Analysis of potential anti-aging beverage Pru, a traditional Cuban refreshment, by desorption electrospray ionization-mass spectrometry and FTICR tandem mass spectrometry
Aging has been established as a major risk factor for prevalent diseases and hence, the development of anti-aging medicines is of great importance. Recently, herbal fermented beverages have emerged as a promising source of potential anti-aging drug. Pru, a traditional Cuban refreshment produced by d...
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| Veröffentlicht in: | Journal of food and drug analysis 2019-10, Vol.27 (4), p.833-840 |
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| creator | Mamun, Md. Al Gonzalez, Tania Valdes Islam, Ariful Sato, Tomohito Sato, Shumpei Ito, Takashi K. Horikawa, Makoto Yamazaki, Fumiyoshi Alarcon, Rolando Contreras Ido, Tatsuo Setou, Mitsutoshi |
| description | Aging has been established as a major risk factor for prevalent diseases and hence, the development of anti-aging medicines is of great importance. Recently, herbal fermented beverages have emerged as a promising source of potential anti-aging drug. Pru, a traditional Cuban refreshment produced by decoction and fermentation of multispecies plants with sugar, has been consumed for many years and is claimed to have multiple medicinal properties. Besides the traditional method, Pru is also manufactured industrially. The present study analyzed the major components of both traditional Pru (TP) and industrial Pru (IP) to reveal their potential application in promoting the health span. We performed desorption electrospray ionization-mass spectrometry (DESI-MS) and acquired mass spectra by scanning over the 50–1200 m/z range in both positive and negative ion modes. Fourier transform ion cyclotron resonance (FTICR) tandem mass spectrometry (MS/MS) was performed for validating the compound assignments. Three important compounds were identified by comparing the MS and MS/MS spectra with reported literature and the online database. One of the identified compounds, gluconic acid, was found to be the most abundant shared metabolite between TP and IP whereas the other two compounds, magnoflorine and levan were exclusively detected in TP. The present study is the first report of component profiling in Cuban traditional and industrial Pru using DESI-MS and FTICR MS/MS, and reveals the potential application of Pru as a health-promoting agent.
[Display omitted]
•Pru, a Cuban Traditional beverage, is produced both traditionally and industrially and claimed to have medicinal properties.•DESI-MS and FTICR MS/MS analyses revealed major components of Pru.•Gluconic acid was found to be the most abundant shared metabolite between traditional and industrial Pru.•Two compounds, magnoflorine and levan were exclusively detected in traditional Pru.•All of the detected compounds are well known to have beneficial health effects. |
| doi_str_mv | 10.1016/j.jfda.2019.05.004 |
| format | Article |
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[Display omitted]
•Pru, a Cuban Traditional beverage, is produced both traditionally and industrially and claimed to have medicinal properties.•DESI-MS and FTICR MS/MS analyses revealed major components of Pru.•Gluconic acid was found to be the most abundant shared metabolite between traditional and industrial Pru.•Two compounds, magnoflorine and levan were exclusively detected in traditional Pru.•All of the detected compounds are well known to have beneficial health effects.</description><identifier>ISSN: 1021-9498</identifier><identifier>EISSN: 2224-6614</identifier><identifier>DOI: 10.1016/j.jfda.2019.05.004</identifier><identifier>PMID: 31590754</identifier><language>eng</language><publisher>China (Republic : 1949- ): Elsevier Taiwan LLC</publisher><subject>Aging ; Aging - drug effects ; Anti-aging ; Beverages ; Beverages - analysis ; Cuban traditional beverage ; Cyclotron resonance ; DESI-MS ; Desorption ; Electrospraying ; Experiments ; Fermentation ; Fourier transforms ; FTICR MS/MS ; Gluconic acid ; Health promotion ; Health risks ; Humans ; Ionization ; Ions ; Levan ; Mass spectra ; Mass spectrometry ; Mass spectroscopy ; Medicine, Traditional ; Metabolites ; Negative ions ; Original ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Pru ; Risk analysis ; Risk factors ; Scientific imaging ; Software ; Solvents ; Spectrometry, Mass, Electrospray Ionization ; Spectroscopy ; Sugar ; Tandem Mass Spectrometry</subject><ispartof>Journal of food and drug analysis, 2019-10, Vol.27 (4), p.833-840</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Taiwan LLC.</rights><rights>Copyright Elsevier Limited Oct 2019</rights><rights>2019 Taiwan Food and Drug Administration 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-e075867dee33ddeef7cc1beb76e9a63b316375614751806c3c03c254f236252a3</citedby><cites>FETCH-LOGICAL-c549t-e075867dee33ddeef7cc1beb76e9a63b316375614751806c3c03c254f236252a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306984/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306984/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31590754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mamun, Md. Al</creatorcontrib><creatorcontrib>Gonzalez, Tania Valdes</creatorcontrib><creatorcontrib>Islam, Ariful</creatorcontrib><creatorcontrib>Sato, Tomohito</creatorcontrib><creatorcontrib>Sato, Shumpei</creatorcontrib><creatorcontrib>Ito, Takashi K.</creatorcontrib><creatorcontrib>Horikawa, Makoto</creatorcontrib><creatorcontrib>Yamazaki, Fumiyoshi</creatorcontrib><creatorcontrib>Alarcon, Rolando Contreras</creatorcontrib><creatorcontrib>Ido, Tatsuo</creatorcontrib><creatorcontrib>Setou, Mitsutoshi</creatorcontrib><title>Analysis of potential anti-aging beverage Pru, a traditional Cuban refreshment, by desorption electrospray ionization-mass spectrometry and FTICR tandem mass spectrometry</title><title>Journal of food and drug analysis</title><addtitle>J Food Drug Anal</addtitle><description>Aging has been established as a major risk factor for prevalent diseases and hence, the development of anti-aging medicines is of great importance. Recently, herbal fermented beverages have emerged as a promising source of potential anti-aging drug. Pru, a traditional Cuban refreshment produced by decoction and fermentation of multispecies plants with sugar, has been consumed for many years and is claimed to have multiple medicinal properties. Besides the traditional method, Pru is also manufactured industrially. The present study analyzed the major components of both traditional Pru (TP) and industrial Pru (IP) to reveal their potential application in promoting the health span. We performed desorption electrospray ionization-mass spectrometry (DESI-MS) and acquired mass spectra by scanning over the 50–1200 m/z range in both positive and negative ion modes. Fourier transform ion cyclotron resonance (FTICR) tandem mass spectrometry (MS/MS) was performed for validating the compound assignments. Three important compounds were identified by comparing the MS and MS/MS spectra with reported literature and the online database. One of the identified compounds, gluconic acid, was found to be the most abundant shared metabolite between TP and IP whereas the other two compounds, magnoflorine and levan were exclusively detected in TP. The present study is the first report of component profiling in Cuban traditional and industrial Pru using DESI-MS and FTICR MS/MS, and reveals the potential application of Pru as a health-promoting agent.
[Display omitted]
•Pru, a Cuban Traditional beverage, is produced both traditionally and industrially and claimed to have medicinal properties.•DESI-MS and FTICR MS/MS analyses revealed major components of Pru.•Gluconic acid was found to be the most abundant shared metabolite between traditional and industrial Pru.•Two compounds, magnoflorine and levan were exclusively detected in traditional Pru.•All of the detected compounds are well known to have beneficial health effects.</description><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Anti-aging</subject><subject>Beverages</subject><subject>Beverages - analysis</subject><subject>Cuban traditional beverage</subject><subject>Cyclotron resonance</subject><subject>DESI-MS</subject><subject>Desorption</subject><subject>Electrospraying</subject><subject>Experiments</subject><subject>Fermentation</subject><subject>Fourier transforms</subject><subject>FTICR MS/MS</subject><subject>Gluconic acid</subject><subject>Health promotion</subject><subject>Health risks</subject><subject>Humans</subject><subject>Ionization</subject><subject>Ions</subject><subject>Levan</subject><subject>Mass spectra</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicine, Traditional</subject><subject>Metabolites</subject><subject>Negative ions</subject><subject>Original</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Pru</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Scientific imaging</subject><subject>Software</subject><subject>Solvents</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Spectroscopy</subject><subject>Sugar</subject><subject>Tandem Mass Spectrometry</subject><issn>1021-9498</issn><issn>2224-6614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kl2L1DAUhoso7rj6B7yQgDdebMd8NOkEZGEZXF1YUGS9Dml6OpvSNjVpB-pP8ld6Zmdd_ABvknDOc97kvDlZ9pLRNaNMvW3XbVPbNadMr6lcU1o8ylac8yJXihWPsxWjnOW60JuT7FlKLaVKCs2fZieCSU1LWayyHxeD7ZbkEwkNGcMEw-RtRyxuud35YUcq2EO0OyCf43xGLJmirf3kA9aR7VzZgURoIqTbHmvPSLWQGlKI4wEh0IGbYkhjtAvBgP9uD_G8tymRNN4le5jigjfW5PLmavuFTHiEnvyDPM-eNLZL8OJ-P82-Xr6_2X7Mrz99uNpeXOdOFnrKARvbqLIGEKLGtSmdYxVUpQJtlagEU6KUaFAp2YYqJxwVjsui4UJxya04zc6PuuNc9VA7bCvazozR9zYuJlhv_swM_tbswt5oQZXeFCjw5l4ghm8zpMn0PjnoOjtAmJPhgvKiFFqXiL7-C23DHNHaO4pqvtGSIsWPlEMrE9r98BhGzWEUTGsOo2AOo2CoNDgKWPTq9zYeSn79PQLvjgCgmXsP0STnYXBQ-4iumzr4_-n_BIMjyaM</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Mamun, Md. 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Al ; Gonzalez, Tania Valdes ; Islam, Ariful ; Sato, Tomohito ; Sato, Shumpei ; Ito, Takashi K. ; Horikawa, Makoto ; Yamazaki, Fumiyoshi ; Alarcon, Rolando Contreras ; Ido, Tatsuo ; Setou, Mitsutoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-e075867dee33ddeef7cc1beb76e9a63b316375614751806c3c03c254f236252a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aging</topic><topic>Aging - drug effects</topic><topic>Anti-aging</topic><topic>Beverages</topic><topic>Beverages - analysis</topic><topic>Cuban traditional beverage</topic><topic>Cyclotron resonance</topic><topic>DESI-MS</topic><topic>Desorption</topic><topic>Electrospraying</topic><topic>Experiments</topic><topic>Fermentation</topic><topic>Fourier transforms</topic><topic>FTICR MS/MS</topic><topic>Gluconic acid</topic><topic>Health promotion</topic><topic>Health risks</topic><topic>Humans</topic><topic>Ionization</topic><topic>Ions</topic><topic>Levan</topic><topic>Mass spectra</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medicine, Traditional</topic><topic>Metabolites</topic><topic>Negative ions</topic><topic>Original</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Pru</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Scientific imaging</topic><topic>Software</topic><topic>Solvents</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Spectroscopy</topic><topic>Sugar</topic><topic>Tandem Mass Spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mamun, Md. Al</creatorcontrib><creatorcontrib>Gonzalez, Tania Valdes</creatorcontrib><creatorcontrib>Islam, Ariful</creatorcontrib><creatorcontrib>Sato, Tomohito</creatorcontrib><creatorcontrib>Sato, Shumpei</creatorcontrib><creatorcontrib>Ito, Takashi K.</creatorcontrib><creatorcontrib>Horikawa, Makoto</creatorcontrib><creatorcontrib>Yamazaki, Fumiyoshi</creatorcontrib><creatorcontrib>Alarcon, Rolando Contreras</creatorcontrib><creatorcontrib>Ido, Tatsuo</creatorcontrib><creatorcontrib>Setou, Mitsutoshi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of food and drug analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mamun, Md. Al</au><au>Gonzalez, Tania Valdes</au><au>Islam, Ariful</au><au>Sato, Tomohito</au><au>Sato, Shumpei</au><au>Ito, Takashi K.</au><au>Horikawa, Makoto</au><au>Yamazaki, Fumiyoshi</au><au>Alarcon, Rolando Contreras</au><au>Ido, Tatsuo</au><au>Setou, Mitsutoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of potential anti-aging beverage Pru, a traditional Cuban refreshment, by desorption electrospray ionization-mass spectrometry and FTICR tandem mass spectrometry</atitle><jtitle>Journal of food and drug analysis</jtitle><addtitle>J Food Drug Anal</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>27</volume><issue>4</issue><spage>833</spage><epage>840</epage><pages>833-840</pages><issn>1021-9498</issn><eissn>2224-6614</eissn><abstract>Aging has been established as a major risk factor for prevalent diseases and hence, the development of anti-aging medicines is of great importance. Recently, herbal fermented beverages have emerged as a promising source of potential anti-aging drug. Pru, a traditional Cuban refreshment produced by decoction and fermentation of multispecies plants with sugar, has been consumed for many years and is claimed to have multiple medicinal properties. Besides the traditional method, Pru is also manufactured industrially. The present study analyzed the major components of both traditional Pru (TP) and industrial Pru (IP) to reveal their potential application in promoting the health span. We performed desorption electrospray ionization-mass spectrometry (DESI-MS) and acquired mass spectra by scanning over the 50–1200 m/z range in both positive and negative ion modes. Fourier transform ion cyclotron resonance (FTICR) tandem mass spectrometry (MS/MS) was performed for validating the compound assignments. Three important compounds were identified by comparing the MS and MS/MS spectra with reported literature and the online database. One of the identified compounds, gluconic acid, was found to be the most abundant shared metabolite between TP and IP whereas the other two compounds, magnoflorine and levan were exclusively detected in TP. The present study is the first report of component profiling in Cuban traditional and industrial Pru using DESI-MS and FTICR MS/MS, and reveals the potential application of Pru as a health-promoting agent.
[Display omitted]
•Pru, a Cuban Traditional beverage, is produced both traditionally and industrially and claimed to have medicinal properties.•DESI-MS and FTICR MS/MS analyses revealed major components of Pru.•Gluconic acid was found to be the most abundant shared metabolite between traditional and industrial Pru.•Two compounds, magnoflorine and levan were exclusively detected in traditional Pru.•All of the detected compounds are well known to have beneficial health effects.</abstract><cop>China (Republic : 1949- )</cop><pub>Elsevier Taiwan LLC</pub><pmid>31590754</pmid><doi>10.1016/j.jfda.2019.05.004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of food and drug analysis, 2019-10, Vol.27 (4), p.833-840 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Aging Aging - drug effects Anti-aging Beverages Beverages - analysis Cuban traditional beverage Cyclotron resonance DESI-MS Desorption Electrospraying Experiments Fermentation Fourier transforms FTICR MS/MS Gluconic acid Health promotion Health risks Humans Ionization Ions Levan Mass spectra Mass spectrometry Mass spectroscopy Medicine, Traditional Metabolites Negative ions Original Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Pru Risk analysis Risk factors Scientific imaging Software Solvents Spectrometry, Mass, Electrospray Ionization Spectroscopy Sugar Tandem Mass Spectrometry |
| title | Analysis of potential anti-aging beverage Pru, a traditional Cuban refreshment, by desorption electrospray ionization-mass spectrometry and FTICR tandem mass spectrometry |
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