An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc-initiated retinoblastoma

Most retinoblastomas develop from maturing cone precursors in response to biallelic loss and are dependent on cone maturation-related signaling. Additionally, ∼2% lack mutations but have amplification ( ), N-Myc protein overexpression, and more rapid and invasive growth, yet the retinoblastoma cell...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-07, Vol.119 (28), p.e2200721119
Hauptverfasser:	Singh, Hardeep P, Shayler, Dominic W H, Fernandez, G Esteban, Thornton, Matthew E, Craft, Cheryl Mae, Grubbs, Brendan H, Cobrinik, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrestin Biological Sciences Cancer Carcinogenesis - genetics Cell Cycle Cell lineage Cell proliferation Cell signaling Cyclin D2 Deregulation Humans INK4a protein Invasiveness Markers Mutation Myc protein N-Myc protein N-Myc Proto-Oncogene Protein - genetics N-Myc Proto-Oncogene Protein - metabolism p16 Protein Phosphorylation Precursors Progenitor cells Retina Retinal cells Retinal Cone Photoreceptor Cells - metabolism Retinal Cone Photoreceptor Cells - pathology Retinal Neoplasms - metabolism Retinal Neoplasms - pathology Retinoblastoma Retinoblastoma - metabolism Retinoblastoma - pathology Signaling Sox9 protein Stem cells Tumorigenesis Tumors Xenografts Xenotransplantation
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