Haploinsufficient tumor suppressor PRP4K is negatively regulated during epithelial‐to‐mesenchymal transition

The pre‐mRNA processing factor 4 kinase (PRP4K, also known as PRPF4B) is an essential gene. However, reduced PRP4K expression is associated with aggressive breast and ovarian cancer phenotypes including taxane therapy resistance, increased cell migration and invasion in vitro, and cancer metastasis...

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Veröffentlicht in:	The FASEB journal 2021-11, Vol.35 (11), p.e22001-n/a
Hauptverfasser:	Clarke, Livia E., Cook, Allyson, Mathavarajah, Sabateeshan, Bera, Amit, Salsman, Jayme, Habib, Elias, Van Iderstine, Carter, Bydoun, Moamen, Lewis, Stephen M., Dellaire, Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	eIF3e epithelial‐to‐mesenchymal transition (EMT) haploinsufficient tumor suppression PRP4K PRPF4B TGF‐beta WNT5a YAP
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