MALAT1 rs619586 A/G polymorphisms are associated with decreased risk of lung cancer
Lung cancer is the leading cause of cancer-associated mortality worldwide. Genetic factors are reported to play important roles in lung carcinogenesis. To evaluate genetic susceptibility, we conducted a hospital-based case-control study on the effects of functional single nucleotide polymorphisms (S...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-03, Vol.100 (12), p.e23716-e23716 |
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| creator | Chen, Ming Cai, Deng Gu, Haiyong Yang, Jun Fan, Liming |
| description | Lung cancer is the leading cause of cancer-associated mortality worldwide. Genetic factors are reported to play important roles in lung carcinogenesis. To evaluate genetic susceptibility, we conducted a hospital-based case-control study on the effects of functional single nucleotide polymorphisms (SNPs) in long non-coding RNAs (lncRNAs) and microRNAs on lung cancer development. A total of 917 lung cancer cases and 925 control subjects were recruited. The MALAT1 rs619586 A/G genotype frequencies between patient and control groups were significantly different (P G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. Our collective data indicated that MALAT1 rs619586 A/G SNPs significantly reduced the risk of lung cancer. Large-scale studies on different ethnic populations and tissue-specific biological characterization are required to validate the current findings. |
| doi_str_mv | 10.1097/MD.0000000000023716 |
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Genetic factors are reported to play important roles in lung carcinogenesis. To evaluate genetic susceptibility, we conducted a hospital-based case-control study on the effects of functional single nucleotide polymorphisms (SNPs) in long non-coding RNAs (lncRNAs) and microRNAs on lung cancer development. A total of 917 lung cancer cases and 925 control subjects were recruited. The MALAT1 rs619586 A/G genotype frequencies between patient and control groups were significantly different (P < .001), specifically, 83.85% vs 75.88% (AA), 15.60% vs 21.79% (AG), and 0.55% vs 2.32% (GG). When the homozygous genotype MALAT1 rs619586 AA was used as the reference group, AG (AG vs AA: adjusted odds ratio [OR] 0.65, 95% confidential interval [CI] 0.51-0.83, P = .001) and GG genotypes were associated with significantly decreased risk of lung cancer (GG vs AA: adjusted OR 0.22, 95% CI 0.08-0.59, P = .003). In the dominant model, MALAT1 rs619586 AG/GG variants were also associated with a significantly decreased risk of lung cancer (adjusted OR 0.61, 95% CI 0.48-0.78, P < .001). In the recessive model, when MALAT1 rs619586 AA/AG genotypes were used as the reference group, the GG homozygous genotype was also associated with significantly decreased risk for lung cancer (adjusted OR 0.24, 95% CI 0.09-0.64, P = .004). Hsa-miR-34b/c rs4938723 T > C, pri-miR-124-1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. Our collective data indicated that MALAT1 rs619586 A/G SNPs significantly reduced the risk of lung cancer. Large-scale studies on different ethnic populations and tissue-specific biological characterization are required to validate the current findings.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000023716</identifier><identifier>PMID: 33761627</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Aged ; Asian People - genetics ; Case-Control Studies ; Female ; Genotyping Techniques ; Humans ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Male ; MicroRNAs - genetics ; Middle Aged ; Observational Study ; Polymorphism, Single Nucleotide ; Protective Factors ; RNA, Long Noncoding - genetics</subject><ispartof>Medicine (Baltimore), 2021-03, Vol.100 (12), p.e23716-e23716</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4503-5182befbf914b45177e6c5dbe055e2440e157e126f39b3003cdcd70e288d6c7d3</citedby><cites>FETCH-LOGICAL-c4503-5182befbf914b45177e6c5dbe055e2440e157e126f39b3003cdcd70e288d6c7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281991/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281991/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33761627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Cai, Deng</creatorcontrib><creatorcontrib>Gu, Haiyong</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Fan, Liming</creatorcontrib><title>MALAT1 rs619586 A/G polymorphisms are associated with decreased risk of lung cancer</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Lung cancer is the leading cause of cancer-associated mortality worldwide. Genetic factors are reported to play important roles in lung carcinogenesis. To evaluate genetic susceptibility, we conducted a hospital-based case-control study on the effects of functional single nucleotide polymorphisms (SNPs) in long non-coding RNAs (lncRNAs) and microRNAs on lung cancer development. A total of 917 lung cancer cases and 925 control subjects were recruited. The MALAT1 rs619586 A/G genotype frequencies between patient and control groups were significantly different (P < .001), specifically, 83.85% vs 75.88% (AA), 15.60% vs 21.79% (AG), and 0.55% vs 2.32% (GG). When the homozygous genotype MALAT1 rs619586 AA was used as the reference group, AG (AG vs AA: adjusted odds ratio [OR] 0.65, 95% confidential interval [CI] 0.51-0.83, P = .001) and GG genotypes were associated with significantly decreased risk of lung cancer (GG vs AA: adjusted OR 0.22, 95% CI 0.08-0.59, P = .003). In the dominant model, MALAT1 rs619586 AG/GG variants were also associated with a significantly decreased risk of lung cancer (adjusted OR 0.61, 95% CI 0.48-0.78, P < .001). In the recessive model, when MALAT1 rs619586 AA/AG genotypes were used as the reference group, the GG homozygous genotype was also associated with significantly decreased risk for lung cancer (adjusted OR 0.24, 95% CI 0.09-0.64, P = .004). Hsa-miR-34b/c rs4938723 T > C, pri-miR-124-1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. Our collective data indicated that MALAT1 rs619586 A/G SNPs significantly reduced the risk of lung cancer. Large-scale studies on different ethnic populations and tissue-specific biological characterization are required to validate the current findings.</description><subject>Aged</subject><subject>Asian People - genetics</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genotyping Techniques</subject><subject>Humans</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Protective Factors</subject><subject>RNA, Long Noncoding - genetics</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtO6zAQhi0EgnJ5AqQjv0DA42u8OVIFh4vUig2sLceZkEDaVHZKxe6seUyehEC5z2Y0_8z_jfQTcgjsCJg1x9PTI_ZVXBjQG2QESuhMWS03yWhQVWaskTtkN6U7xkAYLrfJjhBGg-ZmRG6m48n4GmhMGqzK9fP_p_HxOV107eOsi4u6SbNEfUTqU-pC43ss6arpa1piiOjTMMYm3dOuou1yfkuDnweM-2Sr8m3Cg_e-R27O_l2fXGSTq_PLk_EkC1IxkSnIeYFVUVmQhVRgDOqgygKZUsilZAjKIHBdCVsIxkQoQ2kY8jwvdTCl2CN_19zFsphhGXDeR9-6RWxmPj66zjfu52be1O62e3CW52AtDACxBoTYpRSx-vQCc68pu-mp-53y4Prz_e2n5yPW4UCuD1Zd22NM9-1yhdHV6Nu-fuMpY3nGGQcmuGbZqyTEC3ZGiAU</recordid><startdate>20210326</startdate><enddate>20210326</enddate><creator>Chen, Ming</creator><creator>Cai, Deng</creator><creator>Gu, Haiyong</creator><creator>Yang, Jun</creator><creator>Fan, Liming</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20210326</creationdate><title>MALAT1 rs619586 A/G polymorphisms are associated with decreased risk of lung cancer</title><author>Chen, Ming ; Cai, Deng ; Gu, Haiyong ; Yang, Jun ; Fan, Liming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4503-5182befbf914b45177e6c5dbe055e2440e157e126f39b3003cdcd70e288d6c7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Asian People - genetics</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genotyping Techniques</topic><topic>Humans</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Protective Factors</topic><topic>RNA, Long Noncoding - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Cai, Deng</creatorcontrib><creatorcontrib>Gu, Haiyong</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Fan, Liming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ming</au><au>Cai, Deng</au><au>Gu, Haiyong</au><au>Yang, Jun</au><au>Fan, Liming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MALAT1 rs619586 A/G polymorphisms are associated with decreased risk of lung cancer</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-03-26</date><risdate>2021</risdate><volume>100</volume><issue>12</issue><spage>e23716</spage><epage>e23716</epage><pages>e23716-e23716</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Lung cancer is the leading cause of cancer-associated mortality worldwide. Genetic factors are reported to play important roles in lung carcinogenesis. To evaluate genetic susceptibility, we conducted a hospital-based case-control study on the effects of functional single nucleotide polymorphisms (SNPs) in long non-coding RNAs (lncRNAs) and microRNAs on lung cancer development. A total of 917 lung cancer cases and 925 control subjects were recruited. The MALAT1 rs619586 A/G genotype frequencies between patient and control groups were significantly different (P < .001), specifically, 83.85% vs 75.88% (AA), 15.60% vs 21.79% (AG), and 0.55% vs 2.32% (GG). When the homozygous genotype MALAT1 rs619586 AA was used as the reference group, AG (AG vs AA: adjusted odds ratio [OR] 0.65, 95% confidential interval [CI] 0.51-0.83, P = .001) and GG genotypes were associated with significantly decreased risk of lung cancer (GG vs AA: adjusted OR 0.22, 95% CI 0.08-0.59, P = .003). In the dominant model, MALAT1 rs619586 AG/GG variants were also associated with a significantly decreased risk of lung cancer (adjusted OR 0.61, 95% CI 0.48-0.78, P < .001). In the recessive model, when MALAT1 rs619586 AA/AG genotypes were used as the reference group, the GG homozygous genotype was also associated with significantly decreased risk for lung cancer (adjusted OR 0.24, 95% CI 0.09-0.64, P = .004). Hsa-miR-34b/c rs4938723 T > C, pri-miR-124-1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. Our collective data indicated that MALAT1 rs619586 A/G SNPs significantly reduced the risk of lung cancer. Large-scale studies on different ethnic populations and tissue-specific biological characterization are required to validate the current findings.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33761627</pmid><doi>10.1097/MD.0000000000023716</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Asian People - genetics Case-Control Studies Female Genotyping Techniques Humans Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male MicroRNAs - genetics Middle Aged Observational Study Polymorphism, Single Nucleotide Protective Factors RNA, Long Noncoding - genetics |
| title | MALAT1 rs619586 A/G polymorphisms are associated with decreased risk of lung cancer |
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