Ablation of Growth Hormone Receptor in GABAergic Neurons Leads to Increased Pulsatile Growth Hormone Secretion

Growth hormone (GH) acts in several hypothalamic neuronal populations to modulate metabolism and the autoregulation of GH secretion via negative-feedback loops. However, few studies have investigated whether GH receptor (GHR) expression in specific neuronal populations is required for the homeostati...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2022-08, Vol.163 (8), p.1
Hauptverfasser:	dos Santos, Willian O, Wasinski, Frederick, Tavares, Mariana R, Campos, Ana M P, Elias, Carol F, List, Edward O, Kopchick, John J, Szawka, Raphael E, Donato, Jose
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Blood levels Blood sugar Body mass Body weight Brain Control theory Endocrinology Energy balance Feedback Feedback loops Female Females Food Food availability Food consumption Food intake GABA GABAergic Neurons Glucose Glutamatergic transmission Growth factors Growth Hormone - metabolism Growth hormone-releasing hormone Growth hormones Homeostasis Hypothalamus Hypothalamus - metabolism Insulin Insulin-like growth factor I Lean body mass Leptin Male Males Metabolism Mice Mice, Knockout mRNA Neuroendocrine system Neurons Oxygen consumption Phenotypes Populations Receptors Receptors, Leptin - metabolism Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism RNA Secretion Somatotropin Somatotropin releasing hormone Statistics Weight loss γ-Aminobutyric acid
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