Pharmacologic modulation of intracellular Na⁺ concentration with ranolazine impacts inflammatory response in humans and mice

Changes in Ca2⁺ influx during proinflammatory stimulation modulates cellular responses, including the subsequent activation of inflammation. Whereas the involvement of Ca2+ has been widely acknowledged, little is known about the role of Na⁺. Ranolazine, a piperazine derivative and established antian...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-07, Vol.119 (29), p.1-9
Hauptverfasser:	Lenz, Max, Salzmann, Manuel, Ciotu, Cosmin I., Kaun, Christoph, Krychtiuk, Konstantin A., Likozar, Andreja Rehberger, Sebestjen, Miran, Goederle, Laura, Rauscher, Sabine, Krivaja, Zoriza, Binder, Christoph J., Huber, Kurt, Hengstenberg, Christian, Podesser, Bruno K., Fischer, Michael J. M., Wojta, Johann, Hohensinnerb, Philipp J., Speidl, Walter S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Arteriosclerosis Atherosclerosis Biological Sciences C-reactive protein Calcium influx Calcium ions Cardiovascular disease Coronary artery Coronary artery disease Cytokines Endothelial cells Endothelium Heart diseases High fat diet Immune system Inflammation Inflammatory response Intracellular Leukocytes Low density lipoprotein Modulation Patients Pharmacology Piperazine Sodium
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