Novel Autoantibodies in Idiopathic Small Fiber Neuropathy
Objective Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel hi...
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| Veröffentlicht in: | Annals of neurology 2022-01, Vol.91 (1), p.66-77 |
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| creator | Chan, Amanda C. Y. Wong, Hiu Yi Chong, Yao Feng Lai, Poh San Teoh, Hock Luen Ng, Alison Y. Y. Hung, Jennifer H. M. Chan, Yee Cheun Ng, Kay W. P. Vijayan, Joy Ong, Jonathan J. Y. Chandra, Bharatendu Tan, Chi Hsien Rutt, Nurul H. Tan, Ti Myen Ismail, Nur Hafiza Wilder‐Smith, Einar Schwarz, Herbert Choi, Hyungwon Sharma, Vijay K. Mak, Anselm |
| description | Objective
Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high‐throughput protein microarray platform that captures autoantibodies expressed in the native conformational state.
Methods
Sera from 58 SFN patients and 20 age‐ and gender‐matched healthy controls (HCs) were screened against >1,600 immune‐related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts.
Results
Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q |
| doi_str_mv | 10.1002/ana.26268 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9300200</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2596457033</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4438-79ad67d1e1aca33a90896033e911b8d17729724dea1907bf7081a7845043c4f63</originalsourceid><addsrcrecordid>eNp1kctKAzEUhoMoWi8LX0AG3Ohiak6SyWUjlOINSl2o65CZSTUyndRkptK3N1oVFVwFTj4-_nN-hA4BDwFjcmZaMySccLmBBlBQyCVhahMNMOUsL4CyHbQb4zPGWHHA22iHMsGBUTZAauqXtslGfedN27nS187GzLXZTe38wnRPrsru5qZpsktX2pBNbR8-5qt9tDUzTbQHn-8eeri8uB9f55Pbq5vxaJJXjFGZC2VqLmqwYCpDqVFYKo4ptQqglDUIQZQgrLYGFBblTGAJRkhWYEYrNuN0D52vvYu-nNu6sm0XTKMXwc1NWGlvnP7907on_eiXWtF0G4yT4ORTEPxLb2On5y5WtmlMa30fNSkUZ4VImRJ6_Ad99n1o03qacAApJZUkUadrqgo-xmBn32EA6_dCdCpEfxSS2KOf6b_JrwYScLYGXl1jV_-b9Gg6WivfALAokwo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2611888382</pqid></control><display><type>article</type><title>Novel Autoantibodies in Idiopathic Small Fiber Neuropathy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chan, Amanda C. Y. ; Wong, Hiu Yi ; Chong, Yao Feng ; Lai, Poh San ; Teoh, Hock Luen ; Ng, Alison Y. Y. ; Hung, Jennifer H. M. ; Chan, Yee Cheun ; Ng, Kay W. P. ; Vijayan, Joy ; Ong, Jonathan J. Y. ; Chandra, Bharatendu ; Tan, Chi Hsien ; Rutt, Nurul H. ; Tan, Ti Myen ; Ismail, Nur Hafiza ; Wilder‐Smith, Einar ; Schwarz, Herbert ; Choi, Hyungwon ; Sharma, Vijay K. ; Mak, Anselm</creator><creatorcontrib>Chan, Amanda C. Y. ; Wong, Hiu Yi ; Chong, Yao Feng ; Lai, Poh San ; Teoh, Hock Luen ; Ng, Alison Y. Y. ; Hung, Jennifer H. M. ; Chan, Yee Cheun ; Ng, Kay W. P. ; Vijayan, Joy ; Ong, Jonathan J. Y. ; Chandra, Bharatendu ; Tan, Chi Hsien ; Rutt, Nurul H. ; Tan, Ti Myen ; Ismail, Nur Hafiza ; Wilder‐Smith, Einar ; Schwarz, Herbert ; Choi, Hyungwon ; Sharma, Vijay K. ; Mak, Anselm</creatorcontrib><description>Objective
Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high‐throughput protein microarray platform that captures autoantibodies expressed in the native conformational state.
Methods
Sera from 58 SFN patients and 20 age‐ and gender‐matched healthy controls (HCs) were screened against >1,600 immune‐related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts.
Results
Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009).
Interpretation
Novel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66–77</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.26268</identifier><identifier>PMID: 34761434</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Antigens ; Autoantibodies ; Autoantibodies - blood ; Autoantibodies - immunology ; Autoantigens - immunology ; Autoimmunity ; Cohort Studies ; Etiology ; Female ; Fluorescence ; Humans ; Keratin-8 - immunology ; Male ; Microfilament Proteins - immunology ; Middle Aged ; Myxovirus Resistance Proteins - immunology ; Neuropathy ; Protein arrays ; Protein folding ; Proteins ; Serum levels ; Small Fiber Neuropathy - blood ; Small Fiber Neuropathy - immunology ; src Homology Domains - immunology ; Subgroups</subject><ispartof>Annals of neurology, 2022-01, Vol.91 (1), p.66-77</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of American Neurological Association.</rights><rights>2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-79ad67d1e1aca33a90896033e911b8d17729724dea1907bf7081a7845043c4f63</citedby><cites>FETCH-LOGICAL-c4438-79ad67d1e1aca33a90896033e911b8d17729724dea1907bf7081a7845043c4f63</cites><orcidid>0000-0003-3352-2000 ; 0000-0003-0735-8593 ; 0000-0002-2950-3707 ; 0000-0002-4688-7829</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.26268$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.26268$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34761434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Amanda C. Y.</creatorcontrib><creatorcontrib>Wong, Hiu Yi</creatorcontrib><creatorcontrib>Chong, Yao Feng</creatorcontrib><creatorcontrib>Lai, Poh San</creatorcontrib><creatorcontrib>Teoh, Hock Luen</creatorcontrib><creatorcontrib>Ng, Alison Y. Y.</creatorcontrib><creatorcontrib>Hung, Jennifer H. M.</creatorcontrib><creatorcontrib>Chan, Yee Cheun</creatorcontrib><creatorcontrib>Ng, Kay W. P.</creatorcontrib><creatorcontrib>Vijayan, Joy</creatorcontrib><creatorcontrib>Ong, Jonathan J. Y.</creatorcontrib><creatorcontrib>Chandra, Bharatendu</creatorcontrib><creatorcontrib>Tan, Chi Hsien</creatorcontrib><creatorcontrib>Rutt, Nurul H.</creatorcontrib><creatorcontrib>Tan, Ti Myen</creatorcontrib><creatorcontrib>Ismail, Nur Hafiza</creatorcontrib><creatorcontrib>Wilder‐Smith, Einar</creatorcontrib><creatorcontrib>Schwarz, Herbert</creatorcontrib><creatorcontrib>Choi, Hyungwon</creatorcontrib><creatorcontrib>Sharma, Vijay K.</creatorcontrib><creatorcontrib>Mak, Anselm</creatorcontrib><title>Novel Autoantibodies in Idiopathic Small Fiber Neuropathy</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective
Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high‐throughput protein microarray platform that captures autoantibodies expressed in the native conformational state.
Methods
Sera from 58 SFN patients and 20 age‐ and gender‐matched healthy controls (HCs) were screened against >1,600 immune‐related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts.
Results
Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009).
Interpretation
Novel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66–77</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - immunology</subject><subject>Autoantigens - immunology</subject><subject>Autoimmunity</subject><subject>Cohort Studies</subject><subject>Etiology</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Keratin-8 - immunology</subject><subject>Male</subject><subject>Microfilament Proteins - immunology</subject><subject>Middle Aged</subject><subject>Myxovirus Resistance Proteins - immunology</subject><subject>Neuropathy</subject><subject>Protein arrays</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Serum levels</subject><subject>Small Fiber Neuropathy - blood</subject><subject>Small Fiber Neuropathy - immunology</subject><subject>src Homology Domains - immunology</subject><subject>Subgroups</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctKAzEUhoMoWi8LX0AG3Ohiak6SyWUjlOINSl2o65CZSTUyndRkptK3N1oVFVwFTj4-_nN-hA4BDwFjcmZaMySccLmBBlBQyCVhahMNMOUsL4CyHbQb4zPGWHHA22iHMsGBUTZAauqXtslGfedN27nS187GzLXZTe38wnRPrsru5qZpsktX2pBNbR8-5qt9tDUzTbQHn-8eeri8uB9f55Pbq5vxaJJXjFGZC2VqLmqwYCpDqVFYKo4ptQqglDUIQZQgrLYGFBblTGAJRkhWYEYrNuN0D52vvYu-nNu6sm0XTKMXwc1NWGlvnP7907on_eiXWtF0G4yT4ORTEPxLb2On5y5WtmlMa30fNSkUZ4VImRJ6_Ad99n1o03qacAApJZUkUadrqgo-xmBn32EA6_dCdCpEfxSS2KOf6b_JrwYScLYGXl1jV_-b9Gg6WivfALAokwo</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Chan, Amanda C. Y.</creator><creator>Wong, Hiu Yi</creator><creator>Chong, Yao Feng</creator><creator>Lai, Poh San</creator><creator>Teoh, Hock Luen</creator><creator>Ng, Alison Y. Y.</creator><creator>Hung, Jennifer H. M.</creator><creator>Chan, Yee Cheun</creator><creator>Ng, Kay W. P.</creator><creator>Vijayan, Joy</creator><creator>Ong, Jonathan J. Y.</creator><creator>Chandra, Bharatendu</creator><creator>Tan, Chi Hsien</creator><creator>Rutt, Nurul H.</creator><creator>Tan, Ti Myen</creator><creator>Ismail, Nur Hafiza</creator><creator>Wilder‐Smith, Einar</creator><creator>Schwarz, Herbert</creator><creator>Choi, Hyungwon</creator><creator>Sharma, Vijay K.</creator><creator>Mak, Anselm</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3352-2000</orcidid><orcidid>https://orcid.org/0000-0003-0735-8593</orcidid><orcidid>https://orcid.org/0000-0002-2950-3707</orcidid><orcidid>https://orcid.org/0000-0002-4688-7829</orcidid></search><sort><creationdate>202201</creationdate><title>Novel Autoantibodies in Idiopathic Small Fiber Neuropathy</title><author>Chan, Amanda C. Y. ; Wong, Hiu Yi ; Chong, Yao Feng ; Lai, Poh San ; Teoh, Hock Luen ; Ng, Alison Y. Y. ; Hung, Jennifer H. M. ; Chan, Yee Cheun ; Ng, Kay W. P. ; Vijayan, Joy ; Ong, Jonathan J. Y. ; Chandra, Bharatendu ; Tan, Chi Hsien ; Rutt, Nurul H. ; Tan, Ti Myen ; Ismail, Nur Hafiza ; Wilder‐Smith, Einar ; Schwarz, Herbert ; Choi, Hyungwon ; Sharma, Vijay K. ; Mak, Anselm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-79ad67d1e1aca33a90896033e911b8d17729724dea1907bf7081a7845043c4f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Autoantibodies</topic><topic>Autoantibodies - blood</topic><topic>Autoantibodies - immunology</topic><topic>Autoantigens - immunology</topic><topic>Autoimmunity</topic><topic>Cohort Studies</topic><topic>Etiology</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>Keratin-8 - immunology</topic><topic>Male</topic><topic>Microfilament Proteins - immunology</topic><topic>Middle Aged</topic><topic>Myxovirus Resistance Proteins - immunology</topic><topic>Neuropathy</topic><topic>Protein arrays</topic><topic>Protein folding</topic><topic>Proteins</topic><topic>Serum levels</topic><topic>Small Fiber Neuropathy - blood</topic><topic>Small Fiber Neuropathy - immunology</topic><topic>src Homology Domains - immunology</topic><topic>Subgroups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Amanda C. Y.</creatorcontrib><creatorcontrib>Wong, Hiu Yi</creatorcontrib><creatorcontrib>Chong, Yao Feng</creatorcontrib><creatorcontrib>Lai, Poh San</creatorcontrib><creatorcontrib>Teoh, Hock Luen</creatorcontrib><creatorcontrib>Ng, Alison Y. Y.</creatorcontrib><creatorcontrib>Hung, Jennifer H. M.</creatorcontrib><creatorcontrib>Chan, Yee Cheun</creatorcontrib><creatorcontrib>Ng, Kay W. P.</creatorcontrib><creatorcontrib>Vijayan, Joy</creatorcontrib><creatorcontrib>Ong, Jonathan J. Y.</creatorcontrib><creatorcontrib>Chandra, Bharatendu</creatorcontrib><creatorcontrib>Tan, Chi Hsien</creatorcontrib><creatorcontrib>Rutt, Nurul H.</creatorcontrib><creatorcontrib>Tan, Ti Myen</creatorcontrib><creatorcontrib>Ismail, Nur Hafiza</creatorcontrib><creatorcontrib>Wilder‐Smith, Einar</creatorcontrib><creatorcontrib>Schwarz, Herbert</creatorcontrib><creatorcontrib>Choi, Hyungwon</creatorcontrib><creatorcontrib>Sharma, Vijay K.</creatorcontrib><creatorcontrib>Mak, Anselm</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Amanda C. Y.</au><au>Wong, Hiu Yi</au><au>Chong, Yao Feng</au><au>Lai, Poh San</au><au>Teoh, Hock Luen</au><au>Ng, Alison Y. Y.</au><au>Hung, Jennifer H. M.</au><au>Chan, Yee Cheun</au><au>Ng, Kay W. P.</au><au>Vijayan, Joy</au><au>Ong, Jonathan J. Y.</au><au>Chandra, Bharatendu</au><au>Tan, Chi Hsien</au><au>Rutt, Nurul H.</au><au>Tan, Ti Myen</au><au>Ismail, Nur Hafiza</au><au>Wilder‐Smith, Einar</au><au>Schwarz, Herbert</au><au>Choi, Hyungwon</au><au>Sharma, Vijay K.</au><au>Mak, Anselm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Autoantibodies in Idiopathic Small Fiber Neuropathy</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2022-01</date><risdate>2022</risdate><volume>91</volume><issue>1</issue><spage>66</spage><epage>77</epage><pages>66-77</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>Objective
Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high‐throughput protein microarray platform that captures autoantibodies expressed in the native conformational state.
Methods
Sera from 58 SFN patients and 20 age‐ and gender‐matched healthy controls (HCs) were screened against >1,600 immune‐related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts.
Results
Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009).
Interpretation
Novel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66–77</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>34761434</pmid><doi>10.1002/ana.26268</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3352-2000</orcidid><orcidid>https://orcid.org/0000-0003-0735-8593</orcidid><orcidid>https://orcid.org/0000-0002-2950-3707</orcidid><orcidid>https://orcid.org/0000-0002-4688-7829</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 2022-01, Vol.91 (1), p.66-77 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Antigens Autoantibodies Autoantibodies - blood Autoantibodies - immunology Autoantigens - immunology Autoimmunity Cohort Studies Etiology Female Fluorescence Humans Keratin-8 - immunology Male Microfilament Proteins - immunology Middle Aged Myxovirus Resistance Proteins - immunology Neuropathy Protein arrays Protein folding Proteins Serum levels Small Fiber Neuropathy - blood Small Fiber Neuropathy - immunology src Homology Domains - immunology Subgroups |
| title | Novel Autoantibodies in Idiopathic Small Fiber Neuropathy |
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