The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect

Aerobic glycolysis in cancer cells, also known as the ‘Warburg effect’, is driven by hyperactivity of lactate dehydrogenase A (LDHA). LDHA is thought to be a substrate-regulated enzyme, but it is unclear whether a dedicated intracellular protein also regulates its activity. Here, we identify the hum...

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Veröffentlicht in:	Nature structural & molecular biology 2021-08, Vol.28 (8), p.662-670
Hauptverfasser:	Woodford, Mark R., Baker-Williams, Alexander J., Sager, Rebecca A., Backe, Sarah J., Blanden, Adam R., Hashmi, Fiza, Kancherla, Priyanka, Gori, Alessandro, Loiselle, David R., Castelli, Matteo, Serapian, Stefano A., Colombo, Giorgio, Haystead, Timothy A., Jensen, Sandra M., Stetler-Stevenson, William G., Loh, Stewart N., Schmidt, Laura S., Linehan, W. Marston, Bah, Alaji, Bourboulia, Dimitra, Bratslavsky, Gennady, Mollapour, Mehdi
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 631/45/173 692/699/67/1244 82/58 82/80 96 96/1 Biochemistry Biological Microscopy Biomedical and Life Sciences Cancer Catalytic Domain - physiology Cell death Cell Line, Tumor Cell metabolism Cell Proliferation Dehydrogenase Dehydrogenases Development and progression Enzymatic activity Enzyme activity Enzymes Gene Expression Regulation, Neoplastic - genetics Genetic aspects Glycolysis Glycolysis - physiology Health aspects HEK293 Cells Homeostasis Humans Hyperactivity Inactivation Intracellular L-Lactate dehydrogenase Lactate dehydrogenase Lactate Dehydrogenase 5 - antagonists & inhibitors Lactate Dehydrogenase 5 - metabolism Lactic acid Life Sciences Membrane Biology Neoplasms - metabolism Oncology, Experimental Protein Structure Proto-Oncogene Proteins - metabolism Signal Transduction Substrates Tumor suppressor genes Tumor Suppressor Proteins - metabolism Tumors
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