A Rare Case of Metastatic Uveal Melanoma Responding to Immunotherapy
Uveal melanoma (UM) is an intraocular malignancy with poor survival rates due to the propensity for metastatic spread. Although treatment options exist for localized disease, there are fewer definitive guidelines for metastatic UM. Treatment involves a personalized approach that entails patient-spec...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-06, Vol.14 (6) |
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| creator | Fadel, Celine A Kanakamedala, Swathi Danak, Shivang U Johnson, Andrew T |
| description | Uveal melanoma (UM) is an intraocular malignancy with poor survival rates due to the propensity for metastatic spread. Although treatment options exist for localized disease, there are fewer definitive guidelines for metastatic UM. Treatment involves a personalized approach that entails patient-specific aspects, including tumor genetics. This case highlights the disease course of a 60-year-old male diagnosed with stage IIB right eye choroidal melanoma. Despite successful therapy for localized UM, he developed widespread metastasis. He received dual immunotherapy and was ultimately maintained on a single-agent regimen. His prognosis has surpassed initial prognosis and survival expectations. This case highlights the use of immunotherapy, both dual and single therapy, to treat this rare malignancy and extend overall survival. |
| doi_str_mv | 10.7759/cureus.26146 |
| format | Article |
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Although treatment options exist for localized disease, there are fewer definitive guidelines for metastatic UM. Treatment involves a personalized approach that entails patient-specific aspects, including tumor genetics. This case highlights the disease course of a 60-year-old male diagnosed with stage IIB right eye choroidal melanoma. Despite successful therapy for localized UM, he developed widespread metastasis. He received dual immunotherapy and was ultimately maintained on a single-agent regimen. His prognosis has surpassed initial prognosis and survival expectations. This case highlights the use of immunotherapy, both dual and single therapy, to treat this rare malignancy and extend overall survival.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.26146</identifier><identifier>PMID: 35891820</identifier><language>eng</language><publisher>Palo Alto: Cureus Inc</publisher><subject>Abdomen ; Angiogenesis ; Biopsy ; Case reports ; Chemotherapy ; Cytotoxicity ; Immunotherapy ; Internal Medicine ; Liver ; Magnetic resonance imaging ; Medical prognosis ; Melanoma ; Metastasis ; Mutation ; Oncology ; Ophthalmology ; Patients ; Radiation therapy ; Skin cancer ; Tomography ; Tumors ; Vascular endothelial growth factor ; White people</subject><ispartof>Curēus (Palo Alto, CA), 2022-06, Vol.14 (6)</ispartof><rights>Copyright © 2022, Fadel et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). 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Although treatment options exist for localized disease, there are fewer definitive guidelines for metastatic UM. Treatment involves a personalized approach that entails patient-specific aspects, including tumor genetics. This case highlights the disease course of a 60-year-old male diagnosed with stage IIB right eye choroidal melanoma. Despite successful therapy for localized UM, he developed widespread metastasis. He received dual immunotherapy and was ultimately maintained on a single-agent regimen. His prognosis has surpassed initial prognosis and survival expectations. This case highlights the use of immunotherapy, both dual and single therapy, to treat this rare malignancy and extend overall survival.</description><subject>Abdomen</subject><subject>Angiogenesis</subject><subject>Biopsy</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Cytotoxicity</subject><subject>Immunotherapy</subject><subject>Internal Medicine</subject><subject>Liver</subject><subject>Magnetic resonance imaging</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Skin cancer</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><subject>White people</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkE1LAzEQhoMottTe_AELXm3NZLdJ9iKU-gkVodhzmM1Hu6W7qcluof_e1RbR0wwzL88MDyHXQMdCTPI73QbbxjHjkPEz0mfA5UiCzM7_9D0yjHFDKQUqGBX0kvTSicxBMtonD9NkgcEmM4w28S55sw3GBptSJ8u9xW032GLtK0wWNu58bcp6lTQ-ea2qtvbN2gbcHa7IhcNttMNTHZDl0-PH7GU0f39-nU3nI80kb0ZMYmoYOARXiNRiZkyuraPCuAJYrl06cdxQCXleAIdCS45aUAMomclApgNyf-Tu2qKyRtu6CbhVu1BWGA7KY6n-b-pyrVZ-r_KUAhdZB7g5AYL_bG1s1Ma3oe5-VoznXEgOk7RL3R5TOvgYg3W_F4Cqb-3qqF39aE-_ABWddf8</recordid><startdate>20220621</startdate><enddate>20220621</enddate><creator>Fadel, Celine A</creator><creator>Kanakamedala, Swathi</creator><creator>Danak, Shivang U</creator><creator>Johnson, Andrew T</creator><general>Cureus Inc</general><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20220621</creationdate><title>A Rare Case of Metastatic Uveal Melanoma Responding to Immunotherapy</title><author>Fadel, Celine A ; Kanakamedala, Swathi ; Danak, Shivang U ; Johnson, Andrew T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-28a3d21fa1fb73ea4dd9cef07dfb129cf35f6d08199b161bc86ac70d1a82d4183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdomen</topic><topic>Angiogenesis</topic><topic>Biopsy</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Cytotoxicity</topic><topic>Immunotherapy</topic><topic>Internal Medicine</topic><topic>Liver</topic><topic>Magnetic resonance imaging</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Skin cancer</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fadel, Celine A</creatorcontrib><creatorcontrib>Kanakamedala, Swathi</creatorcontrib><creatorcontrib>Danak, Shivang U</creatorcontrib><creatorcontrib>Johnson, Andrew T</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fadel, Celine A</au><au>Kanakamedala, Swathi</au><au>Danak, Shivang U</au><au>Johnson, Andrew T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Rare Case of Metastatic Uveal Melanoma Responding to Immunotherapy</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2022-06-21</date><risdate>2022</risdate><volume>14</volume><issue>6</issue><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Uveal melanoma (UM) is an intraocular malignancy with poor survival rates due to the propensity for metastatic spread. 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| subjects | Abdomen Angiogenesis Biopsy Case reports Chemotherapy Cytotoxicity Immunotherapy Internal Medicine Liver Magnetic resonance imaging Medical prognosis Melanoma Metastasis Mutation Oncology Ophthalmology Patients Radiation therapy Skin cancer Tomography Tumors Vascular endothelial growth factor White people |
| title | A Rare Case of Metastatic Uveal Melanoma Responding to Immunotherapy |
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