SLCO1B15 Allele Is Associated With Atorvastatin Discontinuation and Adverse Muscle Symptoms in the Context of Routine Care

The SLCO1B1 genotype is known to influence patient adherence to statin therapy, in part by increasing the risk for statin‐associated musculoskeletal symptoms (SAMSs). The SLCO1B1*5 allele has previously been associated with simvastatin discontinuation and SAMSs. Prior analyses of the relationship be...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2022-05, Vol.111 (5), p.1075-1083
Hauptverfasser:	Voora, Deepak, Baye, Jordan, McDermaid, Adam, Narayana Gowda, Smitha, Wilke, Russell A., Nicole Myrmoe, Anna, Hajek, Catherine, Larson, Eric A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Atorvastatin - adverse effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Liver-Specific Organic Anion Transporter 1 - genetics Muscles Polymorphism, Single Nucleotide Pyrroles - therapeutic use Simvastatin - adverse effects
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