Restriction of SARS-CoV-2 replication in the human placenta

Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms. •The mechanisms of the placental barrier against SARS-CoV-2 are still unknown.•Replication of SARS-CoV-2 may be restricted in the placenta.•The first compelling evidence of inefficient viral replication in the placenta.