Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Here, we report on a potent class of substituted ureidothiophenes targeting energy-coupling factor (ECF) transporters, an unexplored target that is not addressed by any antibiotic in the market. Since the ECF module is crucial for the vitamin transport mechanism, the prevention of substrate uptake s...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-07, Vol.65 (13), p.8869-8880
Hauptverfasser:	Kiefer, Alexander F., Bousis, Spyridon, Hamed, Mostafa M., Diamanti, Eleonora, Haupenthal, Jörg, Hirsch, Anna K.H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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