Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy

Tissue-resident macrophages of the brain, including microglia, are implicated in the pathogenesis of various CNS disorders and are possible therapeutic targets by their chemical depletion or replenishment by hematopoietic stem cell therapy. Nevertheless, a comprehensive understanding of microglial f...

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Veröffentlicht in:	Acta neuropathologica 2022-08, Vol.144 (2), p.211-239
Hauptverfasser:	Berdowski, Woutje M., van der Linde, Herma C., Breur, Marjolein, Oosterhof, Nynke, Beerepoot, Shanice, Sanderson, Leslie, Wijnands, Lieve I., de Jong, Patrick, Tsai-Meu-Chong, Elisa, de Valk, Walter, de Witte, Moniek, van IJcken, Wilfred F. J., Demmers, Jeroen, van der Knaap, Marjo S., Bugiani, Marianna, Wolf, Nicole I., van Ham, Tjakko J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Astrocytes Astrocytes - pathology Brain Cell therapy Colony-stimulating factor Danio rerio Demyelinating Diseases - pathology Endocytosis Health aspects Hematopoietic stem cells Homeostasis Humans Leukodystrophy Leukoencephalopathies - genetics Leukoencephalopathies - pathology Leukoencephalopathy Lysosomal Storage Diseases - metabolism Macrophage colony-stimulating factor Macrophages Medicine Medicine & Public Health Microglia Microglia - pathology Neurodegenerative Diseases - pathology Neuroimaging Neurosciences Original Paper Pathogenesis Pathology Phenotype Phenotypes Proteomics Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Spheroids Stem cells Substantia alba Therapeutic targets Transcriptomics Transplantation Zebrafish Zebrafish Proteins - metabolism
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