OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells
Background This study aimed to analyze the expression of 8‐oxoguanine DNA glycosylase (OGG1) in patients with hepatocellular carcinoma (HCC) and its effect on prognosis by bioinformatics techniques and to determine its possible carcinogenic mechanism through data mining. Methods The difference in OG...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical laboratory analysis 2022-07, Vol.36 (7), p.e24561-n/a |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 7 |
| container_start_page | e24561 |
| container_title | Journal of clinical laboratory analysis |
| container_volume | 36 |
| creator | Zhang, He Jiang, Peng‐jun Lv, Meng‐yuan Zhao, Yan‐hua Cui, Ju Chen, Jie |
| description | Background
This study aimed to analyze the expression of 8‐oxoguanine DNA glycosylase (OGG1) in patients with hepatocellular carcinoma (HCC) and its effect on prognosis by bioinformatics techniques and to determine its possible carcinogenic mechanism through data mining.
Methods
The difference in OGG1 expression between healthy people and HCC patients was searched and analyzed by TCGA and GEO databases, and the effect of OGG1 on prognosis was judged by survival analysis. Meanwhile, the possible molecular mechanism of OGG1 in the tumorigenesis and development of HCC was explored by GO analysis, KEGG analysis, immune infiltration analysis, protein–protein interaction network, promoter methylation analysis, and so forth. Quantitative polymerase chain reaction (qPCR) was used to examine the gene expression in 36 pairs of HCC tissues and adjacent tissues.
Results
The expression of OGG1 in HCC patients was higher than that in healthy people, and the overexpression of OGG1 might stimulate cell proliferation by increasing the activity of cell cycle‐related proteins.
Conclusion
The alteration of OGG1 was significantly correlated with the tumorigenesis and development of HCC. OGG1 is expected to be a new biomarker for evaluating the prognosis of HCC and a new target for the treatment of HCC.
Figure 1 Expression of OGG1 in HCC, (A) expression of OGG1 in nucleoplasma, (B, C) OGG1 expression in healthy liver tissues, (D, E, F) OGG1 expression in liver tissues of HCC patients (G) expression of OGG1 in HCC based on sample type (H) nodal metastasis status (I) TP53 mutation status (J) age (K) gender (L) race (M) stage (N) grade (O) histological subtype. |
| doi_str_mv | 10.1002/jcla.24561 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9279955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2688887307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4251-6262f8970d249a65ca6e02f64dbb36ebbe2ace8fd1a1efa492ed1beeab985d043</originalsourceid><addsrcrecordid>eNp9kc1uEzEUhS1ERUNhwxNYYoOQptieP3uDFAUIoIhuYG3dse8kjmbsYM-0zY5HYM3j8STMNBVSWeCNF-c7x_f6EPKCs0vOmHizNx1ciqKs-COy4EzJTEhRPiYLJmWdScbzc_I0pT1jTCpePSHneVmLvBD5gvy6Wq85NcEP0TXjgIkOge7wAEMw2HVjB5EaiMb50ANtjvQQQx8G57d01qk5mg5___gZsYMB7SwP6DzF20PElFzwFLyl6Hfgzex692VJw62zMLhrpBZ62CKN04Mu0sk3jH2Id9HpGTlroUv4_P6-IN8-vP-6-phtrtafVstNZgpR8qwSlWilqpkVhYKqNFAhE21V2KbJK2waFGBQtpYDxxYKJdDyBhEaJUvLivyCvD3lHsamR2tw-gvo9CG6HuJRB3D6oeLdTm_DtVaiVqosp4BX9wExfB8xDbp3aV4BPIYxaVHVss4VF3xCX_6D7sMY_bTeRMnp1DmrJ-r1iTIxpBSx_TsMZ3quXM-V67vKJ5if4BvX4fE_pP682ixPnj-EgLKn</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2688887307</pqid></control><display><type>article</type><title>OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells</title><source>Wiley Online Library - AutoHoldings Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Zhang, He ; Jiang, Peng‐jun ; Lv, Meng‐yuan ; Zhao, Yan‐hua ; Cui, Ju ; Chen, Jie</creator><creatorcontrib>Zhang, He ; Jiang, Peng‐jun ; Lv, Meng‐yuan ; Zhao, Yan‐hua ; Cui, Ju ; Chen, Jie</creatorcontrib><description>Background
This study aimed to analyze the expression of 8‐oxoguanine DNA glycosylase (OGG1) in patients with hepatocellular carcinoma (HCC) and its effect on prognosis by bioinformatics techniques and to determine its possible carcinogenic mechanism through data mining.
Methods
The difference in OGG1 expression between healthy people and HCC patients was searched and analyzed by TCGA and GEO databases, and the effect of OGG1 on prognosis was judged by survival analysis. Meanwhile, the possible molecular mechanism of OGG1 in the tumorigenesis and development of HCC was explored by GO analysis, KEGG analysis, immune infiltration analysis, protein–protein interaction network, promoter methylation analysis, and so forth. Quantitative polymerase chain reaction (qPCR) was used to examine the gene expression in 36 pairs of HCC tissues and adjacent tissues.
Results
The expression of OGG1 in HCC patients was higher than that in healthy people, and the overexpression of OGG1 might stimulate cell proliferation by increasing the activity of cell cycle‐related proteins.
Conclusion
The alteration of OGG1 was significantly correlated with the tumorigenesis and development of HCC. OGG1 is expected to be a new biomarker for evaluating the prognosis of HCC and a new target for the treatment of HCC.
Figure 1 Expression of OGG1 in HCC, (A) expression of OGG1 in nucleoplasma, (B, C) OGG1 expression in healthy liver tissues, (D, E, F) OGG1 expression in liver tissues of HCC patients (G) expression of OGG1 in HCC based on sample type (H) nodal metastasis status (I) TP53 mutation status (J) age (K) gender (L) race (M) stage (N) grade (O) histological subtype.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.24561</identifier><identifier>PMID: 35723423</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>8-Hydroxyguanine ; base excision repair ; Bioinformatics ; Cell cycle ; cell cycle‐related proteins ; Cell proliferation ; DNA damage ; DNA glycosylase ; DNA methylation ; DNA repair ; Epigenetics ; Gene expression ; Hepatitis ; Hepatocellular carcinoma ; Liver cancer ; Medical prognosis ; Metastases ; Metastasis ; Mutation ; OGG1 ; OGG1 protein ; Patients ; Prognosis ; Proteins ; Software ; Statistical analysis ; Tumor cells ; Tumorigenesis ; Tumors</subject><ispartof>Journal of clinical laboratory analysis, 2022-07, Vol.36 (7), p.e24561-n/a</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4251-6262f8970d249a65ca6e02f64dbb36ebbe2ace8fd1a1efa492ed1beeab985d043</citedby><cites>FETCH-LOGICAL-c4251-6262f8970d249a65ca6e02f64dbb36ebbe2ace8fd1a1efa492ed1beeab985d043</cites><orcidid>0000-0001-6312-4770</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279955/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279955/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids></links><search><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Jiang, Peng‐jun</creatorcontrib><creatorcontrib>Lv, Meng‐yuan</creatorcontrib><creatorcontrib>Zhao, Yan‐hua</creatorcontrib><creatorcontrib>Cui, Ju</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><title>OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells</title><title>Journal of clinical laboratory analysis</title><description>Background
This study aimed to analyze the expression of 8‐oxoguanine DNA glycosylase (OGG1) in patients with hepatocellular carcinoma (HCC) and its effect on prognosis by bioinformatics techniques and to determine its possible carcinogenic mechanism through data mining.
Methods
The difference in OGG1 expression between healthy people and HCC patients was searched and analyzed by TCGA and GEO databases, and the effect of OGG1 on prognosis was judged by survival analysis. Meanwhile, the possible molecular mechanism of OGG1 in the tumorigenesis and development of HCC was explored by GO analysis, KEGG analysis, immune infiltration analysis, protein–protein interaction network, promoter methylation analysis, and so forth. Quantitative polymerase chain reaction (qPCR) was used to examine the gene expression in 36 pairs of HCC tissues and adjacent tissues.
Results
The expression of OGG1 in HCC patients was higher than that in healthy people, and the overexpression of OGG1 might stimulate cell proliferation by increasing the activity of cell cycle‐related proteins.
Conclusion
The alteration of OGG1 was significantly correlated with the tumorigenesis and development of HCC. OGG1 is expected to be a new biomarker for evaluating the prognosis of HCC and a new target for the treatment of HCC.
Figure 1 Expression of OGG1 in HCC, (A) expression of OGG1 in nucleoplasma, (B, C) OGG1 expression in healthy liver tissues, (D, E, F) OGG1 expression in liver tissues of HCC patients (G) expression of OGG1 in HCC based on sample type (H) nodal metastasis status (I) TP53 mutation status (J) age (K) gender (L) race (M) stage (N) grade (O) histological subtype.</description><subject>8-Hydroxyguanine</subject><subject>base excision repair</subject><subject>Bioinformatics</subject><subject>Cell cycle</subject><subject>cell cycle‐related proteins</subject><subject>Cell proliferation</subject><subject>DNA damage</subject><subject>DNA glycosylase</subject><subject>DNA methylation</subject><subject>DNA repair</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Hepatitis</subject><subject>Hepatocellular carcinoma</subject><subject>Liver cancer</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>OGG1</subject><subject>OGG1 protein</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Tumor cells</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1uEzEUhS1ERUNhwxNYYoOQptieP3uDFAUIoIhuYG3dse8kjmbsYM-0zY5HYM3j8STMNBVSWeCNF-c7x_f6EPKCs0vOmHizNx1ciqKs-COy4EzJTEhRPiYLJmWdScbzc_I0pT1jTCpePSHneVmLvBD5gvy6Wq85NcEP0TXjgIkOge7wAEMw2HVjB5EaiMb50ANtjvQQQx8G57d01qk5mg5___gZsYMB7SwP6DzF20PElFzwFLyl6Hfgzex692VJw62zMLhrpBZ62CKN04Mu0sk3jH2Id9HpGTlroUv4_P6-IN8-vP-6-phtrtafVstNZgpR8qwSlWilqpkVhYKqNFAhE21V2KbJK2waFGBQtpYDxxYKJdDyBhEaJUvLivyCvD3lHsamR2tw-gvo9CG6HuJRB3D6oeLdTm_DtVaiVqosp4BX9wExfB8xDbp3aV4BPIYxaVHVss4VF3xCX_6D7sMY_bTeRMnp1DmrJ-r1iTIxpBSx_TsMZ3quXM-V67vKJ5if4BvX4fE_pP682ixPnj-EgLKn</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Zhang, He</creator><creator>Jiang, Peng‐jun</creator><creator>Lv, Meng‐yuan</creator><creator>Zhao, Yan‐hua</creator><creator>Cui, Ju</creator><creator>Chen, Jie</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6312-4770</orcidid></search><sort><creationdate>202207</creationdate><title>OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells</title><author>Zhang, He ; Jiang, Peng‐jun ; Lv, Meng‐yuan ; Zhao, Yan‐hua ; Cui, Ju ; Chen, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4251-6262f8970d249a65ca6e02f64dbb36ebbe2ace8fd1a1efa492ed1beeab985d043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>8-Hydroxyguanine</topic><topic>base excision repair</topic><topic>Bioinformatics</topic><topic>Cell cycle</topic><topic>cell cycle‐related proteins</topic><topic>Cell proliferation</topic><topic>DNA damage</topic><topic>DNA glycosylase</topic><topic>DNA methylation</topic><topic>DNA repair</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>Hepatitis</topic><topic>Hepatocellular carcinoma</topic><topic>Liver cancer</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>OGG1</topic><topic>OGG1 protein</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Tumor cells</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Jiang, Peng‐jun</creatorcontrib><creatorcontrib>Lv, Meng‐yuan</creatorcontrib><creatorcontrib>Zhao, Yan‐hua</creatorcontrib><creatorcontrib>Cui, Ju</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, He</au><au>Jiang, Peng‐jun</au><au>Lv, Meng‐yuan</au><au>Zhao, Yan‐hua</au><au>Cui, Ju</au><au>Chen, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><date>2022-07</date><risdate>2022</risdate><volume>36</volume><issue>7</issue><spage>e24561</spage><epage>n/a</epage><pages>e24561-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background
This study aimed to analyze the expression of 8‐oxoguanine DNA glycosylase (OGG1) in patients with hepatocellular carcinoma (HCC) and its effect on prognosis by bioinformatics techniques and to determine its possible carcinogenic mechanism through data mining.
Methods
The difference in OGG1 expression between healthy people and HCC patients was searched and analyzed by TCGA and GEO databases, and the effect of OGG1 on prognosis was judged by survival analysis. Meanwhile, the possible molecular mechanism of OGG1 in the tumorigenesis and development of HCC was explored by GO analysis, KEGG analysis, immune infiltration analysis, protein–protein interaction network, promoter methylation analysis, and so forth. Quantitative polymerase chain reaction (qPCR) was used to examine the gene expression in 36 pairs of HCC tissues and adjacent tissues.
Results
The expression of OGG1 in HCC patients was higher than that in healthy people, and the overexpression of OGG1 might stimulate cell proliferation by increasing the activity of cell cycle‐related proteins.
Conclusion
The alteration of OGG1 was significantly correlated with the tumorigenesis and development of HCC. OGG1 is expected to be a new biomarker for evaluating the prognosis of HCC and a new target for the treatment of HCC.
Figure 1 Expression of OGG1 in HCC, (A) expression of OGG1 in nucleoplasma, (B, C) OGG1 expression in healthy liver tissues, (D, E, F) OGG1 expression in liver tissues of HCC patients (G) expression of OGG1 in HCC based on sample type (H) nodal metastasis status (I) TP53 mutation status (J) age (K) gender (L) race (M) stage (N) grade (O) histological subtype.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>35723423</pmid><doi>10.1002/jcla.24561</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6312-4770</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-8013 |
| ispartof | Journal of clinical laboratory analysis, 2022-07, Vol.36 (7), p.e24561-n/a |
| issn | 0887-8013 1098-2825 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9279955 |
| source | Wiley Online Library - AutoHoldings Journals; DOAJ Directory of Open Access Journals; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 8-Hydroxyguanine base excision repair Bioinformatics Cell cycle cell cycle‐related proteins Cell proliferation DNA damage DNA glycosylase DNA methylation DNA repair Epigenetics Gene expression Hepatitis Hepatocellular carcinoma Liver cancer Medical prognosis Metastases Metastasis Mutation OGG1 OGG1 protein Patients Prognosis Proteins Software Statistical analysis Tumor cells Tumorigenesis Tumors |
| title | OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T07%3A51%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=OGG1%20contributes%20to%20hepatocellular%20carcinoma%20by%20promoting%20cell%20cycle%E2%80%90related%20protein%20expression%20and%20enhancing%20DNA%20oxidative%20damage%20repair%20in%20tumor%20cells&rft.jtitle=Journal%20of%20clinical%20laboratory%20analysis&rft.au=Zhang,%20He&rft.date=2022-07&rft.volume=36&rft.issue=7&rft.spage=e24561&rft.epage=n/a&rft.pages=e24561-n/a&rft.issn=0887-8013&rft.eissn=1098-2825&rft_id=info:doi/10.1002/jcla.24561&rft_dat=%3Cproquest_pubme%3E2688887307%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2688887307&rft_id=info:pmid/35723423&rfr_iscdi=true |