Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics

Mendelian randomization (MR) is a valuable tool for inferring causal relationships among a wide range of traits using summary statistics from genome-wide association studies (GWASs). Existing summary-level MR methods often rely on strong assumptions, resulting in many false-positive findings. To rel...

Ausführliche Beschreibung