Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS

Varicella‐Zoster virus (VZV) causes chickenpox and shingles. Although the infection is associated with severe morbidity in some individuals, molecular mechanisms that determine innate immune responses remain poorly defined. We found that the cGAS/STING DNA sensing pathway was required for type I int...

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Veröffentlicht in:	The EMBO journal 2022-07, Vol.41 (14), p.e109217-n/a
Hauptverfasser:	Hertzog, Jonny, Zhou, Wen, Fowler, Gerissa, Rigby, Rachel E, Bridgeman, Anne, Blest, Henry TW, Cursi, Chiara, Chauveau, Lise, Davenne, Tamara, Warner, Benjamin E, Kinchington, Paul R, Kranzusch, Philip J, Rehwinkel, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	cGAS Chicken pox Confocal microscopy Deoxyribonucleic acid DNA DNA - metabolism DNA sensing EMBO19 EMBO23 Herpes zoster Herpesvirus 3, Human - genetics Herpesvirus 3, Human - immunology Humans Immune response Immunity, Innate Infections Innate immunity Interferon Interferon Type I - immunology Membrane Proteins - immunology Molecular modelling Morbidity Nucleotidyltransferases - antagonists & inhibitors Nucleotidyltransferases - immunology ORF9 phase separation Proteins Recognition Tegument Varicella Varicella‐Zoster virus Viral Proteins - immunology Viruses
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