Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity

Although chimeric antigen receptor T (CART)-cell therapy has been successful in treating certain hematologic malignancies, wider adoption of CART-cell therapy is limited because of minimal activity in solid tumors and development of life-threatening toxicities, including cytokine release syndrome (C...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer immunology research 2021-09, Vol.9 (9), p.1035-1046
Hauptverfasser:	Sakemura, Reona, Bansal, Aditya, Siegler, Elizabeth L, Hefazi, Mehrdad, Yang, Nan, Khadka, Roman H, Newsom, Alysha N, Hansen, Michael J, Cox, Michelle J, Manriquez Roman, Claudia, Schick, Kendall J, Can, Ismail, Tapper, Erin E, Nevala, Wendy K, Adada, Mohamad M, Bezerra, Evandro D, Kankeu Fonkoua, Lionel Aurelien, Horvei, Paulina, Ruff, Michael W, Parikh, Sameer A, Pandey, Mukesh K, DeGrado, Timothy R, Suksanpaisan, Lukkana, Kay, Neil E, Peng, Kah-Whye, Russell, Stephen J, Kenderian, Saad S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD19 Disease Models, Animal Female Humans K562 Cells Male Neoplasms - diagnostic imaging Neoplasms - immunology Positron-Emission Tomography - methods Receptors, Antigen, T-Cell - metabolism Receptors, Chimeric Antigen - metabolism Symporters - analysis Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!