Yoda1's energetic footprint on Piezo1 channels and its modulation by voltage and temperature

Piezo1 channels are essential mechanically activated ion channels in vertebrates. Their selective activation by the synthetic chemical activator Yoda1 opened new avenues to probe their gating mechanisms and develop novel pharmaceuticals. Yet, the nature and extent of Piezo1 functions modulated by th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-07, Vol.119 (29), p.e2202269119
Hauptverfasser:	Wijerathne, Tharaka D, Ozkan, Alper D, Lacroix, Jérôme J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Calcium imaging Channel gating Dwell time Ion channels Ion Channels - agonists Ion Channels - metabolism Kinetics Mammalian cells Mechanotransduction, Cellular - physiology Membrane potential Membrane Potentials Mice Modulation Modulators Pyrazines - pharmacology Temperature Thiadiazoles - pharmacology Vertebrates
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