The AraC/XylS Protein MxiE and Its Coregulator IpgC Control a Negative Feedback Loop in the Transcriptional Cascade That Regulates Type III Secretion in Shigella flexneri

Members of the AraC family of transcriptional regulators (AFTRs) control the expression of many genes important to cellular processes, including virulence. In species, the type III secretion system (T3SS), a key determinant for host cell invasion, is regulated by the three-tiered VirF/VirB/MxiE tran...

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Veröffentlicht in:	Journal of bacteriology 2022-07, Vol.204 (7), p.e0013722
Hauptverfasser:	McKenna, Joy A, Karney, Monika M A, Chan, Daniel K, Weatherspoon-Griffin, Natasha, Becerra Larios, Brianda, Pilonieta, M Carolina, Munson, George P, Wing, Helen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - metabolism Bacteriology Control theory Cytarabine - metabolism DNA-Binding Proteins - metabolism Feedback Feedback loops Gene expression Gene Expression Regulation, Bacterial Genes Genetics and Molecular Biology Homology Negative feedback Proteins Research Article Secretion Shigella Shigella flexneri - genetics Shigella flexneri - metabolism Transcription Transcription, Genetic Type III Secretion Systems - genetics Type III Secretion Systems - metabolism VirB protein Virulence Virulence Factors - genetics Virulence Factors - metabolism
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