrTXTdlArs5zZ-S__T9Q5S5ZMh</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Dogra, Prerna</creator><creator>Bedatsova, Lucia</creator><creator>Van Gompel, Jamie J.</creator><creator>Giannini, Caterina</creator><creator>Donegan, Diane M.</creator><creator>Erickson, Dana</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1842-1968</orcidid></search><sort><creationdate>2022</creationdate><title>Long-term outcomes in patients with adult-onset craniopharyngioma</title><author>Dogra, Prerna ; Bedatsova, Lucia ; Van Gompel, Jamie J. ; Giannini, Caterina ; Donegan, Diane M. ; Erickson, Dana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-40792f994fb4f07cd451e146ad19b5dd4bdef0db9ef03c6c33c3de476713f96e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age composition</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Children</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Glucose metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Internal Medicine</topic><topic>Life span</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>multidisciplinary</topic><topic>Neoplasia</topic><topic>Obesity</topic><topic>Original</topic><topic>Original Article</topic><topic>Overweight</topic><topic>Patients</topic><topic>Pituitary</topic><topic>Science</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dogra, Prerna</creatorcontrib><creatorcontrib>Bedatsova, Lucia</creatorcontrib><creatorcontrib>Van Gompel, Jamie J.</creatorcontrib><creatorcontrib>Giannini, Caterina</creatorcontrib><creatorcontrib>Donegan, Diane M.</creatorcontrib><creatorcontrib>Erickson, Dana</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dogra, Prerna</au><au>Bedatsova, Lucia</au><au>Van Gompel, Jamie J.</au><au>Giannini, Caterina</au><au>Donegan, Diane M.</au><au>Erickson, Dana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term outcomes in patients with adult-onset craniopharyngioma</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><date>2022</date><risdate>2022</risdate><volume>78</volume><issue>1</issue><spage>123</spage><epage>134</epage><pages>123-134</pages><issn>1559-0100</issn><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
Craniopharyngiomas are nonmalignant sellar and parasellar tumors exhibiting a bimodal age distribution. While the outcomes following treatment in patients with childhood-onset craniopharyngiomas are well characterized, similar information in adult-onset craniopharyngiomas is limited. We aimed to describe the long-term outcomes (weight and metabolic parameters, mortality) in patients with adult-onset craniopharyngioma following treatment.
Methods
Patients with adult-onset craniopharyngioma with initial treatment (1993–2017) and >6 months of follow-up at our institution were retrospectively identified. Body mass index (BMI) categories included obese (BMI ≥ 30 kg/m
2
), overweight (BMI 25–29.9 kg/m
2
), and normal weight (BMI < 25 kg/m
2
).
Results
For the 91 patients with adult-onset craniopharyngioma (44% women, mean diagnosis age 48.2 ± 18 years) over a mean follow-up of 100.3 ± 69.5 months, weight at last follow-up was significantly higher than before surgery (mean difference 9.5 ± 14.8 kg,
P
< 0.001) with a higher percentage increase in weight seen in those with lower preoperative BMI (normal weight (20.7 ± 18%) vs. overweight (13.3 ± 18.0%) vs. obese (6.4 ± 15%),
P
= 0.012). At last follow-up, the prevalence of obesity (62 vs. 40.5%,
P
= 0.0042) and impaired glucose metabolism (17.4% vs. 34%,
P
= 0.017) increased significantly. All-cause mortality was 12%, with the average age of death 71.9 ± 19.7 years (average U.S. life expectancy 77.7 years, CDC 2020).
Conclusion
Patients with adult-onset craniopharyngioma following treatment may experience weight gain, increased prevalence of obesity, impaired glucose metabolism, and early mortality. Lower preoperative BMI is associated with a greater percentage increase in postoperative weight.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35869972</pmid><doi>10.1007/s12020-022-03134-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-1842-1968</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SpringerNature Journals |
| subjects | Age composition Body mass index Body weight Body weight gain Children Diabetes Endocrinology Glucose metabolism Humanities and Social Sciences Internal Medicine Life span Medicine Medicine & Public Health Metabolism Mortality multidisciplinary Neoplasia Obesity Original Original Article Overweight Patients Pituitary Science Tumors |
| title | Long-term outcomes in patients with adult-onset craniopharyngioma |
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