Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats
ABSTRACT Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats. Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% sil...
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| Veröffentlicht in: | Acta Cirúrgica Brasileira 2022-01, Vol.37 (4) |
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| creator | Bernardes, Milton Junior Cândido Gonçalves, Randys Caldeira Carvalho, Carolyna de Sousa Rosa, Luciana Martins Ferreira, Amanda Peixoto Vilela, Marielle Sousa Vinaud, Marina Clare Galdino Junior, Hélio Lino Junior, Ruy de Souza |
| description | ABSTRACT Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats. Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed. Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p |
| doi_str_mv | 10.1590/acb370401 |
| format | Article |
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Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed. Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05). Conclusions: The hydrogel-based dressings presented beneficial outcomes in the healing of burn wounds experimentally induced in rats due to their ability in maintain the humidity of the wound, in removing the exudate, in promoting cell migration and collagen production during the different phases of the healing process.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>DOI: 10.1590/acb370401</identifier><identifier>PMID: 35792743</identifier><language>eng</language><publisher>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</publisher><subject>Burns ; Hydrogels ; Original ; Rats ; Wound Healing</subject><ispartof>Acta Cirúrgica Brasileira, 2022-01, Vol.37 (4)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-798fba1649872058e048c0c8f636d613bf667dfc0dd474fdd047c657ab77f20b3</citedby><cites>FETCH-LOGICAL-c457t-798fba1649872058e048c0c8f636d613bf667dfc0dd474fdd047c657ab77f20b3</cites><orcidid>0000-0003-4029-7518 ; 0000-0002-3778-0819 ; 0000-0003-2780-1185 ; 0000-0002-6746-9191 ; 0000-0003-4847-4056 ; 0000-0002-0572-5102 ; 0000-0001-7346-0786 ; 0000-0003-3675-9628 ; 0000-0002-5570-8183</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27925,27926,53792,53794</link.rule.ids></links><search><creatorcontrib>Bernardes, Milton Junior Cândido</creatorcontrib><creatorcontrib>Gonçalves, Randys Caldeira</creatorcontrib><creatorcontrib>Carvalho, Carolyna de Sousa</creatorcontrib><creatorcontrib>Rosa, Luciana Martins</creatorcontrib><creatorcontrib>Ferreira, Amanda Peixoto</creatorcontrib><creatorcontrib>Vilela, Marielle Sousa</creatorcontrib><creatorcontrib>Vinaud, Marina Clare</creatorcontrib><creatorcontrib>Galdino Junior, Hélio</creatorcontrib><creatorcontrib>Lino Junior, Ruy de Souza</creatorcontrib><title>Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats</title><title>Acta Cirúrgica Brasileira</title><description>ABSTRACT Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats. Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed. Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05). Conclusions: The hydrogel-based dressings presented beneficial outcomes in the healing of burn wounds experimentally induced in rats due to their ability in maintain the humidity of the wound, in removing the exudate, in promoting cell migration and collagen production during the different phases of the healing process.</description><subject>Burns</subject><subject>Hydrogels</subject><subject>Original</subject><subject>Rats</subject><subject>Wound Healing</subject><issn>0102-8650</issn><issn>1678-2674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU9rGzEQxUVpqZ20h36DveawzWil1WgvhRKa2hDIJTmL0T9n0_WukdZp_e0rx8GQ08C8eT_e8Bj7xuE7bzu4JmcFggT-gS25Ql03CuVHtgQOTa1VCwt2kfMzAJeKi89sIVrsGpRiyfrVwadpE4baUg6-8ink3I-bXPVjNT-Fak6B5m0Y52qK1Y7S3NNQhN79GctlFf7tQuqPOg3DoZj83hWM3aex-jvtR_8KSjTnL-xTpCGHr2_zkj3e_nq4WdV397_XNz_vaidbnGvsdLTElew0NtDqAFI7cDoqoXxJb6NS6KMD7yXK6D1IdKpFsoixASsu2frE9RM9m10JR-lgJurN62JKG3P8wg3BkONRCkKtiGRonCZp2yCVp-CkACysHyfWbm-3wbvyZqLhHfS9MvZPZjO9mK7pAFVbAFcngEtTzinEs5eDOXZnzt2J_-2yjjw</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Bernardes, Milton Junior Cândido</creator><creator>Gonçalves, Randys Caldeira</creator><creator>Carvalho, Carolyna de Sousa</creator><creator>Rosa, Luciana Martins</creator><creator>Ferreira, Amanda Peixoto</creator><creator>Vilela, Marielle Sousa</creator><creator>Vinaud, Marina Clare</creator><creator>Galdino Junior, Hélio</creator><creator>Lino Junior, Ruy de Souza</creator><general>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4029-7518</orcidid><orcidid>https://orcid.org/0000-0002-3778-0819</orcidid><orcidid>https://orcid.org/0000-0003-2780-1185</orcidid><orcidid>https://orcid.org/0000-0002-6746-9191</orcidid><orcidid>https://orcid.org/0000-0003-4847-4056</orcidid><orcidid>https://orcid.org/0000-0002-0572-5102</orcidid><orcidid>https://orcid.org/0000-0001-7346-0786</orcidid><orcidid>https://orcid.org/0000-0003-3675-9628</orcidid><orcidid>https://orcid.org/0000-0002-5570-8183</orcidid></search><sort><creationdate>20220101</creationdate><title>Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats</title><author>Bernardes, Milton Junior Cândido ; Gonçalves, Randys Caldeira ; Carvalho, Carolyna de Sousa ; Rosa, Luciana Martins ; Ferreira, Amanda Peixoto ; Vilela, Marielle Sousa ; Vinaud, Marina Clare ; Galdino Junior, Hélio ; Lino Junior, Ruy de Souza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-798fba1649872058e048c0c8f636d613bf667dfc0dd474fdd047c657ab77f20b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Burns</topic><topic>Hydrogels</topic><topic>Original</topic><topic>Rats</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernardes, Milton Junior Cândido</creatorcontrib><creatorcontrib>Gonçalves, Randys Caldeira</creatorcontrib><creatorcontrib>Carvalho, Carolyna de Sousa</creatorcontrib><creatorcontrib>Rosa, Luciana Martins</creatorcontrib><creatorcontrib>Ferreira, Amanda Peixoto</creatorcontrib><creatorcontrib>Vilela, Marielle Sousa</creatorcontrib><creatorcontrib>Vinaud, Marina Clare</creatorcontrib><creatorcontrib>Galdino Junior, Hélio</creatorcontrib><creatorcontrib>Lino Junior, Ruy de Souza</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Acta Cirúrgica Brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernardes, Milton Junior Cândido</au><au>Gonçalves, Randys Caldeira</au><au>Carvalho, Carolyna de Sousa</au><au>Rosa, Luciana Martins</au><au>Ferreira, Amanda Peixoto</au><au>Vilela, Marielle Sousa</au><au>Vinaud, Marina Clare</au><au>Galdino Junior, Hélio</au><au>Lino Junior, Ruy de Souza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats</atitle><jtitle>Acta Cirúrgica Brasileira</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>37</volume><issue>4</issue><issn>0102-8650</issn><eissn>1678-2674</eissn><abstract>ABSTRACT Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats. Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed. Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05). 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| subjects | Burns Hydrogels Original Rats Wound Healing |
| title | Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats |
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