Metal-free synthesis of C2-quaternary indolinones by (NH4)2S2O8 mediated oxidative dearomatization of indoles

An efficient metal-free, (NH4)2S2O8 mediated oxidative dearomatization of indoles for the construction of C2-quaternary indolinones was disclosed. A series of C2-quaternary indolinones derivatives with good functional group tolerance were obtained in moderate to excellent yields. This methodology pr...

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Veröffentlicht in:	RSC advances 2022-07, Vol.12 (33), p.21022-21025
Hauptverfasser:	Yu, Dong, Jun-Hu, Qian, Xiang-Long, Chen, Jiang, Hui, Li, Xue, Zhou, Qiang, Ting Mei, Zhi-Chuan Shi, Zhong-Hui, Li, He, Bing
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Sprache:	eng
Schlagworte:	Chemistry Functional groups Indoles
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container_issue	33
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container_title	RSC advances
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creator	Yu, Dong Jun-Hu, Qian Xiang-Long, Chen Jiang, Hui Li, Xue Zhou, Qiang Ting Mei Zhi-Chuan Shi Zhong-Hui, Li He, Bing
description	An efficient metal-free, (NH4)2S2O8 mediated oxidative dearomatization of indoles for the construction of C2-quaternary indolinones was disclosed. A series of C2-quaternary indolinones derivatives with good functional group tolerance were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C2 position of indoles. This catalytic approach represents a step-economic and convenient strategy for the oxidative dearomatization of indoles.
doi_str_mv	10.1039/d2ra04191j
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subjects	Chemistry Functional groups Indoles
title	Metal-free synthesis of C2-quaternary indolinones by (NH4)2S2O8 mediated oxidative dearomatization of indoles
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