The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome
Objective: This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically.Subject and methods: Peripheral blood samples were collected from a total of 200 people, including 100 acu...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-06, Vol.14 (6), p.e26147-e26147 |
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| creator | Kemanci, Aykut Goren, Tarik Uluturk, Mehmet Yilmaz, Atakan Sabirli, Ramazan Ozen, Mert Seyit, Murat Oskay, Alten Koseler, Aylin Turkcuer, Ibrahim |
| description | Objective: This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically.Subject and methods: Peripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed.Results: PPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p |
| doi_str_mv | 10.7759/cureus.26147 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9301886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2695285027</sourcerecordid><originalsourceid>FETCH-LOGICAL-c276t-93d3b811c9eb8857a8f4fbe1ae494d9c73ea73d11ae250e7b681868929acf50c3</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhi1ERau2N36AJS4cSPFH4o8L0rKCglSpKyhny3EmrKvEDnZSWKk_vu5uhSinGb3z6J0ZvQi9puRCyka_d0uCJV8wQWv5Ap0wKlSlqKpf_tMfo_OcbwkhlEhGJHmFjnmjNFVcnKD7my3gdUwJBjv7GPBHmH8DBLyBFP_4HEfAmxQH30Oyc0zVys3-zs7Q4W_gYCoSXg3T1mIbOnxpx9HiTRx2Y0zT1ucx7_WVW-b9mhhs2uHvu9Cl4nyGjno7ZDh_qqfox-dPN-sv1dX15df16qpyTIq50rzjraLUaWiVaqRVfd23QC3Uuu60kxys5B0tAmsIyFaUt4XSTFvXN8TxU_Th4Dst7QidgzAnO5gp-bGcY6L15vkk-K35Ge-M5oQqJYrB2yeDFH8tkGcz-uxgGGyAuGTDhG6YagiTBX3zH3oblxTKe4-UkEqShhbq3YFyKeacoP97DCXmMVlzSNbsk-UPjAKZLg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2696787051</pqid></control><display><type>article</type><title>The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome</title><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Kemanci, Aykut ; Goren, Tarik ; Uluturk, Mehmet ; Yilmaz, Atakan ; Sabirli, Ramazan ; Ozen, Mert ; Seyit, Murat ; Oskay, Alten ; Koseler, Aylin ; Turkcuer, Ibrahim</creator><creatorcontrib>Kemanci, Aykut ; Goren, Tarik ; Uluturk, Mehmet ; Yilmaz, Atakan ; Sabirli, Ramazan ; Ozen, Mert ; Seyit, Murat ; Oskay, Alten ; Koseler, Aylin ; Turkcuer, Ibrahim</creatorcontrib><description>Objective: This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically.Subject and methods: Peripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed.Results: PPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p<0.01).Conclusion: The findings revealed that elevated PPAR alpha L162V and PPAR gamma C161T gene polymorphisms were associated with a progressive risk of ACS.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.26147</identifier><identifier>PMID: 35891836</identifier><language>eng</language><publisher>Palo Alto: Cureus Inc</publisher><subject>Acute coronary syndromes ; Angina pectoris ; Apolipoproteins ; Atherosclerosis ; Blood pressure ; Cardiology ; Cardiovascular disease ; Cholesterol ; Coronary vessels ; Cytokines ; Emergency Medicine ; Genetics ; Glucose ; Heart attacks ; High density lipoprotein ; Hypertension ; Kinases ; Lipids ; Lipoproteins ; Metabolism ; Patients ; Polymorphism ; Smooth muscle ; Software ; Thrombosis</subject><ispartof>Curēus (Palo Alto, CA), 2022-06, Vol.14 (6), p.e26147-e26147</ispartof><rights>Copyright © 2022, Kemanci et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Kemanci et al. 2022 Kemanci et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c276t-93d3b811c9eb8857a8f4fbe1ae494d9c73ea73d11ae250e7b681868929acf50c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301886/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301886/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Kemanci, Aykut</creatorcontrib><creatorcontrib>Goren, Tarik</creatorcontrib><creatorcontrib>Uluturk, Mehmet</creatorcontrib><creatorcontrib>Yilmaz, Atakan</creatorcontrib><creatorcontrib>Sabirli, Ramazan</creatorcontrib><creatorcontrib>Ozen, Mert</creatorcontrib><creatorcontrib>Seyit, Murat</creatorcontrib><creatorcontrib>Oskay, Alten</creatorcontrib><creatorcontrib>Koseler, Aylin</creatorcontrib><creatorcontrib>Turkcuer, Ibrahim</creatorcontrib><title>The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome</title><title>Curēus (Palo Alto, CA)</title><description>Objective: This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically.Subject and methods: Peripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed.Results: PPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p<0.01).Conclusion: The findings revealed that elevated PPAR alpha L162V and PPAR gamma C161T gene polymorphisms were associated with a progressive risk of ACS.</description><subject>Acute coronary syndromes</subject><subject>Angina pectoris</subject><subject>Apolipoproteins</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Emergency Medicine</subject><subject>Genetics</subject><subject>Glucose</subject><subject>Heart attacks</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Metabolism</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Smooth muscle</subject><subject>Software</subject><subject>Thrombosis</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU1v1DAQhi1ERau2N36AJS4cSPFH4o8L0rKCglSpKyhny3EmrKvEDnZSWKk_vu5uhSinGb3z6J0ZvQi9puRCyka_d0uCJV8wQWv5Ap0wKlSlqKpf_tMfo_OcbwkhlEhGJHmFjnmjNFVcnKD7my3gdUwJBjv7GPBHmH8DBLyBFP_4HEfAmxQH30Oyc0zVys3-zs7Q4W_gYCoSXg3T1mIbOnxpx9HiTRx2Y0zT1ucx7_WVW-b9mhhs2uHvu9Cl4nyGjno7ZDh_qqfox-dPN-sv1dX15df16qpyTIq50rzjraLUaWiVaqRVfd23QC3Uuu60kxys5B0tAmsIyFaUt4XSTFvXN8TxU_Th4Dst7QidgzAnO5gp-bGcY6L15vkk-K35Ge-M5oQqJYrB2yeDFH8tkGcz-uxgGGyAuGTDhG6YagiTBX3zH3oblxTKe4-UkEqShhbq3YFyKeacoP97DCXmMVlzSNbsk-UPjAKZLg</recordid><startdate>20220621</startdate><enddate>20220621</enddate><creator>Kemanci, Aykut</creator><creator>Goren, Tarik</creator><creator>Uluturk, Mehmet</creator><creator>Yilmaz, Atakan</creator><creator>Sabirli, Ramazan</creator><creator>Ozen, Mert</creator><creator>Seyit, Murat</creator><creator>Oskay, Alten</creator><creator>Koseler, Aylin</creator><creator>Turkcuer, Ibrahim</creator><general>Cureus Inc</general><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220621</creationdate><title>The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome</title><author>Kemanci, Aykut ; Goren, Tarik ; Uluturk, Mehmet ; Yilmaz, Atakan ; Sabirli, Ramazan ; Ozen, Mert ; Seyit, Murat ; Oskay, Alten ; Koseler, Aylin ; Turkcuer, Ibrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-93d3b811c9eb8857a8f4fbe1ae494d9c73ea73d11ae250e7b681868929acf50c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute coronary syndromes</topic><topic>Angina pectoris</topic><topic>Apolipoproteins</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Coronary vessels</topic><topic>Cytokines</topic><topic>Emergency Medicine</topic><topic>Genetics</topic><topic>Glucose</topic><topic>Heart attacks</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Kinases</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Metabolism</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Smooth muscle</topic><topic>Software</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kemanci, Aykut</creatorcontrib><creatorcontrib>Goren, Tarik</creatorcontrib><creatorcontrib>Uluturk, Mehmet</creatorcontrib><creatorcontrib>Yilmaz, Atakan</creatorcontrib><creatorcontrib>Sabirli, Ramazan</creatorcontrib><creatorcontrib>Ozen, Mert</creatorcontrib><creatorcontrib>Seyit, Murat</creatorcontrib><creatorcontrib>Oskay, Alten</creatorcontrib><creatorcontrib>Koseler, Aylin</creatorcontrib><creatorcontrib>Turkcuer, Ibrahim</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kemanci, Aykut</au><au>Goren, Tarik</au><au>Uluturk, Mehmet</au><au>Yilmaz, Atakan</au><au>Sabirli, Ramazan</au><au>Ozen, Mert</au><au>Seyit, Murat</au><au>Oskay, Alten</au><au>Koseler, Aylin</au><au>Turkcuer, Ibrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2022-06-21</date><risdate>2022</risdate><volume>14</volume><issue>6</issue><spage>e26147</spage><epage>e26147</epage><pages>e26147-e26147</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Objective: This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically.Subject and methods: Peripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed.Results: PPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p<0.01).Conclusion: The findings revealed that elevated PPAR alpha L162V and PPAR gamma C161T gene polymorphisms were associated with a progressive risk of ACS.</abstract><cop>Palo Alto</cop><pub>Cureus Inc</pub><pmid>35891836</pmid><doi>10.7759/cureus.26147</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acute coronary syndromes Angina pectoris Apolipoproteins Atherosclerosis Blood pressure Cardiology Cardiovascular disease Cholesterol Coronary vessels Cytokines Emergency Medicine Genetics Glucose Heart attacks High density lipoprotein Hypertension Kinases Lipids Lipoproteins Metabolism Patients Polymorphism Smooth muscle Software Thrombosis |
| title | The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome |
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