Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-10, Vol.374 (6566), p.472-478
Hauptverfasser:	Hastie, Kathryn M, Li, Haoyang, Bedinger, Daniel, Schendel, Sharon L, Dennison, S Moses, Li, Kan, Rayaprolu, Vamseedhar, Yu, Xiaoying, Mann, Colin, Zandonatti, Michelle, Diaz Avalos, Ruben, Zyla, Dawid, Buck, Tierra, Hui, Sean, Shaffer, Kelly, Hariharan, Chitra, Yin, Jieyun, Olmedillas, Eduardo, Enriquez, Adrian, Parekh, Diptiben, Abraha, Milite, Feeney, Elizabeth, Horn, Gillian Q, Aldon, Yoann, Ali, Hanif, Aracic, Sanja, Cobb, Ronald R, Federman, Ross S, Fernandez, Joseph M, Glanville, Jacob, Green, Robin, Grigoryan, Gevorg, Lujan Hernandez, Ana G, Ho, David D, Huang, Kuan-Ying A, Ingraham, John, Jiang, Weidong, Kellam, Paul, Kim, Cheolmin, Kim, Minsoo, Kim, Hyeong Mi, Kong, Chao, Krebs, Shelly J, Lan, Fei, Lang, Guojun, Lee, Sooyoung, Leung, Cheuk Lun, Liu, Junli, Lu, Yanan, MacCamy, Anna, McGuire, Andrew T, Palser, Anne L, Rabbitts, Terence H, Rikhtegaran Tehrani, Zahra, Sajadi, Mohammad M, Sanders, Rogier W, Sato, Aaron K, Schweizer, Liang, Seo, Jimin, Shen, Bingqing, Snitselaar, Jonne L, Stamatatos, Leonidas, Tan, Yongcong, Tomic, Milan T, van Gils, Marit J, Youssef, Sawsan, Yu, Jian, Yuan, Tom Z, Zhang, Qian, Peters, Bjoern, Tomaras, Georgia D, Germann, Timothy, Saphire, Erica Ollmann
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Antibodies, Viral - immunology Antibodies, Viral - therapeutic use Antigens, Viral - chemistry Antigens, Viral - immunology Binding Community Relations Competition Consortia Coronaviruses COVID-19 COVID-19 - therapy COVID-19 vaccines Disease transmission Domains Epitope Mapping Epitopes Humans Immunodominant Epitopes - chemistry Immunodominant Epitopes - immunology Infections Monoclonal antibodies Morbidity Mutation Neutralization Prevention Protein Binding Protein Domains Proteins Receptors Respiratory diseases SARS-CoV-2 - immunology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology Spike protein Vaccines Viral diseases
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