Bacterial growth dynamics and pharmacokinetic–pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice

Background and Purpose Translational efforts in the evaluation of novel anti‐tubercular drugs demand better integration of pharmacokinetic–pharmacodynamic data arising from preclinical protocols. However, parametric approaches that discriminate drug effect from the underlying bacterial growth dynami...

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Veröffentlicht in:	British journal of pharmacology 2022-03, Vol.179 (6), p.1251-1263
Hauptverfasser:	Muliaditan, Morris, Della Pasqua, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria bedaquiline Diarylquinolines - pharmacology human dose selection Mice Mice, Inbred BALB C Pharmacodynamics Pharmacokinetics PKPD modelling rifampicin Rifampin Rifampin - pharmacology translational pharmacology tuberculosis
Online-Zugang:	Volltext
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