Evolution of new enzymes by gene duplication and divergence

Thousands of new metabolic and regulatory enzymes have evolved by gene duplication and divergence since the dawn of life. New enzyme activities often originate from promiscuous secondary activities that have become important for fitness due to a change in the environment or a mutation. Mutations tha...

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Veröffentlicht in:	The FEBS journal 2020-04, Vol.287 (7), p.1262-1283
1. Verfasser:	Copley, Shelley D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminohydrolases - genetics Aminohydrolases - metabolism Amplification Biological evolution directed evolution Divergence Enzymatic activity enzyme evolution Enzymes Evolution, Molecular Gene Duplication Genomes Hydrolases - genetics Hydrolases - metabolism Innovation–amplification–divergence model Mutation Oxidoreductases - genetics Oxidoreductases - metabolism promiscuity Reproduction (copying) Substrates
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