Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway

Viruses exploit the host lipid metabolism machinery to achieve efficient replication. We herein characterize the lipids profile reprogramming in vitro and in vivo using liquid chromatography-mass spectrometry-based untargeted lipidomics. The lipidome of SARS-CoV-2-infected Caco-2 cells was markedly...

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Veröffentlicht in:	International journal of biological sciences 2022-01, Vol.18 (12), p.4744-4755
Hauptverfasser:	Yan, Bingpeng, Yuan, Shuofeng, Cao, Jianli, Fung, Kingchun, Lai, Pok-Man, Yin, Feifei, Sze, Kong-Hung, Qin, Zhenzhi, Xie, Yubin, Ye, Zi-Wei, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Zou, Zijiao, Chan, Chris Chun-Yiu, Luo, Cuiting, Cai, Jian-Piao, Chan, Kwok-Hung, Chung, Tom Wai-Hing, Tam, Anthony Raymond, Chu, Hin, Jin, Dong-Yan, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Kao, Richard Yi-Tsun, Chan, Jasper Fuk-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase Coronaviruses COVID-19 Lipid metabolism Lipids Liquid chromatography Mass spectrometry Mass spectroscopy Phosphatidic acid Phosphatidylethanolamine Replication Research Paper Severe acute respiratory syndrome coronavirus 2 siRNA Viral diseases Viruses
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