Accelerated epigenetic aging in newborns with Down syndrome

Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brain tissue of adults with DS but when premature...

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Veröffentlicht in:	Aging cell 2022-07, Vol.21 (7), p.e13652-n/a
Hauptverfasser:	Xu, Keren, Li, Shaobo, Muskens, Ivo S., Elliott, Natalina, Myint, Swe Swe, Pandey, Priyatama, Hansen, Helen M., Morimoto, Libby M., Kang, Alice Y., Ma, Xiaomei, Metayer, Catherine, Mueller, Beth A., Roberts, Irene, Walsh, Kyle M., Horvath, Steve, Wiemels, Joseph L., Smith, Adam J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging Aging - genetics Aging, Premature - genetics Alzheimer's disease Birth weight Blood Chromosomes DNA methylation DNA Methylation - genetics Down syndrome Down Syndrome - genetics Down's syndrome Endocrine system Epigenesis, Genetic Epigenetics Epigenomics GATA-1 protein Gestational age Humans Immunosenescence Infant, Newborn Leukemia Medical screening Mutation Myelopoiesis Neonates Neurodegenerative diseases Standard deviation Variables
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