Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

B-cell activating factor (BAFF) is involved in not only physiology of normal B cells, but also pathophysiology of aggressive B cells related to malignant and autoimmune diseases. Rapamycin, a lipophilic macrolide antibiotic, has recently shown to be effective in the treatment of human lupus erythema...

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Veröffentlicht in:Cellular and molecular life sciences : CMLS 2015-12, Vol.72 (24), p.4867-4884
Hauptverfasser: Zeng, Qingyu, Zhang, Hai, Qin, Jiamin, Xu, Zhigang, Gui, Lin, Liu, Beibei, Liu, Chunxiao, Xu, Chong, Liu, Wen, Zhang, Shuangquan, Huang, Shile, Chen, Long
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Sprache:eng
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