The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis

Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of hospitalizations and hundreds of deaths within the United States in recent years. There is no effective antiviral therapy for hepatitis A, and many aspects of the hepatitis A virus (HAV) replication cycle remain...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-07, Vol.119 (28), p.1-9
Hauptverfasser:	Li, You, Misumi, Ichiro, Shiota, Tomoyuki, Sun, Lu, Lenarcic, Erik M., Kim, Hyejeong, Shirasaki, Takayoshi, Hertel-Wulff, Adriana, Tibbs, Taylor, Mitchell, Joseph E., McKnight, Kevin L., Cameron, Craig E., Moorman, Nathaniel J., McGivern, David R., Cullen, John M., Whitmire, Jason K., Lemon, Stanley M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animals Antiviral activity Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Apoptosis Biological Sciences Chromosomal Proteins, Non-Histone - metabolism Crosslinking DNA-Directed DNA Polymerase - metabolism Genomes Hepatitis Hepatitis A Hepatitis A - drug therapy Hepatitis A - metabolism Hepatitis A - virology Hepatitis A virus - drug effects Hepatitis A virus - genetics Hepatitis A virus - physiology Humans Immunoprecipitation Inflammation Intrinsically Disordered Proteins - metabolism Mice Mice, Mutant Strains Oral administration Polyadenine Polyadenylation Receptor, Interferon alpha-beta - genetics Replication RNA Nucleotidyltransferases - metabolism RNA viruses RNA, Viral - biosynthesis RNA, Viral - genetics Synthesis Transcription Translation Uridine Virus Replication - drug effects Zinc finger proteins
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