Superficial Retinal Vessel Density and Foveal Avascular Zone in Myopic Anisometropia: An OCTA-Based Study in Young Chinese Children
This retrospective study investigated superficial retinal vessel density (SRVLD) and foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in children with myopic anisometropia. We included 84 eyes of 42 individuals with myopic anisometropia and no posterior segment...
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| description | This retrospective study investigated superficial retinal vessel density (SRVLD) and foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in children with myopic anisometropia. We included 84 eyes of 42 individuals with myopic anisometropia and no posterior segment abnormalities. All eyes underwent OCTA. Individual SRVLD and FAZ area were measured on OCTA. Using a paired t-test, we compared the interocular difference between the fellow eyes for all the measurements. SRVLD was significantly higher in the relatively more myopic eyes than in the fellow eyes in the whole population and in patients with an interocular difference of >1.5 D (p=003 and 0.01, respectively). In patients with an interocular difference of ≤1.5 D in spherical equivalent refraction, only the nasal sector showed higher SRVLD in the less myopic eyes. SRVLD in the whole image and parafoveal sector was significantly lower in the dominant eye (paired t-test, p=003 and 0.03, respectively), while other locations showed no difference. The area, perimeter, and circularity index in FAZ parameters showed no difference. SRVLD showed no significant differences between the two types of eyes, with an interocular difference of ≤1.5 D but increased in the relatively more myopic eyes than in the fellow eyes in children with myopic anisometropia, with an interocular difference of >1.5 D. Increasing SRVLD may show a compensatory increase to maintain retinal function and thus maintain normal visual function in the relatively more myopic fellow eyes. As the study to use patients as self-control with OCTA analysis in both eyes, this study provides some reference value for further interpretation of the pathogenesis of anisometropia. |
| doi_str_mv | 10.1155/2022/1229009 |
| format | Article |
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We included 84 eyes of 42 individuals with myopic anisometropia and no posterior segment abnormalities. All eyes underwent OCTA. Individual SRVLD and FAZ area were measured on OCTA. Using a paired t-test, we compared the interocular difference between the fellow eyes for all the measurements. SRVLD was significantly higher in the relatively more myopic eyes than in the fellow eyes in the whole population and in patients with an interocular difference of >1.5 D (p=003 and 0.01, respectively). In patients with an interocular difference of ≤1.5 D in spherical equivalent refraction, only the nasal sector showed higher SRVLD in the less myopic eyes. SRVLD in the whole image and parafoveal sector was significantly lower in the dominant eye (paired t-test, p=003 and 0.03, respectively), while other locations showed no difference. The area, perimeter, and circularity index in FAZ parameters showed no difference. SRVLD showed no significant differences between the two types of eyes, with an interocular difference of ≤1.5 D but increased in the relatively more myopic eyes than in the fellow eyes in children with myopic anisometropia, with an interocular difference of >1.5 D. Increasing SRVLD may show a compensatory increase to maintain retinal function and thus maintain normal visual function in the relatively more myopic fellow eyes. As the study to use patients as self-control with OCTA analysis in both eyes, this study provides some reference value for further interpretation of the pathogenesis of anisometropia.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/1229009</identifier><identifier>PMID: 35845945</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Abnormalities ; Age ; Angiography ; Asymmetry ; Biomedical research ; Blood vessels ; Children ; Density ; Eye ; Myopia ; Pathogenesis ; Retina ; Visual perception</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.1229009-1229009</ispartof><rights>Copyright © 2022 Fen Xiong et al.</rights><rights>Copyright © 2022 Fen Xiong et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Fen Xiong et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c382t-5df1d30a32a8254e11443c54d0b062a3545e4ac546852b53d1244ac828e3c1923</cites><orcidid>0000-0003-3468-452X ; 0000-0001-6004-8709 ; 0000-0003-1955-6570</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279070/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279070/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4023,27922,27923,27924,53790,53792</link.rule.ids></links><search><contributor>Marques, João P.</contributor><contributor>João P Marques</contributor><creatorcontrib>Xiong, Fen</creatorcontrib><creatorcontrib>Mao, Tian</creatorcontrib><creatorcontrib>Wang, Junchen</creatorcontrib><creatorcontrib>Yi, Jinglin</creatorcontrib><creatorcontrib>Hu, Yang</creatorcontrib><creatorcontrib>Liao, Hongfei</creatorcontrib><title>Superficial Retinal Vessel Density and Foveal Avascular Zone in Myopic Anisometropia: An OCTA-Based Study in Young Chinese Children</title><title>BioMed research international</title><description>This retrospective study investigated superficial retinal vessel density (SRVLD) and foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in children with myopic anisometropia. We included 84 eyes of 42 individuals with myopic anisometropia and no posterior segment abnormalities. All eyes underwent OCTA. Individual SRVLD and FAZ area were measured on OCTA. Using a paired t-test, we compared the interocular difference between the fellow eyes for all the measurements. SRVLD was significantly higher in the relatively more myopic eyes than in the fellow eyes in the whole population and in patients with an interocular difference of >1.5 D (p=003 and 0.01, respectively). In patients with an interocular difference of ≤1.5 D in spherical equivalent refraction, only the nasal sector showed higher SRVLD in the less myopic eyes. SRVLD in the whole image and parafoveal sector was significantly lower in the dominant eye (paired t-test, p=003 and 0.03, respectively), while other locations showed no difference. The area, perimeter, and circularity index in FAZ parameters showed no difference. 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international</jtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>1229009</spage><epage>1229009</epage><pages>1229009-1229009</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>This retrospective study investigated superficial retinal vessel density (SRVLD) and foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in children with myopic anisometropia. 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SRVLD showed no significant differences between the two types of eyes, with an interocular difference of ≤1.5 D but increased in the relatively more myopic eyes than in the fellow eyes in children with myopic anisometropia, with an interocular difference of >1.5 D. Increasing SRVLD may show a compensatory increase to maintain retinal function and thus maintain normal visual function in the relatively more myopic fellow eyes. As the study to use patients as self-control with OCTA analysis in both eyes, this study provides some reference value for further interpretation of the pathogenesis of anisometropia.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>35845945</pmid><doi>10.1155/2022/1229009</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3468-452X</orcidid><orcidid>https://orcid.org/0000-0001-6004-8709</orcidid><orcidid>https://orcid.org/0000-0003-1955-6570</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Age Angiography Asymmetry Biomedical research Blood vessels Children Density Eye Myopia Pathogenesis Retina Visual perception |
| title | Superficial Retinal Vessel Density and Foveal Avascular Zone in Myopic Anisometropia: An OCTA-Based Study in Young Chinese Children |
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