Comparative survival of elderly renal transplant recipients with a living donor versus a deceased donor: A retrospective single center observational study
Summary Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. This study compares the survival outcome between living (LDK), regularly allocated (ETKAS), and Eurotransplant Senior Program (ESP) donor kidneys in elderly recipients. This is a single‐center retrospec...
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| Veröffentlicht in: | Transplant international 2021-12, Vol.34 (12), p.2746-2754 |
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| creator | Tegzess, Erzsi Gomes Neto, Antonio W. Pol, Robert A. Boer, Silke E. Peters‐Sengers, Hessel Sanders, Jan‐Stephan F. Berger, Stefan P. |
| description | Summary
Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. This study compares the survival outcome between living (LDK), regularly allocated (ETKAS), and Eurotransplant Senior Program (ESP) donor kidneys in elderly recipients. This is a single‐center retrospective cohort study of elderly kidney transplant recipients transplanted between 2005 and 2017. Primary outcome measures were nondeath‐censored graft, death‐censored graft, and patient survival. In total, 348 patients were transplanted, 109 recipients (31.3%) received an LDK, 100 (28.7%) an ETKAS, and 139 (40%) an ESP kidney. 62.5% were male, and median age was 68 years. LDK recipients had significantly better 5‐year nondeath‐censored graft survival compared with ETKAS and ESP (resp. 71.0% vs. 66.1% vs. 55.6%, P = 0.047). Death‐censored graft survival after 1 year was significantly better in LDK recipients (99.1%) (ETKAS 90.8%; ESP 87.7%, P |
| doi_str_mv | 10.1111/tri.14130 |
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Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. This study compares the survival outcome between living (LDK), regularly allocated (ETKAS), and Eurotransplant Senior Program (ESP) donor kidneys in elderly recipients. This is a single‐center retrospective cohort study of elderly kidney transplant recipients transplanted between 2005 and 2017. Primary outcome measures were nondeath‐censored graft, death‐censored graft, and patient survival. In total, 348 patients were transplanted, 109 recipients (31.3%) received an LDK, 100 (28.7%) an ETKAS, and 139 (40%) an ESP kidney. 62.5% were male, and median age was 68 years. LDK recipients had significantly better 5‐year nondeath‐censored graft survival compared with ETKAS and ESP (resp. 71.0% vs. 66.1% vs. 55.6%, P = 0.047). Death‐censored graft survival after 1 year was significantly better in LDK recipients (99.1%) (ETKAS 90.8%; ESP 87.7%, P < 0.001). After 5 years, the difference remained significant (P < 0.001) with little additional graft loss (97.7% vs. 88.1% vs. 85.6). There was no significant difference in patient survival after 5 years (71.7% vs. 67.4% vs 61.9%, P = 0.480). In elderly recipients, the patient survival benefits of an LDK are limited, but there is decreased death‐censored graft loss for LDK recipients. Nevertheless, graft survival in ETKAS and ESP remains satisfactory.
Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. In elderly recipients the patient survival benefits of a living donor kidney are limited, but there is decreased death‐censored graft loss for these recipients. Nevertheless, graft survival for recipients with a deceased donor remains satisfactory.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/tri.14130</identifier><identifier>PMID: 34626451</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Death ; deceased donor ; elderly patients ; Graft Survival ; Graft-versus-host reaction ; Grafting ; Humans ; Kidney ; Kidney Transplantation ; Kidney transplants ; Kidneys ; living donor ; Living Donors ; Male ; Mortality ; Observational studies ; Older people ; Original ; Original : Clinical Research ; patient survival ; Retrospective Studies ; Survival ; Tissue Donors ; Transplant Recipients ; Transplants & implants ; Treatment Outcome</subject><ispartof>Transplant international, 2021-12, Vol.34 (12), p.2746-2754</ispartof><rights>2021 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4430-540122a87b959ba3198ff060bc58865247f252432a9b42c1360f0ce4b667885b3</citedby><cites>FETCH-LOGICAL-c4430-540122a87b959ba3198ff060bc58865247f252432a9b42c1360f0ce4b667885b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftri.14130$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftri.14130$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34626451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tegzess, Erzsi</creatorcontrib><creatorcontrib>Gomes Neto, Antonio W.</creatorcontrib><creatorcontrib>Pol, Robert A.</creatorcontrib><creatorcontrib>Boer, Silke E.</creatorcontrib><creatorcontrib>Peters‐Sengers, Hessel</creatorcontrib><creatorcontrib>Sanders, Jan‐Stephan F.</creatorcontrib><creatorcontrib>Berger, Stefan P.</creatorcontrib><title>Comparative survival of elderly renal transplant recipients with a living donor versus a deceased donor: A retrospective single center observational study</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. This study compares the survival outcome between living (LDK), regularly allocated (ETKAS), and Eurotransplant Senior Program (ESP) donor kidneys in elderly recipients. This is a single‐center retrospective cohort study of elderly kidney transplant recipients transplanted between 2005 and 2017. Primary outcome measures were nondeath‐censored graft, death‐censored graft, and patient survival. In total, 348 patients were transplanted, 109 recipients (31.3%) received an LDK, 100 (28.7%) an ETKAS, and 139 (40%) an ESP kidney. 62.5% were male, and median age was 68 years. LDK recipients had significantly better 5‐year nondeath‐censored graft survival compared with ETKAS and ESP (resp. 71.0% vs. 66.1% vs. 55.6%, P = 0.047). Death‐censored graft survival after 1 year was significantly better in LDK recipients (99.1%) (ETKAS 90.8%; ESP 87.7%, P < 0.001). After 5 years, the difference remained significant (P < 0.001) with little additional graft loss (97.7% vs. 88.1% vs. 85.6). There was no significant difference in patient survival after 5 years (71.7% vs. 67.4% vs 61.9%, P = 0.480). In elderly recipients, the patient survival benefits of an LDK are limited, but there is decreased death‐censored graft loss for LDK recipients. Nevertheless, graft survival in ETKAS and ESP remains satisfactory.
Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. In elderly recipients the patient survival benefits of a living donor kidney are limited, but there is decreased death‐censored graft loss for these recipients. Nevertheless, graft survival for recipients with a deceased donor remains satisfactory.</description><subject>Aged</subject><subject>Death</subject><subject>deceased donor</subject><subject>elderly patients</subject><subject>Graft Survival</subject><subject>Graft-versus-host reaction</subject><subject>Grafting</subject><subject>Humans</subject><subject>Kidney</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>living donor</subject><subject>Living Donors</subject><subject>Male</subject><subject>Mortality</subject><subject>Observational studies</subject><subject>Older people</subject><subject>Original</subject><subject>Original : Clinical Research</subject><subject>patient survival</subject><subject>Retrospective Studies</subject><subject>Survival</subject><subject>Tissue Donors</subject><subject>Transplant Recipients</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc9qFTEUxoMo9lpd-AIScGMX0-bvTOJCKJeqhYIgdR0ymTNtSu5kTGam3Ffxac11alHBLBL48st3vpyD0GtKTmlZZ1Pyp1RQTp6gDRWcVYw1zVO0IZqLiqhGHKEXOd8RQpiS5Dk64qJmtZB0g35s4260yU5-AZzntPjFBhx7DKGDFPY4wVCEKdkhj8EOUxGcHz0MU8b3frrFFge_-OEGd3GICS-Q8pyL2oEDm6Fb9ff4vLycUswjuLVYeRMAu-IECcc2Q1pKjHgol6e5279Ez3obMrx6OI_Rt48X19vP1dWXT5fb86vKCcFJJQWhjFnVtFrq1nKqVd-TmrROKlVLJpqelZ0zq1vBHOU16YkD0dZ1o5Rs-TH6sPqOc7uD7hAo2WDG5Hc27U203vx9M_hbcxMXo5luNOfF4N2DQYrfZ8iT2fnsIJR2QZyzYVKRWnOtWEHf_oPexTmVLxeqppJpKuWBOlkpV_qVE_SPYSgxh4mbMnHza-KFffNn-kfy94gLcLYC9z7A_v9O5vrr5Wr5EyFGuKg</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Tegzess, Erzsi</creator><creator>Gomes Neto, Antonio W.</creator><creator>Pol, Robert A.</creator><creator>Boer, Silke E.</creator><creator>Peters‐Sengers, Hessel</creator><creator>Sanders, Jan‐Stephan F.</creator><creator>Berger, Stefan P.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202112</creationdate><title>Comparative survival of elderly renal transplant recipients with a living donor versus a deceased donor: A retrospective single center observational study</title><author>Tegzess, Erzsi ; Gomes Neto, Antonio W. ; Pol, Robert A. ; Boer, Silke E. ; Peters‐Sengers, Hessel ; Sanders, Jan‐Stephan F. ; Berger, Stefan P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4430-540122a87b959ba3198ff060bc58865247f252432a9b42c1360f0ce4b667885b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Death</topic><topic>deceased donor</topic><topic>elderly patients</topic><topic>Graft Survival</topic><topic>Graft-versus-host reaction</topic><topic>Grafting</topic><topic>Humans</topic><topic>Kidney</topic><topic>Kidney Transplantation</topic><topic>Kidney transplants</topic><topic>Kidneys</topic><topic>living donor</topic><topic>Living Donors</topic><topic>Male</topic><topic>Mortality</topic><topic>Observational studies</topic><topic>Older people</topic><topic>Original</topic><topic>Original : Clinical Research</topic><topic>patient survival</topic><topic>Retrospective Studies</topic><topic>Survival</topic><topic>Tissue Donors</topic><topic>Transplant Recipients</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tegzess, Erzsi</creatorcontrib><creatorcontrib>Gomes Neto, Antonio W.</creatorcontrib><creatorcontrib>Pol, Robert A.</creatorcontrib><creatorcontrib>Boer, Silke E.</creatorcontrib><creatorcontrib>Peters‐Sengers, Hessel</creatorcontrib><creatorcontrib>Sanders, Jan‐Stephan F.</creatorcontrib><creatorcontrib>Berger, Stefan P.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tegzess, Erzsi</au><au>Gomes Neto, Antonio W.</au><au>Pol, Robert A.</au><au>Boer, Silke E.</au><au>Peters‐Sengers, Hessel</au><au>Sanders, Jan‐Stephan F.</au><au>Berger, Stefan P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative survival of elderly renal transplant recipients with a living donor versus a deceased donor: A retrospective single center observational study</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2021-12</date><risdate>2021</risdate><volume>34</volume><issue>12</issue><spage>2746</spage><epage>2754</epage><pages>2746-2754</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. This study compares the survival outcome between living (LDK), regularly allocated (ETKAS), and Eurotransplant Senior Program (ESP) donor kidneys in elderly recipients. This is a single‐center retrospective cohort study of elderly kidney transplant recipients transplanted between 2005 and 2017. Primary outcome measures were nondeath‐censored graft, death‐censored graft, and patient survival. In total, 348 patients were transplanted, 109 recipients (31.3%) received an LDK, 100 (28.7%) an ETKAS, and 139 (40%) an ESP kidney. 62.5% were male, and median age was 68 years. LDK recipients had significantly better 5‐year nondeath‐censored graft survival compared with ETKAS and ESP (resp. 71.0% vs. 66.1% vs. 55.6%, P = 0.047). Death‐censored graft survival after 1 year was significantly better in LDK recipients (99.1%) (ETKAS 90.8%; ESP 87.7%, P < 0.001). After 5 years, the difference remained significant (P < 0.001) with little additional graft loss (97.7% vs. 88.1% vs. 85.6). There was no significant difference in patient survival after 5 years (71.7% vs. 67.4% vs 61.9%, P = 0.480). In elderly recipients, the patient survival benefits of an LDK are limited, but there is decreased death‐censored graft loss for LDK recipients. Nevertheless, graft survival in ETKAS and ESP remains satisfactory.
Increasing numbers of elderly (≥65 years) patients are listed for kidney transplantation. In elderly recipients the patient survival benefits of a living donor kidney are limited, but there is decreased death‐censored graft loss for these recipients. Nevertheless, graft survival for recipients with a deceased donor remains satisfactory.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>34626451</pmid><doi>10.1111/tri.14130</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Death deceased donor elderly patients Graft Survival Graft-versus-host reaction Grafting Humans Kidney Kidney Transplantation Kidney transplants Kidneys living donor Living Donors Male Mortality Observational studies Older people Original Original : Clinical Research patient survival Retrospective Studies Survival Tissue Donors Transplant Recipients Transplants & implants Treatment Outcome |
| title | Comparative survival of elderly renal transplant recipients with a living donor versus a deceased donor: A retrospective single center observational study |
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