Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein

Lipoic acid is a sulfur-containing cofactor indispensable for the function of several metabolic enzymes. In microorganisms, lipoic acid can be salvaged from the surroundings by lipoate protein ligase A (LplA), an ATP-dependent enzyme. Alternatively, it can be synthesized by the sequential actions of...

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Veröffentlicht in:	The Journal of biological chemistry 2022-08, Vol.298 (8), p.102203-102203, Article 102203
Hauptverfasser:	Dhembla, Chetna, Yadav, Usha, Kundu, Suman, Sundd, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	ACP acyl carrier protein C8-CoA CoA glycine cleavage system H protein lipoate protein ligase B lipoic acid synthesis NMR
Online-Zugang:	Volltext
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