Serum/glucocorticoid‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activated T cell nuclear factor transcription factor 2

Bladder outlet obstruction (BOO) is a type of chronic disease that is mainly caused by benign prostatic hyperplasia. Previous studies discovered the involvements of both serum/glucocorticoid‐regulated kinase 1 (SGK1) and activated T cell nuclear factor transcription factor 2 (NFAT2) in the prolifera...

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Veröffentlicht in:	IUBMB life 2022-05, Vol.74 (5), p.463-473
Hauptverfasser:	He, Jiangshu, Yang, Jin, Chen, Lin, He, Pinglin, Liu, Xun, Wang, Kai, Dong, Taotao, Li, Jia, Ma, Xudong, Bastian, Amend, Arnulf, Stenzl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bladder bladder outlet obstruction bladder smooth muscle Capsaicin receptors Cell growth Cell Proliferation Chronic illnesses Collagen Collagen - metabolism collagen deposition Dexamethasone Dexamethasone - metabolism Dexamethasone - pharmacology Female Glucocorticoids Glucocorticoids - metabolism Humans Hyperplasia Immediate-Early Proteins - metabolism Immunohistochemistry Kinases Lymphocytes T Male Mice Mice, Inbred BALB C Myocytes, Smooth Muscle - metabolism NF-AT protein NFATC Transcription Factors - metabolism Oxalates - metabolism Oxalic acid Polymerase chain reaction Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Protein Serine-Threonine Kinases - metabolism Receptors, Glucocorticoid - metabolism Research Communication Research Communications Signal transduction siRNA Smooth muscle T-Lymphocytes - metabolism TCF Transcription Factors - metabolism Therapeutic targets Transcription factors Transient receptor potential proteins TRPV Cation Channels - metabolism TRPV1 Urethra Urinary Bladder - metabolism Urinary Bladder Neck Obstruction - drug therapy Urinary Bladder Neck Obstruction - genetics Urinary Bladder Neck Obstruction - metabolism Western blotting
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