Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma

Abstract Composite pleomorphic xanthoastrocytoma-ganglioglioma (PXA-GG) is an extremely rare central nervous system neoplasm with 2 distinct but intermingled components. Whether this tumor represents a “collision tumor” of separate neoplasms or a monoclonal neoplasm with divergent evolution is poorl...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2022-08, Vol.81 (8), p.650-657
Hauptverfasser:	Lucas, Calixto-Hope G, Davidson, Christian J, Alashari, Mouied, Putnam, Angelica R, Whipple, Nicholas S, Bruggers, Carol S, Mendez, Joe S, Cheshier, Samuel H, Walker, Jeffrey B, Ramani, Biswarathan, Cadwell, Cathryn R, Sullivan, Daniel V, Lu, Rufei, Mirchia, Kanish, Van Ziffle, Jessica, Devine, Patrick, Goldschmidt, Ezequiel, Hervey-Jumper, Shawn L, Gupta, Nalin, Oberheim Bush, Nancy Ann, Raleigh, David R, Bollen, Andrew, Tihan, Tarik, Pekmezci, Melike, Solomon, David A, Phillips, Joanna J, Perry, Arie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Astrocytoma Astrocytoma - genetics Astrocytoma - pathology Brain Neoplasms - genetics Brain Neoplasms - pathology Care and treatment Clonal Evolution Cyclin-Dependent Kinase Inhibitor p16 - genetics Diagnosis DNA DNA sequencing Female Ganglioglioma - pathology Genetic aspects Health aspects High-Throughput Nucleotide Sequencing Homozygote Humans Male Morphological variation Mutation - genetics Nucleotide sequencing Original Proto-Oncogene Proteins B-raf - genetics Sequence Deletion Tumors Young Adult
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