ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis

The role of autophagy in cancer is complex. Both tumor-promoting and tumor-suppressive effects are reported, with tumor type, stage and specific genetic lesions dictating the role. This calls for analysis in models that best recapitulate each tumor type, from initiation to metastatic disease, to spe...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-07, Vol.119 (28), p.e2113465119
Hauptverfasser:	Long, Jaclyn S, Kania, Elżbieta, McEwan, David G, Barthet, Valentin J A, Brucoli, Martina, Ladds, Marcus J G W, Nössing, Christoph, Ryan, Kevin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adenocarcinoma Animals Autophagy Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Biological Sciences Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - secondary Cell Line, Tumor Ectopic expression Embryos Hemizygosity Invasiveness Metastases Metastasis Mice Mutants Mutation Neoplasm Invasiveness Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Proto-Oncogene Proteins p21(ras) - genetics Succinates - metabolism Succinates - pharmacology Tumors
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