Risk of secondary malignancy after radiotherapy for breast cancer: long-term follow-up of Japanese patients with breast cancer
Purpose There have been very few reports of secondary malignancies after breast cancer treatment in Asia, particularly in Japan. This study aimed to evaluate the risk of secondary malignancies after radiotherapy (RT) in Japanese breast cancer patients. Methods This single-center retrospective study...
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| Veröffentlicht in: | Breast cancer research and treatment 2022-08, Vol.194 (3), p.561-567 |
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| creator | Okonogi, Noriyuki Karasawa, Kumiko Nitta, Yuki Mori, Yasumasa Murata, Kazutoshi Wakatsuki, Masaru Tsuji, Hiroshi |
| description | Purpose
There have been very few reports of secondary malignancies after breast cancer treatment in Asia, particularly in Japan. This study aimed to evaluate the risk of secondary malignancies after radiotherapy (RT) in Japanese breast cancer patients.
Methods
This single-center retrospective study included patients who underwent RT between July 1961 and September 2006 for postoperative breast cancer. A total of 702 patients with a follow-up period of more than 5 years were analyzed. All malignancies observed at more than 5 years after the start of RT were defined as secondary malignancies. To calculate the relative risk (RR) of secondary malignancies, we applied data from the National Cancer Center in Japan.
Results
The median observation period was 9.7 (interquartile range 7.1–18.2) years. The cumulative person-years of observation were 6879.4. The RR of contralateral breast cancer increased by 1.85-fold (95% confidence interval [CI] 1.05–3.26) among patients compared with that among the general population; however, the difference was not significant (p = 0.053). The RR of secondary malignancies other than breast cancer increased by 2.71-fold (95% CI 1.99–3.70, p |
| doi_str_mv | 10.1007/s10549-022-06644-x |
| format | Article |
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There have been very few reports of secondary malignancies after breast cancer treatment in Asia, particularly in Japan. This study aimed to evaluate the risk of secondary malignancies after radiotherapy (RT) in Japanese breast cancer patients.
Methods
This single-center retrospective study included patients who underwent RT between July 1961 and September 2006 for postoperative breast cancer. A total of 702 patients with a follow-up period of more than 5 years were analyzed. All malignancies observed at more than 5 years after the start of RT were defined as secondary malignancies. To calculate the relative risk (RR) of secondary malignancies, we applied data from the National Cancer Center in Japan.
Results
The median observation period was 9.7 (interquartile range 7.1–18.2) years. The cumulative person-years of observation were 6879.4. The RR of contralateral breast cancer increased by 1.85-fold (95% confidence interval [CI] 1.05–3.26) among patients compared with that among the general population; however, the difference was not significant (p = 0.053). The RR of secondary malignancies other than breast cancer increased by 2.71-fold (95% CI 1.99–3.70, p < 0.001) among the patients compared with the general population. Even when only malignancies detected more than 10 years after RT were defined as secondary malignancies, the RR of secondary malignancies other than breast cancer was 1.91 (95% CI 1.33–2.73, p < 0.001).
Conclusion
The incidence of secondary malignancies after RT may be somewhat higher in Japanese patients with breast cancer than in the general population.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-022-06644-x</identifier><identifier>PMID: 35781767</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Breast cancer ; Cancer ; Cancer patients ; Cancer research ; Care and treatment ; Clinical Trial ; Malignancy ; Medicine ; Medicine & Public Health ; Oncology ; Oncology, Experimental ; Patients ; Radiation therapy ; Radiotherapy</subject><ispartof>Breast cancer research and treatment, 2022-08, Vol.194 (3), p.561-567</ispartof><rights>The Author(s) 2022</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-96c6ae75d1f7ca7c7f102ff71a97ebb73ef270c5b6d6ae91fd2d2c0e790f5da33</citedby><cites>FETCH-LOGICAL-c593t-96c6ae75d1f7ca7c7f102ff71a97ebb73ef270c5b6d6ae91fd2d2c0e790f5da33</cites><orcidid>0000-0003-1628-8662</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-022-06644-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-022-06644-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Okonogi, Noriyuki</creatorcontrib><creatorcontrib>Karasawa, Kumiko</creatorcontrib><creatorcontrib>Nitta, Yuki</creatorcontrib><creatorcontrib>Mori, Yasumasa</creatorcontrib><creatorcontrib>Murata, Kazutoshi</creatorcontrib><creatorcontrib>Wakatsuki, Masaru</creatorcontrib><creatorcontrib>Tsuji, Hiroshi</creatorcontrib><title>Risk of secondary malignancy after radiotherapy for breast cancer: long-term follow-up of Japanese patients with breast cancer</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
There have been very few reports of secondary malignancies after breast cancer treatment in Asia, particularly in Japan. This study aimed to evaluate the risk of secondary malignancies after radiotherapy (RT) in Japanese breast cancer patients.
Methods
This single-center retrospective study included patients who underwent RT between July 1961 and September 2006 for postoperative breast cancer. A total of 702 patients with a follow-up period of more than 5 years were analyzed. All malignancies observed at more than 5 years after the start of RT were defined as secondary malignancies. To calculate the relative risk (RR) of secondary malignancies, we applied data from the National Cancer Center in Japan.
Results
The median observation period was 9.7 (interquartile range 7.1–18.2) years. The cumulative person-years of observation were 6879.4. The RR of contralateral breast cancer increased by 1.85-fold (95% confidence interval [CI] 1.05–3.26) among patients compared with that among the general population; however, the difference was not significant (p = 0.053). The RR of secondary malignancies other than breast cancer increased by 2.71-fold (95% CI 1.99–3.70, p < 0.001) among the patients compared with the general population. Even when only malignancies detected more than 10 years after RT were defined as secondary malignancies, the RR of secondary malignancies other than breast cancer was 1.91 (95% CI 1.33–2.73, p < 0.001).
Conclusion
The incidence of secondary malignancies after RT may be somewhat higher in Japanese patients with breast cancer than in the general population.</description><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer research</subject><subject>Care and treatment</subject><subject>Clinical Trial</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9klFrFDEUhQdR7Fr9Az4FBPFlapLZmWx8EErRqhQE0eeQydzMpGaSMZlpuy_-du92i3VFJA-B3O-c5N6conjO6AmjVLzOjNZrWVLOS9o063V586BYsVpUpeBMPCxWlDWibDa0OSqe5HxJKZWCysfFUVWLDRONWBU_v7j8nURLMpgYOp22ZNTe9UEHsyXazpBI0p2L8wBJT1tiYyJtAp1nYpCB9Ib4GPoSwRGL3sfrcpl2jp_0pANkIJOeHYQ5k2s3D4fip8Ujq32GZ3f7cfHt_buvZx_Ki8_nH89OL0pTy2ouZWMaDaLumBVGCyMso9xawbQU0LaiAssFNXXbdMhJZjvecUNBSGrrTlfVcfF27zst7Qidweck7dWU3Igtq6idOqwEN6g-XinJNzhMhgav7gxS_LFAntXosgHvscW4ZMWbTU2rGqeK6Iu_0Mu4pIDt7SgpN6Li8p7qtQflgo14r9mZqlPB6JpKtELq5B8Urg5Ghx8G1uH5geDlH4IBtJ-HHP0yuxjyIcj3oEkx5wT29zAYVbt4qX28FMZL3cZL3aCo2osywqGHdN_af1S_AGZp0yQ</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Okonogi, Noriyuki</creator><creator>Karasawa, Kumiko</creator><creator>Nitta, Yuki</creator><creator>Mori, Yasumasa</creator><creator>Murata, Kazutoshi</creator><creator>Wakatsuki, Masaru</creator><creator>Tsuji, Hiroshi</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1628-8662</orcidid></search><sort><creationdate>20220801</creationdate><title>Risk of secondary malignancy after radiotherapy for breast cancer: long-term follow-up of Japanese patients with breast cancer</title><author>Okonogi, Noriyuki ; Karasawa, Kumiko ; Nitta, Yuki ; Mori, Yasumasa ; Murata, Kazutoshi ; Wakatsuki, Masaru ; Tsuji, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-96c6ae75d1f7ca7c7f102ff71a97ebb73ef270c5b6d6ae91fd2d2c0e790f5da33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer research</topic><topic>Care and treatment</topic><topic>Clinical Trial</topic><topic>Malignancy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okonogi, Noriyuki</creatorcontrib><creatorcontrib>Karasawa, Kumiko</creatorcontrib><creatorcontrib>Nitta, Yuki</creatorcontrib><creatorcontrib>Mori, Yasumasa</creatorcontrib><creatorcontrib>Murata, Kazutoshi</creatorcontrib><creatorcontrib>Wakatsuki, Masaru</creatorcontrib><creatorcontrib>Tsuji, Hiroshi</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okonogi, Noriyuki</au><au>Karasawa, Kumiko</au><au>Nitta, Yuki</au><au>Mori, Yasumasa</au><au>Murata, Kazutoshi</au><au>Wakatsuki, Masaru</au><au>Tsuji, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of secondary malignancy after radiotherapy for breast cancer: long-term follow-up of Japanese patients with breast cancer</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>194</volume><issue>3</issue><spage>561</spage><epage>567</epage><pages>561-567</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><abstract>Purpose
There have been very few reports of secondary malignancies after breast cancer treatment in Asia, particularly in Japan. This study aimed to evaluate the risk of secondary malignancies after radiotherapy (RT) in Japanese breast cancer patients.
Methods
This single-center retrospective study included patients who underwent RT between July 1961 and September 2006 for postoperative breast cancer. A total of 702 patients with a follow-up period of more than 5 years were analyzed. All malignancies observed at more than 5 years after the start of RT were defined as secondary malignancies. To calculate the relative risk (RR) of secondary malignancies, we applied data from the National Cancer Center in Japan.
Results
The median observation period was 9.7 (interquartile range 7.1–18.2) years. The cumulative person-years of observation were 6879.4. The RR of contralateral breast cancer increased by 1.85-fold (95% confidence interval [CI] 1.05–3.26) among patients compared with that among the general population; however, the difference was not significant (p = 0.053). The RR of secondary malignancies other than breast cancer increased by 2.71-fold (95% CI 1.99–3.70, p < 0.001) among the patients compared with the general population. Even when only malignancies detected more than 10 years after RT were defined as secondary malignancies, the RR of secondary malignancies other than breast cancer was 1.91 (95% CI 1.33–2.73, p < 0.001).
Conclusion
The incidence of secondary malignancies after RT may be somewhat higher in Japanese patients with breast cancer than in the general population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35781767</pmid><doi>10.1007/s10549-022-06644-x</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1628-8662</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Breast cancer Cancer Cancer patients Cancer research Care and treatment Clinical Trial Malignancy Medicine Medicine & Public Health Oncology Oncology, Experimental Patients Radiation therapy Radiotherapy |
| title | Risk of secondary malignancy after radiotherapy for breast cancer: long-term follow-up of Japanese patients with breast cancer |
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