The healing dynamics of non‐healing wounds using cryo‐preserved amniotic membrane
We evaluated the effect of the application of cryo‐preserved amniotic membrane on the healing of 26 non‐healing wounds (18 patients) with varying aetiologies and baseline sizes (average of 15.4 cm2), which had resisted the standard of care treatment for 6 to 456 weeks (average 88.8 weeks). Based on...
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| Veröffentlicht in: | International wound journal 2022-08, Vol.19 (5), p.1243-1252 |
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| creator | Svobodova, Alzbeta Horvath, Vojtech Smeringaiova, Ingrida Cabral, Joao Victor Zemlickova, Martina Fiala, Radovan Burkert, Jan Nemetova, Denisa Stadler, Petr Lindner, Jaroslav Bednar, Jan Jirsova, Katerina |
| description | We evaluated the effect of the application of cryo‐preserved amniotic membrane on the healing of 26 non‐healing wounds (18 patients) with varying aetiologies and baseline sizes (average of 15.4 cm2), which had resisted the standard of care treatment for 6 to 456 weeks (average 88.8 weeks). Based on their average general responses to the application of cryo‐preserved AM, we could differentiate three wound groups. The first healed group was characterised by complete healing (100% wound closure, maximum treatment period 38 weeks) and represented 62% of treated wounds. The wound area reduction of at least 50% was reached for all wounds in this group within the first 10 weeks of treatment. Exactly 19% of the studied wounds responded partially to the treatment (partially healed group), reaching less than 25% of closure in the first 10 weeks and 90% at maximum for extended treatment period (up to 78 weeks). The remaining 19% of treated wounds did not show any reaction to the AM application (unhealed defects). The three groups have different profiles of wound area reduction, which can be used as a guideline in predicting the healing prognosis of non‐healing wounds treated with a cryo‐preserved amniotic membrane. |
| doi_str_mv | 10.1111/iwj.13719 |
| format | Article |
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Based on their average general responses to the application of cryo‐preserved AM, we could differentiate three wound groups. The first healed group was characterised by complete healing (100% wound closure, maximum treatment period 38 weeks) and represented 62% of treated wounds. The wound area reduction of at least 50% was reached for all wounds in this group within the first 10 weeks of treatment. Exactly 19% of the studied wounds responded partially to the treatment (partially healed group), reaching less than 25% of closure in the first 10 weeks and 90% at maximum for extended treatment period (up to 78 weeks). The remaining 19% of treated wounds did not show any reaction to the AM application (unhealed defects). The three groups have different profiles of wound area reduction, which can be used as a guideline in predicting the healing prognosis of non‐healing wounds treated with a cryo‐preserved amniotic membrane.</description><identifier>ISSN: 1742-4801</identifier><identifier>EISSN: 1742-481X</identifier><identifier>DOI: 10.1111/iwj.13719</identifier><identifier>PMID: 34791774</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anemia ; Ankle ; Antibiotics ; Cardiac arrhythmia ; Care and treatment ; cryo‐preserved amniotic membrane ; Debridement ; Diabetes ; Efficiency ; Glycerol ; healing dynamics ; Hospitals ; Hypertension ; non‐healing wounds ; Original ; Physiology ; Quality of life ; Vein & artery diseases ; Wound healing ; Wounds and injuries</subject><ispartof>International wound journal, 2022-08, Vol.19 (5), p.1243-1252</ispartof><rights>2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.</rights><rights>COPYRIGHT 2022 John Wiley & Sons, Inc.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4879-715f993023717ec287269aac368ed5f85724c43a36331e713362196a3e97aba23</citedby><cites>FETCH-LOGICAL-c4879-715f993023717ec287269aac368ed5f85724c43a36331e713362196a3e97aba23</cites><orcidid>0000-0002-4625-6701</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284646/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284646/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1416,11560,27922,27923,45572,45573,46050,46474,53789,53791</link.rule.ids></links><search><creatorcontrib>Svobodova, Alzbeta</creatorcontrib><creatorcontrib>Horvath, Vojtech</creatorcontrib><creatorcontrib>Smeringaiova, Ingrida</creatorcontrib><creatorcontrib>Cabral, Joao Victor</creatorcontrib><creatorcontrib>Zemlickova, Martina</creatorcontrib><creatorcontrib>Fiala, Radovan</creatorcontrib><creatorcontrib>Burkert, Jan</creatorcontrib><creatorcontrib>Nemetova, Denisa</creatorcontrib><creatorcontrib>Stadler, Petr</creatorcontrib><creatorcontrib>Lindner, Jaroslav</creatorcontrib><creatorcontrib>Bednar, Jan</creatorcontrib><creatorcontrib>Jirsova, Katerina</creatorcontrib><title>The healing dynamics of non‐healing wounds using cryo‐preserved amniotic membrane</title><title>International wound journal</title><description>We evaluated the effect of the application of cryo‐preserved amniotic membrane on the healing of 26 non‐healing wounds (18 patients) with varying aetiologies and baseline sizes (average of 15.4 cm2), which had resisted the standard of care treatment for 6 to 456 weeks (average 88.8 weeks). Based on their average general responses to the application of cryo‐preserved AM, we could differentiate three wound groups. The first healed group was characterised by complete healing (100% wound closure, maximum treatment period 38 weeks) and represented 62% of treated wounds. The wound area reduction of at least 50% was reached for all wounds in this group within the first 10 weeks of treatment. Exactly 19% of the studied wounds responded partially to the treatment (partially healed group), reaching less than 25% of closure in the first 10 weeks and 90% at maximum for extended treatment period (up to 78 weeks). The remaining 19% of treated wounds did not show any reaction to the AM application (unhealed defects). The three groups have different profiles of wound area reduction, which can be used as a guideline in predicting the healing prognosis of non‐healing wounds treated with a cryo‐preserved amniotic membrane.</description><subject>Anemia</subject><subject>Ankle</subject><subject>Antibiotics</subject><subject>Cardiac arrhythmia</subject><subject>Care and treatment</subject><subject>cryo‐preserved amniotic membrane</subject><subject>Debridement</subject><subject>Diabetes</subject><subject>Efficiency</subject><subject>Glycerol</subject><subject>healing dynamics</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>non‐healing wounds</subject><subject>Original</subject><subject>Physiology</subject><subject>Quality of life</subject><subject>Vein & artery diseases</subject><subject>Wound healing</subject><subject>Wounds and injuries</subject><issn>1742-4801</issn><issn>1742-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1ks1OGzEQx60KVCj00DdYiQs9JPhr7fWlEkKlUCFxAZWb5XhnE0e7dmpniXLjEXhGngRvA5FA1D547PnNf2asQegbwWOS14lbzceESaI-oX0iOR3xitztbG1M9tCXlOYYU1WW8jPaY1wqIiXfR7c3MyhmYFrnp0W99qZzNhWhKXzwTw-Pr55V6H2dij4NFxvXIfsWERLEe6gL03kXls4WHXSTaDwcot3GtAm-vpwH6Pb8583Zxejq-tfl2enVyPJKqpEkZaMUwzTXLsHSSlKhjLFMVFCXTVVKyi1nhgnGCEjCmKBECcNASTMxlB2gHxvdRT_poLbgl9G0ehFdZ-JaB-P0W493Mz0N91rRigsussDxi0AMf3tIS925ZKFtcxOhT5qWSmHJqnLIdfQOnYc--tyeZlhhgZXIZW6pqWlBO9-EnNcOovpUcsJKVZGBGn9A5V1D_v_goXH5_U3A902AjSGlCM22R4L1MAM6z4D-NwOZPdmwqyyy_j-oL__83kQ8A7tRsck</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Svobodova, Alzbeta</creator><creator>Horvath, Vojtech</creator><creator>Smeringaiova, Ingrida</creator><creator>Cabral, Joao Victor</creator><creator>Zemlickova, Martina</creator><creator>Fiala, Radovan</creator><creator>Burkert, Jan</creator><creator>Nemetova, Denisa</creator><creator>Stadler, Petr</creator><creator>Lindner, Jaroslav</creator><creator>Bednar, Jan</creator><creator>Jirsova, Katerina</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4625-6701</orcidid></search><sort><creationdate>202208</creationdate><title>The healing dynamics of non‐healing wounds using cryo‐preserved amniotic membrane</title><author>Svobodova, Alzbeta ; Horvath, Vojtech ; Smeringaiova, Ingrida ; Cabral, Joao Victor ; Zemlickova, Martina ; Fiala, Radovan ; Burkert, Jan ; Nemetova, Denisa ; Stadler, Petr ; Lindner, Jaroslav ; Bednar, Jan ; Jirsova, Katerina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4879-715f993023717ec287269aac368ed5f85724c43a36331e713362196a3e97aba23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anemia</topic><topic>Ankle</topic><topic>Antibiotics</topic><topic>Cardiac arrhythmia</topic><topic>Care and treatment</topic><topic>cryo‐preserved amniotic membrane</topic><topic>Debridement</topic><topic>Diabetes</topic><topic>Efficiency</topic><topic>Glycerol</topic><topic>healing dynamics</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>non‐healing wounds</topic><topic>Original</topic><topic>Physiology</topic><topic>Quality of life</topic><topic>Vein & artery diseases</topic><topic>Wound healing</topic><topic>Wounds and injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Svobodova, Alzbeta</creatorcontrib><creatorcontrib>Horvath, Vojtech</creatorcontrib><creatorcontrib>Smeringaiova, Ingrida</creatorcontrib><creatorcontrib>Cabral, Joao Victor</creatorcontrib><creatorcontrib>Zemlickova, Martina</creatorcontrib><creatorcontrib>Fiala, Radovan</creatorcontrib><creatorcontrib>Burkert, Jan</creatorcontrib><creatorcontrib>Nemetova, Denisa</creatorcontrib><creatorcontrib>Stadler, Petr</creatorcontrib><creatorcontrib>Lindner, Jaroslav</creatorcontrib><creatorcontrib>Bednar, Jan</creatorcontrib><creatorcontrib>Jirsova, Katerina</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International wound journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Svobodova, Alzbeta</au><au>Horvath, Vojtech</au><au>Smeringaiova, Ingrida</au><au>Cabral, Joao Victor</au><au>Zemlickova, Martina</au><au>Fiala, Radovan</au><au>Burkert, Jan</au><au>Nemetova, Denisa</au><au>Stadler, Petr</au><au>Lindner, Jaroslav</au><au>Bednar, Jan</au><au>Jirsova, Katerina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The healing dynamics of non‐healing wounds using cryo‐preserved amniotic membrane</atitle><jtitle>International wound journal</jtitle><date>2022-08</date><risdate>2022</risdate><volume>19</volume><issue>5</issue><spage>1243</spage><epage>1252</epage><pages>1243-1252</pages><issn>1742-4801</issn><eissn>1742-481X</eissn><abstract>We evaluated the effect of the application of cryo‐preserved amniotic membrane on the healing of 26 non‐healing wounds (18 patients) with varying aetiologies and baseline sizes (average of 15.4 cm2), which had resisted the standard of care treatment for 6 to 456 weeks (average 88.8 weeks). Based on their average general responses to the application of cryo‐preserved AM, we could differentiate three wound groups. The first healed group was characterised by complete healing (100% wound closure, maximum treatment period 38 weeks) and represented 62% of treated wounds. The wound area reduction of at least 50% was reached for all wounds in this group within the first 10 weeks of treatment. Exactly 19% of the studied wounds responded partially to the treatment (partially healed group), reaching less than 25% of closure in the first 10 weeks and 90% at maximum for extended treatment period (up to 78 weeks). The remaining 19% of treated wounds did not show any reaction to the AM application (unhealed defects). The three groups have different profiles of wound area reduction, which can be used as a guideline in predicting the healing prognosis of non‐healing wounds treated with a cryo‐preserved amniotic membrane.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>34791774</pmid><doi>10.1111/iwj.13719</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4625-6701</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anemia Ankle Antibiotics Cardiac arrhythmia Care and treatment cryo‐preserved amniotic membrane Debridement Diabetes Efficiency Glycerol healing dynamics Hospitals Hypertension non‐healing wounds Original Physiology Quality of life Vein & artery diseases Wound healing Wounds and injuries |
| title | The healing dynamics of non‐healing wounds using cryo‐preserved amniotic membrane |
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