Occurrence of peritoneal carcinomatosis in patients with rectal cancer undergoing staging pelvic MRI: clinical observations
Objectives Describe the cumulative incidence (CUIN) of peritoneal carcinomatosis (PC) and survival in patients presenting with advanced rectal cancer at staging pelvic MRI. Methods From 2013 to 2018, clinicopathologic records of patients with pretreatment rectal MRI clinical (c)T3c, cT3d, cT4a, and...
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| Veröffentlicht in: | European radiology 2022-08, Vol.32 (8), p.5097-5105 |
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| creator | Gollub, Marc J. Lobaugh, Stephanie Golia Pernicka, Jennifer S. Simmers, Cameron D. A. Bates, David D. B. Fuqua, J. Louis Paroder, Viktoriya Petkovska, Iva Weiser, Martin R. Capanu, Marinela |
| description | Objectives
Describe the cumulative incidence (CUIN) of peritoneal carcinomatosis (PC) and survival in patients presenting with advanced rectal cancer at staging pelvic MRI.
Methods
From 2013 to 2018, clinicopathologic records of patients with pretreatment rectal MRI clinical (c)T3c, cT3d, cT4a, and cT4b primary rectal adenocarcinoma were retrospectively reviewed by two radiologists. Standard MRI descriptors and pathologic stages were recorded. Recurrence-free (RFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Development of PC was explored using competing risk analysis. Differences in survival were compared using the log-rank test. Gray’s test was used to test for differences in CUIN of PC.
Results
Three hundred forty-three patients (147 women; median age, 56 years) had MRI stages cT3cd,
n
= 170; cT4a,
n
= 40; and cT4b,
n
= 133. Median follow-up among survivors was 27 months (0.36–70 months). For M1 patients, OS differed only by cT stage (2-year OS: cT3 88.1%, cT4a 79.1%, cT4b 64.7%,
p
= 0.045). For M0 patients, OS and RFS differed only by pathological (p)T stage. We observed a statistically significant difference in the cumulative incidence of PC by cT stage (2-year CUIN: cT3 3.2%, cT4a 8.5%, cT4b 1.6%,
p
= 0.01), but not by pT stage. Seventy-nine patients (23%) presented with metastatic disease (M1), eight with PC (2.3%). Overall, eight patients presented with PC (cT4a:
n
= 4, other stages:
n
= 4) and 22 developed PC (cT4a:
n
= 5, other stages:
n
= 17).
Conclusions
PC is uncommon in rectal cancer. MRI–based T stage exhibited an overall association with the cumulative incidence of PC, and descriptively, cT4a stage appears to have the highest CUIN.
Key Points
•
In a retrospective study of 343 patients with rectal cancer undergoing baseline MRI and clinical follow-up, we found that peritoneal carcinomatosis was rare.
•
We observed a significant overall association between PC at presentation and cT stage that appeared to be driven by the higher proportion of cT4a patients presenting with PC.
•
Among patients that did not present with PC, we observed a significant overall association between time to PC and cT stage that may be driven by the higher cumulative incidence of PC in cT4a patients. |
| doi_str_mv | 10.1007/s00330-022-08694-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9283216</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2688768448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-81b7152468f795b2fcad82d26d7a2dc38ce4bb752112b815ec70eae0b6bc8d913</originalsourceid><addsrcrecordid>eNp9kc1rFTEUxYNYbK3-Ay4k4KabsfmaScaFIMWPQqUgug5J5s40ZV4yJpknxX_evL5aqwtXN3B_5-QeDkIvKHlNCZGnmRDOSUMYa4jqetHIR-iICs4aSpR4_OB9iJ7mfE0I6amQT9AhbzntiZRH6Oelc2tKEBzgOOIFki8xgJmxM8n5EDemxOwz9gEvpngIJeMfvlzhBK7cYlWa8BoGSFP0YcK5mGk3F5i33uHPX87fYDf74F3Fo82QttUohvwMHYxmzvD8bh6jbx_efz371Fxcfjw_e3fROCFFaRS1krZMdGqUfWvZ6Myg2MC6QRo2OK4cCGtlyyhlVtEWnCRggNjOOjX0lB-jt3vfZbUbGFzNkMysl-Q3Jt3oaLz-exP8lZ7iVvdMcUa7anByZ5Di9xVy0RufHcyzCRDXrFknGK8HElXRV_-g13FNocarlFKyU0LsKLanXIo5Jxjvj6FE77rV-2517VbfdqtlFb18GONe8rvMCvA9kOsqTJD-_P0f219cNLK4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2688768448</pqid></control><display><type>article</type><title>Occurrence of peritoneal carcinomatosis in patients with rectal cancer undergoing staging pelvic MRI: clinical observations</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gollub, Marc J. ; Lobaugh, Stephanie ; Golia Pernicka, Jennifer S. ; Simmers, Cameron D. A. ; Bates, David D. B. ; Fuqua, J. Louis ; Paroder, Viktoriya ; Petkovska, Iva ; Weiser, Martin R. ; Capanu, Marinela</creator><creatorcontrib>Gollub, Marc J. ; Lobaugh, Stephanie ; Golia Pernicka, Jennifer S. ; Simmers, Cameron D. A. ; Bates, David D. B. ; Fuqua, J. Louis ; Paroder, Viktoriya ; Petkovska, Iva ; Weiser, Martin R. ; Capanu, Marinela</creatorcontrib><description>Objectives
Describe the cumulative incidence (CUIN) of peritoneal carcinomatosis (PC) and survival in patients presenting with advanced rectal cancer at staging pelvic MRI.
Methods
From 2013 to 2018, clinicopathologic records of patients with pretreatment rectal MRI clinical (c)T3c, cT3d, cT4a, and cT4b primary rectal adenocarcinoma were retrospectively reviewed by two radiologists. Standard MRI descriptors and pathologic stages were recorded. Recurrence-free (RFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Development of PC was explored using competing risk analysis. Differences in survival were compared using the log-rank test. Gray’s test was used to test for differences in CUIN of PC.
Results
Three hundred forty-three patients (147 women; median age, 56 years) had MRI stages cT3cd,
n
= 170; cT4a,
n
= 40; and cT4b,
n
= 133. Median follow-up among survivors was 27 months (0.36–70 months). For M1 patients, OS differed only by cT stage (2-year OS: cT3 88.1%, cT4a 79.1%, cT4b 64.7%,
p
= 0.045). For M0 patients, OS and RFS differed only by pathological (p)T stage. We observed a statistically significant difference in the cumulative incidence of PC by cT stage (2-year CUIN: cT3 3.2%, cT4a 8.5%, cT4b 1.6%,
p
= 0.01), but not by pT stage. Seventy-nine patients (23%) presented with metastatic disease (M1), eight with PC (2.3%). Overall, eight patients presented with PC (cT4a:
n
= 4, other stages:
n
= 4) and 22 developed PC (cT4a:
n
= 5, other stages:
n
= 17).
Conclusions
PC is uncommon in rectal cancer. MRI–based T stage exhibited an overall association with the cumulative incidence of PC, and descriptively, cT4a stage appears to have the highest CUIN.
Key Points
•
In a retrospective study of 343 patients with rectal cancer undergoing baseline MRI and clinical follow-up, we found that peritoneal carcinomatosis was rare.
•
We observed a significant overall association between PC at presentation and cT stage that appeared to be driven by the higher proportion of cT4a patients presenting with PC.
•
Among patients that did not present with PC, we observed a significant overall association between time to PC and cT stage that may be driven by the higher cumulative incidence of PC in cT4a patients.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-022-08694-7</identifier><identifier>PMID: 35319077</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenocarcinoma ; Cancer ; Colorectal cancer ; Diagnostic Radiology ; Female ; Gastric cancer ; Gastrointestinal ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance Imaging ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Metastases ; Middle Aged ; Neoplasm Staging ; Neuroradiology ; Patients ; Peritoneal Neoplasms - diagnostic imaging ; Peritoneal Neoplasms - epidemiology ; Peritoneal Neoplasms - pathology ; Peritoneum ; Radiology ; Rank tests ; Rectal Neoplasms - diagnostic imaging ; Rectal Neoplasms - pathology ; Rectum ; Retrospective Studies ; Risk analysis ; Statistical analysis ; Survival ; Ultrasound</subject><ispartof>European radiology, 2022-08, Vol.32 (8), p.5097-5105</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2022</rights><rights>2022. The Author(s), under exclusive licence to European Society of Radiology.</rights><rights>The Author(s), under exclusive licence to European Society of Radiology 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-81b7152468f795b2fcad82d26d7a2dc38ce4bb752112b815ec70eae0b6bc8d913</citedby><cites>FETCH-LOGICAL-c474t-81b7152468f795b2fcad82d26d7a2dc38ce4bb752112b815ec70eae0b6bc8d913</cites><orcidid>0000-0002-6008-0730</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-022-08694-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-022-08694-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35319077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gollub, Marc J.</creatorcontrib><creatorcontrib>Lobaugh, Stephanie</creatorcontrib><creatorcontrib>Golia Pernicka, Jennifer S.</creatorcontrib><creatorcontrib>Simmers, Cameron D. A.</creatorcontrib><creatorcontrib>Bates, David D. B.</creatorcontrib><creatorcontrib>Fuqua, J. Louis</creatorcontrib><creatorcontrib>Paroder, Viktoriya</creatorcontrib><creatorcontrib>Petkovska, Iva</creatorcontrib><creatorcontrib>Weiser, Martin R.</creatorcontrib><creatorcontrib>Capanu, Marinela</creatorcontrib><title>Occurrence of peritoneal carcinomatosis in patients with rectal cancer undergoing staging pelvic MRI: clinical observations</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
Describe the cumulative incidence (CUIN) of peritoneal carcinomatosis (PC) and survival in patients presenting with advanced rectal cancer at staging pelvic MRI.
Methods
From 2013 to 2018, clinicopathologic records of patients with pretreatment rectal MRI clinical (c)T3c, cT3d, cT4a, and cT4b primary rectal adenocarcinoma were retrospectively reviewed by two radiologists. Standard MRI descriptors and pathologic stages were recorded. Recurrence-free (RFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Development of PC was explored using competing risk analysis. Differences in survival were compared using the log-rank test. Gray’s test was used to test for differences in CUIN of PC.
Results
Three hundred forty-three patients (147 women; median age, 56 years) had MRI stages cT3cd,
n
= 170; cT4a,
n
= 40; and cT4b,
n
= 133. Median follow-up among survivors was 27 months (0.36–70 months). For M1 patients, OS differed only by cT stage (2-year OS: cT3 88.1%, cT4a 79.1%, cT4b 64.7%,
p
= 0.045). For M0 patients, OS and RFS differed only by pathological (p)T stage. We observed a statistically significant difference in the cumulative incidence of PC by cT stage (2-year CUIN: cT3 3.2%, cT4a 8.5%, cT4b 1.6%,
p
= 0.01), but not by pT stage. Seventy-nine patients (23%) presented with metastatic disease (M1), eight with PC (2.3%). Overall, eight patients presented with PC (cT4a:
n
= 4, other stages:
n
= 4) and 22 developed PC (cT4a:
n
= 5, other stages:
n
= 17).
Conclusions
PC is uncommon in rectal cancer. MRI–based T stage exhibited an overall association with the cumulative incidence of PC, and descriptively, cT4a stage appears to have the highest CUIN.
Key Points
•
In a retrospective study of 343 patients with rectal cancer undergoing baseline MRI and clinical follow-up, we found that peritoneal carcinomatosis was rare.
•
We observed a significant overall association between PC at presentation and cT stage that appeared to be driven by the higher proportion of cT4a patients presenting with PC.
•
Among patients that did not present with PC, we observed a significant overall association between time to PC and cT stage that may be driven by the higher cumulative incidence of PC in cT4a patients.</description><subject>Adenocarcinoma</subject><subject>Cancer</subject><subject>Colorectal cancer</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastrointestinal</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Peritoneal Neoplasms - diagnostic imaging</subject><subject>Peritoneal Neoplasms - epidemiology</subject><subject>Peritoneal Neoplasms - pathology</subject><subject>Peritoneum</subject><subject>Radiology</subject><subject>Rank tests</subject><subject>Rectal Neoplasms - diagnostic imaging</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectum</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Statistical analysis</subject><subject>Survival</subject><subject>Ultrasound</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1rFTEUxYNYbK3-Ay4k4KabsfmaScaFIMWPQqUgug5J5s40ZV4yJpknxX_evL5aqwtXN3B_5-QeDkIvKHlNCZGnmRDOSUMYa4jqetHIR-iICs4aSpR4_OB9iJ7mfE0I6amQT9AhbzntiZRH6Oelc2tKEBzgOOIFki8xgJmxM8n5EDemxOwz9gEvpngIJeMfvlzhBK7cYlWa8BoGSFP0YcK5mGk3F5i33uHPX87fYDf74F3Fo82QttUohvwMHYxmzvD8bh6jbx_efz371Fxcfjw_e3fROCFFaRS1krZMdGqUfWvZ6Myg2MC6QRo2OK4cCGtlyyhlVtEWnCRggNjOOjX0lB-jt3vfZbUbGFzNkMysl-Q3Jt3oaLz-exP8lZ7iVvdMcUa7anByZ5Di9xVy0RufHcyzCRDXrFknGK8HElXRV_-g13FNocarlFKyU0LsKLanXIo5Jxjvj6FE77rV-2517VbfdqtlFb18GONe8rvMCvA9kOsqTJD-_P0f219cNLK4</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Gollub, Marc J.</creator><creator>Lobaugh, Stephanie</creator><creator>Golia Pernicka, Jennifer S.</creator><creator>Simmers, Cameron D. A.</creator><creator>Bates, David D. B.</creator><creator>Fuqua, J. Louis</creator><creator>Paroder, Viktoriya</creator><creator>Petkovska, Iva</creator><creator>Weiser, Martin R.</creator><creator>Capanu, Marinela</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6008-0730</orcidid></search><sort><creationdate>20220801</creationdate><title>Occurrence of peritoneal carcinomatosis in patients with rectal cancer undergoing staging pelvic MRI: clinical observations</title><author>Gollub, Marc J. ; Lobaugh, Stephanie ; Golia Pernicka, Jennifer S. ; Simmers, Cameron D. A. ; Bates, David D. B. ; Fuqua, J. Louis ; Paroder, Viktoriya ; Petkovska, Iva ; Weiser, Martin R. ; Capanu, Marinela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-81b7152468f795b2fcad82d26d7a2dc38ce4bb752112b815ec70eae0b6bc8d913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Cancer</topic><topic>Colorectal cancer</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastrointestinal</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neuroradiology</topic><topic>Patients</topic><topic>Peritoneal Neoplasms - diagnostic imaging</topic><topic>Peritoneal Neoplasms - epidemiology</topic><topic>Peritoneal Neoplasms - pathology</topic><topic>Peritoneum</topic><topic>Radiology</topic><topic>Rank tests</topic><topic>Rectal Neoplasms - diagnostic imaging</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectum</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Statistical analysis</topic><topic>Survival</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gollub, Marc J.</creatorcontrib><creatorcontrib>Lobaugh, Stephanie</creatorcontrib><creatorcontrib>Golia Pernicka, Jennifer S.</creatorcontrib><creatorcontrib>Simmers, Cameron D. A.</creatorcontrib><creatorcontrib>Bates, David D. B.</creatorcontrib><creatorcontrib>Fuqua, J. Louis</creatorcontrib><creatorcontrib>Paroder, Viktoriya</creatorcontrib><creatorcontrib>Petkovska, Iva</creatorcontrib><creatorcontrib>Weiser, Martin R.</creatorcontrib><creatorcontrib>Capanu, Marinela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gollub, Marc J.</au><au>Lobaugh, Stephanie</au><au>Golia Pernicka, Jennifer S.</au><au>Simmers, Cameron D. A.</au><au>Bates, David D. B.</au><au>Fuqua, J. Louis</au><au>Paroder, Viktoriya</au><au>Petkovska, Iva</au><au>Weiser, Martin R.</au><au>Capanu, Marinela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occurrence of peritoneal carcinomatosis in patients with rectal cancer undergoing staging pelvic MRI: clinical observations</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>32</volume><issue>8</issue><spage>5097</spage><epage>5105</epage><pages>5097-5105</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
Describe the cumulative incidence (CUIN) of peritoneal carcinomatosis (PC) and survival in patients presenting with advanced rectal cancer at staging pelvic MRI.
Methods
From 2013 to 2018, clinicopathologic records of patients with pretreatment rectal MRI clinical (c)T3c, cT3d, cT4a, and cT4b primary rectal adenocarcinoma were retrospectively reviewed by two radiologists. Standard MRI descriptors and pathologic stages were recorded. Recurrence-free (RFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Development of PC was explored using competing risk analysis. Differences in survival were compared using the log-rank test. Gray’s test was used to test for differences in CUIN of PC.
Results
Three hundred forty-three patients (147 women; median age, 56 years) had MRI stages cT3cd,
n
= 170; cT4a,
n
= 40; and cT4b,
n
= 133. Median follow-up among survivors was 27 months (0.36–70 months). For M1 patients, OS differed only by cT stage (2-year OS: cT3 88.1%, cT4a 79.1%, cT4b 64.7%,
p
= 0.045). For M0 patients, OS and RFS differed only by pathological (p)T stage. We observed a statistically significant difference in the cumulative incidence of PC by cT stage (2-year CUIN: cT3 3.2%, cT4a 8.5%, cT4b 1.6%,
p
= 0.01), but not by pT stage. Seventy-nine patients (23%) presented with metastatic disease (M1), eight with PC (2.3%). Overall, eight patients presented with PC (cT4a:
n
= 4, other stages:
n
= 4) and 22 developed PC (cT4a:
n
= 5, other stages:
n
= 17).
Conclusions
PC is uncommon in rectal cancer. MRI–based T stage exhibited an overall association with the cumulative incidence of PC, and descriptively, cT4a stage appears to have the highest CUIN.
Key Points
•
In a retrospective study of 343 patients with rectal cancer undergoing baseline MRI and clinical follow-up, we found that peritoneal carcinomatosis was rare.
•
We observed a significant overall association between PC at presentation and cT stage that appeared to be driven by the higher proportion of cT4a patients presenting with PC.
•
Among patients that did not present with PC, we observed a significant overall association between time to PC and cT stage that may be driven by the higher cumulative incidence of PC in cT4a patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35319077</pmid><doi>10.1007/s00330-022-08694-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6008-0730</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-1084 |
| ispartof | European radiology, 2022-08, Vol.32 (8), p.5097-5105 |
| issn | 1432-1084 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9283216 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma Cancer Colorectal cancer Diagnostic Radiology Female Gastric cancer Gastrointestinal Humans Imaging Internal Medicine Interventional Radiology Magnetic Resonance Imaging Medical diagnosis Medicine Medicine & Public Health Metastases Middle Aged Neoplasm Staging Neuroradiology Patients Peritoneal Neoplasms - diagnostic imaging Peritoneal Neoplasms - epidemiology Peritoneal Neoplasms - pathology Peritoneum Radiology Rank tests Rectal Neoplasms - diagnostic imaging Rectal Neoplasms - pathology Rectum Retrospective Studies Risk analysis Statistical analysis Survival Ultrasound |
| title | Occurrence of peritoneal carcinomatosis in patients with rectal cancer undergoing staging pelvic MRI: clinical observations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A15%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Occurrence%20of%20peritoneal%20carcinomatosis%20in%20patients%20with%20rectal%20cancer%20undergoing%20staging%20pelvic%20MRI:%20clinical%20observations&rft.jtitle=European%20radiology&rft.au=Gollub,%20Marc%20J.&rft.date=2022-08-01&rft.volume=32&rft.issue=8&rft.spage=5097&rft.epage=5105&rft.pages=5097-5105&rft.issn=1432-1084&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-022-08694-7&rft_dat=%3Cproquest_pubme%3E2688768448%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2688768448&rft_id=info:pmid/35319077&rfr_iscdi=true |