Potential increase in radiation‐induced DNA double‐strand breaks with higher doses of iodine contrast during coronary CT angiography
Purpose To investigate the contrast media iodine dose dependency of radiation‐induced DNA double‐strand breaks (DSBs) during a coronary computed tomography angiography (CCTA) scan. Methods This prospective patient study was approved by the ethical committee. Between November 2018 and July 2019, 50 p...
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| Veröffentlicht in: | Medical physics (Lancaster) 2021-11, Vol.48 (11), p.7526-7533 |
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| creator | Van Cauteren, Toon Tanaka, Kaoru Belsack, Dries Van Gompel, Gert Kersemans, Veerle Jochmans, Kristin Droogmans, Steven Mey, Johan Buls, Nico |
| description | Purpose
To investigate the contrast media iodine dose dependency of radiation‐induced DNA double‐strand breaks (DSBs) during a coronary computed tomography angiography (CCTA) scan.
Methods
This prospective patient study was approved by the ethical committee. Between November 2018 and July 2019, 50 patients (31 males and 19 females, mean age 64 years) were included in the study, 45 CCTA and five noncontrast‐enhanced (NCE) cardiac computed tomography (CT) patients. A single‐heartbeat scan protocol with a patient‐tailored contrast media injection protocol was used, administering a patient‐specific iodine dose. DNA double‐strand breaks were quantified using a γH2AX foci assay on peripheral blood lymphocytes. The net amount of γH2AX/cell was normalized to the individual patient CT dose by the size‐specific dose estimate (SSDE). Correlation between the administered and blood‐iodine dose and the SSDE normalized amount of DNA DSBs was investigated using a Pearson correlation test.
Results
CCTA patients were scanned with a mean CTDIvol of 10.6 ± 5.6 mGy, corresponding to a mean SSDE of 11.3 ± 5.3 mGy while the NCE cardiac CT patients were scanned with a mean CTDIvol of 6.00 ± 1.8 mGy, corresponding to a mean SSDE of 6.6 ± 2.7 mGy. The administered iodine dose ranged from 16.5 to 34.0 gI in the CCTA patients, resulting in a blood‐iodine dose range from 5.1 to 15.0 gI in the exposed blood volume. A significant linear relationship (r = 0.79, p‐value |
| doi_str_mv | 10.1002/mp.15253 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9293077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2576915962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4103-62cb6b1665b61060408ab68e650def91c88a6869dd74fa906a2a397060de300c3</originalsourceid><addsrcrecordid>eNp1kT1v1TAUhi1ERS8FiV-APLKknDiJEy9I1S1fUls6lNly7JPEkNjBTqjuxsjIb-SX4HJLKQOTvx4_55VeQp7lcJwDsJfTfJxXrCoekA0r6yIrGYiHZAMgyoyVUB2SxzF-AgBeVPCIHBZlxcuGsw35fukXdItVI7VOB1QR04YGZaxarHc_v_2wzqwaDT29OKHGr-2I6TIuQTlD2_Tjc6TXdhnoYPsBQ0IiRuo7ar2xDqn2LrFxoWYN1vXpHLxTYUe3V1S53vo-qHnYPSEHnRojPr1dj8jHN6-vtu-ysw9v329PzjJd5lBknOmWtznnVctz4FBCo1reIK_AYCdy3TSKN1wYU5edEsAVU4WoE2mwANDFEXm1985rO6HReJNulHOwUwolvbLy3xdnB9n7r1IwUUBdJ8GLW0HwX1aMi5xs1DiOyqFfo2RVzUVeCc7-ojr4GAN2d2NykDfFyWmWv4tL6PP7se7AP00lINsD13bE3X9F8vxyL_wFAGCmMQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2576915962</pqid></control><display><type>article</type><title>Potential increase in radiation‐induced DNA double‐strand breaks with higher doses of iodine contrast during coronary CT angiography</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Van Cauteren, Toon ; Tanaka, Kaoru ; Belsack, Dries ; Van Gompel, Gert ; Kersemans, Veerle ; Jochmans, Kristin ; Droogmans, Steven ; Mey, Johan ; Buls, Nico</creator><creatorcontrib>Van Cauteren, Toon ; Tanaka, Kaoru ; Belsack, Dries ; Van Gompel, Gert ; Kersemans, Veerle ; Jochmans, Kristin ; Droogmans, Steven ; Mey, Johan ; Buls, Nico</creatorcontrib><description>Purpose
To investigate the contrast media iodine dose dependency of radiation‐induced DNA double‐strand breaks (DSBs) during a coronary computed tomography angiography (CCTA) scan.
Methods
This prospective patient study was approved by the ethical committee. Between November 2018 and July 2019, 50 patients (31 males and 19 females, mean age 64 years) were included in the study, 45 CCTA and five noncontrast‐enhanced (NCE) cardiac computed tomography (CT) patients. A single‐heartbeat scan protocol with a patient‐tailored contrast media injection protocol was used, administering a patient‐specific iodine dose. DNA double‐strand breaks were quantified using a γH2AX foci assay on peripheral blood lymphocytes. The net amount of γH2AX/cell was normalized to the individual patient CT dose by the size‐specific dose estimate (SSDE). Correlation between the administered and blood‐iodine dose and the SSDE normalized amount of DNA DSBs was investigated using a Pearson correlation test.
Results
CCTA patients were scanned with a mean CTDIvol of 10.6 ± 5.6 mGy, corresponding to a mean SSDE of 11.3 ± 5.3 mGy while the NCE cardiac CT patients were scanned with a mean CTDIvol of 6.00 ± 1.8 mGy, corresponding to a mean SSDE of 6.6 ± 2.7 mGy. The administered iodine dose ranged from 16.5 to 34.0 gI in the CCTA patients, resulting in a blood‐iodine dose range from 5.1 to 15.0 gI in the exposed blood volume. A significant linear relationship (r = 0.79, p‐value < 0.001) was observed between the blood iodine dose and SSDE normalized radiation‐induced DNA DSBs. A similar significant linear relationship (r = 0.62, p‐value < 0.001) was observed between the administered iodine dose and SSDE normalized radiation‐induced DNA DSBs.
Conclusions
This study shows that contrast media iodine dose increases the level of radiation‐induced DNA DSBs in peripheral blood lymphocytes in a linear dose‐dependent manner with CCTA. Importantly, the level of DNA DSBs can be reduced by lowering the administered iodine dose.</description><identifier>ISSN: 0094-2405</identifier><identifier>ISSN: 2473-4209</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1002/mp.15253</identifier><identifier>PMID: 34564862</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>BIOLOGICAL PHYSICS AND RESPONSE PREDICTION ; Computed Tomography Angiography ; Contrast Media ; Coronary Angiography ; DNA ; DNA Breaks, Double-Stranded ; DNA double‐strand breaks ; Female ; Humans ; Iodine ; Male ; Middle Aged ; patient safety ; Prospective Studies ; Radiation Dosage</subject><ispartof>Medical physics (Lancaster), 2021-11, Vol.48 (11), p.7526-7533</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine</rights><rights>2021 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4103-62cb6b1665b61060408ab68e650def91c88a6869dd74fa906a2a397060de300c3</citedby><cites>FETCH-LOGICAL-c4103-62cb6b1665b61060408ab68e650def91c88a6869dd74fa906a2a397060de300c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmp.15253$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmp.15253$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34564862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Cauteren, Toon</creatorcontrib><creatorcontrib>Tanaka, Kaoru</creatorcontrib><creatorcontrib>Belsack, Dries</creatorcontrib><creatorcontrib>Van Gompel, Gert</creatorcontrib><creatorcontrib>Kersemans, Veerle</creatorcontrib><creatorcontrib>Jochmans, Kristin</creatorcontrib><creatorcontrib>Droogmans, Steven</creatorcontrib><creatorcontrib>Mey, Johan</creatorcontrib><creatorcontrib>Buls, Nico</creatorcontrib><title>Potential increase in radiation‐induced DNA double‐strand breaks with higher doses of iodine contrast during coronary CT angiography</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose
To investigate the contrast media iodine dose dependency of radiation‐induced DNA double‐strand breaks (DSBs) during a coronary computed tomography angiography (CCTA) scan.
Methods
This prospective patient study was approved by the ethical committee. Between November 2018 and July 2019, 50 patients (31 males and 19 females, mean age 64 years) were included in the study, 45 CCTA and five noncontrast‐enhanced (NCE) cardiac computed tomography (CT) patients. A single‐heartbeat scan protocol with a patient‐tailored contrast media injection protocol was used, administering a patient‐specific iodine dose. DNA double‐strand breaks were quantified using a γH2AX foci assay on peripheral blood lymphocytes. The net amount of γH2AX/cell was normalized to the individual patient CT dose by the size‐specific dose estimate (SSDE). Correlation between the administered and blood‐iodine dose and the SSDE normalized amount of DNA DSBs was investigated using a Pearson correlation test.
Results
CCTA patients were scanned with a mean CTDIvol of 10.6 ± 5.6 mGy, corresponding to a mean SSDE of 11.3 ± 5.3 mGy while the NCE cardiac CT patients were scanned with a mean CTDIvol of 6.00 ± 1.8 mGy, corresponding to a mean SSDE of 6.6 ± 2.7 mGy. The administered iodine dose ranged from 16.5 to 34.0 gI in the CCTA patients, resulting in a blood‐iodine dose range from 5.1 to 15.0 gI in the exposed blood volume. A significant linear relationship (r = 0.79, p‐value < 0.001) was observed between the blood iodine dose and SSDE normalized radiation‐induced DNA DSBs. A similar significant linear relationship (r = 0.62, p‐value < 0.001) was observed between the administered iodine dose and SSDE normalized radiation‐induced DNA DSBs.
Conclusions
This study shows that contrast media iodine dose increases the level of radiation‐induced DNA DSBs in peripheral blood lymphocytes in a linear dose‐dependent manner with CCTA. Importantly, the level of DNA DSBs can be reduced by lowering the administered iodine dose.</description><subject>BIOLOGICAL PHYSICS AND RESPONSE PREDICTION</subject><subject>Computed Tomography Angiography</subject><subject>Contrast Media</subject><subject>Coronary Angiography</subject><subject>DNA</subject><subject>DNA Breaks, Double-Stranded</subject><subject>DNA double‐strand breaks</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>patient safety</subject><subject>Prospective Studies</subject><subject>Radiation Dosage</subject><issn>0094-2405</issn><issn>2473-4209</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kT1v1TAUhi1ERS8FiV-APLKknDiJEy9I1S1fUls6lNly7JPEkNjBTqjuxsjIb-SX4HJLKQOTvx4_55VeQp7lcJwDsJfTfJxXrCoekA0r6yIrGYiHZAMgyoyVUB2SxzF-AgBeVPCIHBZlxcuGsw35fukXdItVI7VOB1QR04YGZaxarHc_v_2wzqwaDT29OKHGr-2I6TIuQTlD2_Tjc6TXdhnoYPsBQ0IiRuo7ar2xDqn2LrFxoWYN1vXpHLxTYUe3V1S53vo-qHnYPSEHnRojPr1dj8jHN6-vtu-ysw9v329PzjJd5lBknOmWtznnVctz4FBCo1reIK_AYCdy3TSKN1wYU5edEsAVU4WoE2mwANDFEXm1985rO6HReJNulHOwUwolvbLy3xdnB9n7r1IwUUBdJ8GLW0HwX1aMi5xs1DiOyqFfo2RVzUVeCc7-ojr4GAN2d2NykDfFyWmWv4tL6PP7se7AP00lINsD13bE3X9F8vxyL_wFAGCmMQ</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Van Cauteren, Toon</creator><creator>Tanaka, Kaoru</creator><creator>Belsack, Dries</creator><creator>Van Gompel, Gert</creator><creator>Kersemans, Veerle</creator><creator>Jochmans, Kristin</creator><creator>Droogmans, Steven</creator><creator>Mey, Johan</creator><creator>Buls, Nico</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202111</creationdate><title>Potential increase in radiation‐induced DNA double‐strand breaks with higher doses of iodine contrast during coronary CT angiography</title><author>Van Cauteren, Toon ; Tanaka, Kaoru ; Belsack, Dries ; Van Gompel, Gert ; Kersemans, Veerle ; Jochmans, Kristin ; Droogmans, Steven ; Mey, Johan ; Buls, Nico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4103-62cb6b1665b61060408ab68e650def91c88a6869dd74fa906a2a397060de300c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>BIOLOGICAL PHYSICS AND RESPONSE PREDICTION</topic><topic>Computed Tomography Angiography</topic><topic>Contrast Media</topic><topic>Coronary Angiography</topic><topic>DNA</topic><topic>DNA Breaks, Double-Stranded</topic><topic>DNA double‐strand breaks</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>patient safety</topic><topic>Prospective Studies</topic><topic>Radiation Dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Cauteren, Toon</creatorcontrib><creatorcontrib>Tanaka, Kaoru</creatorcontrib><creatorcontrib>Belsack, Dries</creatorcontrib><creatorcontrib>Van Gompel, Gert</creatorcontrib><creatorcontrib>Kersemans, Veerle</creatorcontrib><creatorcontrib>Jochmans, Kristin</creatorcontrib><creatorcontrib>Droogmans, Steven</creatorcontrib><creatorcontrib>Mey, Johan</creatorcontrib><creatorcontrib>Buls, Nico</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Cauteren, Toon</au><au>Tanaka, Kaoru</au><au>Belsack, Dries</au><au>Van Gompel, Gert</au><au>Kersemans, Veerle</au><au>Jochmans, Kristin</au><au>Droogmans, Steven</au><au>Mey, Johan</au><au>Buls, Nico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential increase in radiation‐induced DNA double‐strand breaks with higher doses of iodine contrast during coronary CT angiography</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2021-11</date><risdate>2021</risdate><volume>48</volume><issue>11</issue><spage>7526</spage><epage>7533</epage><pages>7526-7533</pages><issn>0094-2405</issn><issn>2473-4209</issn><eissn>2473-4209</eissn><abstract>Purpose
To investigate the contrast media iodine dose dependency of radiation‐induced DNA double‐strand breaks (DSBs) during a coronary computed tomography angiography (CCTA) scan.
Methods
This prospective patient study was approved by the ethical committee. Between November 2018 and July 2019, 50 patients (31 males and 19 females, mean age 64 years) were included in the study, 45 CCTA and five noncontrast‐enhanced (NCE) cardiac computed tomography (CT) patients. A single‐heartbeat scan protocol with a patient‐tailored contrast media injection protocol was used, administering a patient‐specific iodine dose. DNA double‐strand breaks were quantified using a γH2AX foci assay on peripheral blood lymphocytes. The net amount of γH2AX/cell was normalized to the individual patient CT dose by the size‐specific dose estimate (SSDE). Correlation between the administered and blood‐iodine dose and the SSDE normalized amount of DNA DSBs was investigated using a Pearson correlation test.
Results
CCTA patients were scanned with a mean CTDIvol of 10.6 ± 5.6 mGy, corresponding to a mean SSDE of 11.3 ± 5.3 mGy while the NCE cardiac CT patients were scanned with a mean CTDIvol of 6.00 ± 1.8 mGy, corresponding to a mean SSDE of 6.6 ± 2.7 mGy. The administered iodine dose ranged from 16.5 to 34.0 gI in the CCTA patients, resulting in a blood‐iodine dose range from 5.1 to 15.0 gI in the exposed blood volume. A significant linear relationship (r = 0.79, p‐value < 0.001) was observed between the blood iodine dose and SSDE normalized radiation‐induced DNA DSBs. A similar significant linear relationship (r = 0.62, p‐value < 0.001) was observed between the administered iodine dose and SSDE normalized radiation‐induced DNA DSBs.
Conclusions
This study shows that contrast media iodine dose increases the level of radiation‐induced DNA DSBs in peripheral blood lymphocytes in a linear dose‐dependent manner with CCTA. Importantly, the level of DNA DSBs can be reduced by lowering the administered iodine dose.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>34564862</pmid><doi>10.1002/mp.15253</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | BIOLOGICAL PHYSICS AND RESPONSE PREDICTION Computed Tomography Angiography Contrast Media Coronary Angiography DNA DNA Breaks, Double-Stranded DNA double‐strand breaks Female Humans Iodine Male Middle Aged patient safety Prospective Studies Radiation Dosage |
| title | Potential increase in radiation‐induced DNA double‐strand breaks with higher doses of iodine contrast during coronary CT angiography |
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