Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort
Abstract Background Latinos are the largest minority group in the United States. We assessed cancer mortality by birthplace and generation status of Mexican Latinos in the Multiethnic Cohort. Methods We included 26 751 Latinos of Mexican origin and 6093 non-Latino Whites aged 45-74 years at cohort e...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2022-07, Vol.114 (7), p.959-968 |
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| creator | Chen, Hongjie Wu, Anna H Wang, Songren Bookstein, Arthur Le Marchand, Loïc Wilkens, Lynne R Haiman, Christopher A Cheng, Iona Monroe, Kristine R Setiawan, Veronica Wendy |
| description | Abstract
Background
Latinos are the largest minority group in the United States. We assessed cancer mortality by birthplace and generation status of Mexican Latinos in the Multiethnic Cohort.
Methods
We included 26 751 Latinos of Mexican origin and 6093 non-Latino Whites aged 45-74 years at cohort entry (1993-1996) from the California Multiethnic Cohort component. The Mexican Latinos comprised 42% first-generation Mexico-born immigrants, 42% second-generation (28% US-born with both parents Mexico-born and 14% US-born with 1 parent US-born and 1 parent Mexico-born), and 16% third-generation or more who were US-born with both parents US-born. Multivariable Cox models were used to calculate covariate adjusted hazard ratios and 95% confidence intervals for overall and site-specific cancer mortality by birthplace and generation status. All statistical tests were 2-sided.
Results
Cancer death rate was highest among the US-born with 1 parent US-born and 1 parent Mexico-born (age-adjusted rate = 471.0 per 100 000 person-years) and US-born with both parents US-born (age-adjusted rate = 469.0 per 100 000 person-years) groups. The US-born with both parents Mexico-born group had a 30% (hazard ratio = 1.30, 95% confidence interval = 1.18 to 1.44) higher risk of cancer death than the first-generation Mexico-born immigrants group, showing US birthplace was associated with an elevated cancer mortality. For cancer-specific mortality, US birthplace was positively associated with colorectal, liver and lung, and ovarian cancer (P values ranged from .04 to .005). Among US-born Mexican Latinos, generation status was not statistically significantly associated with overall cancer or site-specific cancer mortality.
Conclusions
Our findings suggest that US birthplace is a risk factor for cancer death in Mexican Americans. Identification of the contributing factors is important to curtail patterns of increasing cancer mortality in US-born Mexican Latinos. |
| doi_str_mv | 10.1093/jnci/djac078 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9275754</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jnci/djac078</oup_id><sourcerecordid>2649252414</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-2f6de5d662f361ffccac6cec90fe748942699b7c46d560ac0099e4eaa9c23cf3</originalsourceid><addsrcrecordid>eNp9kcGLEzEUh4Mobl29eZaABz04biaTZBoPwlp0FVoU7D2kb944KdOkm2Rk-9-b0rqoB9_lHd7Hx_vxI-R5zd7WTDdXWw_uqttaYO38AZnVQrGK10w-JDPGeFvN5624IE9S2rIymovH5KKRggkh2YwMC-sBI12FmO3o8oF-szlj9IluDvSDi3nYjxaQWt_RG_QYbXbB0-_Z5inR0NMV3jmwni7LwYf0jq4HpKtpzA7z4B3QRRiK_Cl51Nsx4bPzviTrTx_Xi8_V8uvNl8X1sgIhRK54rzqUnVK8b1Td9wAWFCBo1mMr5lpwpfWmBaE6qVgJzbRGgdZq4A30zSV5f9Lup80OO0Cfox3NPrqdjQcTrDN_X7wbzI_w02jeylaKInh9FsRwO2HKZucS4Dhaj2FKhiuhueSiPqIv_0G3YYq-pDPHLxVraiEL9eZEQQwpRezvn6mZOTZojg2ac4MFf_FngHv4d2UFeHUCwrT_v-oXJ9in5w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2699603145</pqid></control><display><type>article</type><title>Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Chen, Hongjie ; Wu, Anna H ; Wang, Songren ; Bookstein, Arthur ; Le Marchand, Loïc ; Wilkens, Lynne R ; Haiman, Christopher A ; Cheng, Iona ; Monroe, Kristine R ; Setiawan, Veronica Wendy</creator><creatorcontrib>Chen, Hongjie ; Wu, Anna H ; Wang, Songren ; Bookstein, Arthur ; Le Marchand, Loïc ; Wilkens, Lynne R ; Haiman, Christopher A ; Cheng, Iona ; Monroe, Kristine R ; Setiawan, Veronica Wendy</creatorcontrib><description>Abstract
Background
Latinos are the largest minority group in the United States. We assessed cancer mortality by birthplace and generation status of Mexican Latinos in the Multiethnic Cohort.
Methods
We included 26 751 Latinos of Mexican origin and 6093 non-Latino Whites aged 45-74 years at cohort entry (1993-1996) from the California Multiethnic Cohort component. The Mexican Latinos comprised 42% first-generation Mexico-born immigrants, 42% second-generation (28% US-born with both parents Mexico-born and 14% US-born with 1 parent US-born and 1 parent Mexico-born), and 16% third-generation or more who were US-born with both parents US-born. Multivariable Cox models were used to calculate covariate adjusted hazard ratios and 95% confidence intervals for overall and site-specific cancer mortality by birthplace and generation status. All statistical tests were 2-sided.
Results
Cancer death rate was highest among the US-born with 1 parent US-born and 1 parent Mexico-born (age-adjusted rate = 471.0 per 100 000 person-years) and US-born with both parents US-born (age-adjusted rate = 469.0 per 100 000 person-years) groups. The US-born with both parents Mexico-born group had a 30% (hazard ratio = 1.30, 95% confidence interval = 1.18 to 1.44) higher risk of cancer death than the first-generation Mexico-born immigrants group, showing US birthplace was associated with an elevated cancer mortality. For cancer-specific mortality, US birthplace was positively associated with colorectal, liver and lung, and ovarian cancer (P values ranged from .04 to .005). Among US-born Mexican Latinos, generation status was not statistically significantly associated with overall cancer or site-specific cancer mortality.
Conclusions
Our findings suggest that US birthplace is a risk factor for cancer death in Mexican Americans. Identification of the contributing factors is important to curtail patterns of increasing cancer mortality in US-born Mexican Latinos.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/djac078</identifier><identifier>PMID: 35404450</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Cancer ; Cohort Studies ; Death ; Editor's Choice ; Health hazards ; Health risks ; Hispanic Americans ; Hispanic or Latino ; Humans ; Immigrants ; Lung cancer ; Mexico - epidemiology ; Minority & ethnic groups ; Mortality ; Mortality patterns ; Neoplasms ; Ovarian cancer ; Parents & parenting ; Residence Characteristics ; Risk analysis ; Risk factors ; Statistical analysis ; Statistical tests ; United States - epidemiology</subject><ispartof>JNCI : Journal of the National Cancer Institute, 2022-07, Vol.114 (7), p.959-968</ispartof><rights>The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-2f6de5d662f361ffccac6cec90fe748942699b7c46d560ac0099e4eaa9c23cf3</citedby><cites>FETCH-LOGICAL-c444t-2f6de5d662f361ffccac6cec90fe748942699b7c46d560ac0099e4eaa9c23cf3</cites><orcidid>0000-0001-9239-5692 ; 0000-0002-3016-2081 ; 0000-0002-6438-108X ; 0000-0001-5013-980X ; 0000-0001-8218-0401</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35404450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hongjie</creatorcontrib><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Wang, Songren</creatorcontrib><creatorcontrib>Bookstein, Arthur</creatorcontrib><creatorcontrib>Le Marchand, Loïc</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Haiman, Christopher A</creatorcontrib><creatorcontrib>Cheng, Iona</creatorcontrib><creatorcontrib>Monroe, Kristine R</creatorcontrib><creatorcontrib>Setiawan, Veronica Wendy</creatorcontrib><title>Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>Abstract
Background
Latinos are the largest minority group in the United States. We assessed cancer mortality by birthplace and generation status of Mexican Latinos in the Multiethnic Cohort.
Methods
We included 26 751 Latinos of Mexican origin and 6093 non-Latino Whites aged 45-74 years at cohort entry (1993-1996) from the California Multiethnic Cohort component. The Mexican Latinos comprised 42% first-generation Mexico-born immigrants, 42% second-generation (28% US-born with both parents Mexico-born and 14% US-born with 1 parent US-born and 1 parent Mexico-born), and 16% third-generation or more who were US-born with both parents US-born. Multivariable Cox models were used to calculate covariate adjusted hazard ratios and 95% confidence intervals for overall and site-specific cancer mortality by birthplace and generation status. All statistical tests were 2-sided.
Results
Cancer death rate was highest among the US-born with 1 parent US-born and 1 parent Mexico-born (age-adjusted rate = 471.0 per 100 000 person-years) and US-born with both parents US-born (age-adjusted rate = 469.0 per 100 000 person-years) groups. The US-born with both parents Mexico-born group had a 30% (hazard ratio = 1.30, 95% confidence interval = 1.18 to 1.44) higher risk of cancer death than the first-generation Mexico-born immigrants group, showing US birthplace was associated with an elevated cancer mortality. For cancer-specific mortality, US birthplace was positively associated with colorectal, liver and lung, and ovarian cancer (P values ranged from .04 to .005). Among US-born Mexican Latinos, generation status was not statistically significantly associated with overall cancer or site-specific cancer mortality.
Conclusions
Our findings suggest that US birthplace is a risk factor for cancer death in Mexican Americans. Identification of the contributing factors is important to curtail patterns of increasing cancer mortality in US-born Mexican Latinos.</description><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Death</subject><subject>Editor's Choice</subject><subject>Health hazards</subject><subject>Health risks</subject><subject>Hispanic Americans</subject><subject>Hispanic or Latino</subject><subject>Humans</subject><subject>Immigrants</subject><subject>Lung cancer</subject><subject>Mexico - epidemiology</subject><subject>Minority & ethnic groups</subject><subject>Mortality</subject><subject>Mortality patterns</subject><subject>Neoplasms</subject><subject>Ovarian cancer</subject><subject>Parents & parenting</subject><subject>Residence Characteristics</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>United States - epidemiology</subject><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGLEzEUh4Mobl29eZaABz04biaTZBoPwlp0FVoU7D2kb944KdOkm2Rk-9-b0rqoB9_lHd7Hx_vxI-R5zd7WTDdXWw_uqttaYO38AZnVQrGK10w-JDPGeFvN5624IE9S2rIymovH5KKRggkh2YwMC-sBI12FmO3o8oF-szlj9IluDvSDi3nYjxaQWt_RG_QYbXbB0-_Z5inR0NMV3jmwni7LwYf0jq4HpKtpzA7z4B3QRRiK_Cl51Nsx4bPzviTrTx_Xi8_V8uvNl8X1sgIhRK54rzqUnVK8b1Td9wAWFCBo1mMr5lpwpfWmBaE6qVgJzbRGgdZq4A30zSV5f9Lup80OO0Cfox3NPrqdjQcTrDN_X7wbzI_w02jeylaKInh9FsRwO2HKZucS4Dhaj2FKhiuhueSiPqIv_0G3YYq-pDPHLxVraiEL9eZEQQwpRezvn6mZOTZojg2ac4MFf_FngHv4d2UFeHUCwrT_v-oXJ9in5w</recordid><startdate>20220711</startdate><enddate>20220711</enddate><creator>Chen, Hongjie</creator><creator>Wu, Anna H</creator><creator>Wang, Songren</creator><creator>Bookstein, Arthur</creator><creator>Le Marchand, Loïc</creator><creator>Wilkens, Lynne R</creator><creator>Haiman, Christopher A</creator><creator>Cheng, Iona</creator><creator>Monroe, Kristine R</creator><creator>Setiawan, Veronica Wendy</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9239-5692</orcidid><orcidid>https://orcid.org/0000-0002-3016-2081</orcidid><orcidid>https://orcid.org/0000-0002-6438-108X</orcidid><orcidid>https://orcid.org/0000-0001-5013-980X</orcidid><orcidid>https://orcid.org/0000-0001-8218-0401</orcidid></search><sort><creationdate>20220711</creationdate><title>Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort</title><author>Chen, Hongjie ; Wu, Anna H ; Wang, Songren ; Bookstein, Arthur ; Le Marchand, Loïc ; Wilkens, Lynne R ; Haiman, Christopher A ; Cheng, Iona ; Monroe, Kristine R ; Setiawan, Veronica Wendy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-2f6de5d662f361ffccac6cec90fe748942699b7c46d560ac0099e4eaa9c23cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Death</topic><topic>Editor's Choice</topic><topic>Health hazards</topic><topic>Health risks</topic><topic>Hispanic Americans</topic><topic>Hispanic or Latino</topic><topic>Humans</topic><topic>Immigrants</topic><topic>Lung cancer</topic><topic>Mexico - epidemiology</topic><topic>Minority & ethnic groups</topic><topic>Mortality</topic><topic>Mortality patterns</topic><topic>Neoplasms</topic><topic>Ovarian cancer</topic><topic>Parents & parenting</topic><topic>Residence Characteristics</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hongjie</creatorcontrib><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Wang, Songren</creatorcontrib><creatorcontrib>Bookstein, Arthur</creatorcontrib><creatorcontrib>Le Marchand, Loïc</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Haiman, Christopher A</creatorcontrib><creatorcontrib>Cheng, Iona</creatorcontrib><creatorcontrib>Monroe, Kristine R</creatorcontrib><creatorcontrib>Setiawan, Veronica Wendy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hongjie</au><au>Wu, Anna H</au><au>Wang, Songren</au><au>Bookstein, Arthur</au><au>Le Marchand, Loïc</au><au>Wilkens, Lynne R</au><au>Haiman, Christopher A</au><au>Cheng, Iona</au><au>Monroe, Kristine R</au><au>Setiawan, Veronica Wendy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>2022-07-11</date><risdate>2022</risdate><volume>114</volume><issue>7</issue><spage>959</spage><epage>968</epage><pages>959-968</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><abstract>Abstract
Background
Latinos are the largest minority group in the United States. We assessed cancer mortality by birthplace and generation status of Mexican Latinos in the Multiethnic Cohort.
Methods
We included 26 751 Latinos of Mexican origin and 6093 non-Latino Whites aged 45-74 years at cohort entry (1993-1996) from the California Multiethnic Cohort component. The Mexican Latinos comprised 42% first-generation Mexico-born immigrants, 42% second-generation (28% US-born with both parents Mexico-born and 14% US-born with 1 parent US-born and 1 parent Mexico-born), and 16% third-generation or more who were US-born with both parents US-born. Multivariable Cox models were used to calculate covariate adjusted hazard ratios and 95% confidence intervals for overall and site-specific cancer mortality by birthplace and generation status. All statistical tests were 2-sided.
Results
Cancer death rate was highest among the US-born with 1 parent US-born and 1 parent Mexico-born (age-adjusted rate = 471.0 per 100 000 person-years) and US-born with both parents US-born (age-adjusted rate = 469.0 per 100 000 person-years) groups. The US-born with both parents Mexico-born group had a 30% (hazard ratio = 1.30, 95% confidence interval = 1.18 to 1.44) higher risk of cancer death than the first-generation Mexico-born immigrants group, showing US birthplace was associated with an elevated cancer mortality. For cancer-specific mortality, US birthplace was positively associated with colorectal, liver and lung, and ovarian cancer (P values ranged from .04 to .005). Among US-born Mexican Latinos, generation status was not statistically significantly associated with overall cancer or site-specific cancer mortality.
Conclusions
Our findings suggest that US birthplace is a risk factor for cancer death in Mexican Americans. Identification of the contributing factors is important to curtail patterns of increasing cancer mortality in US-born Mexican Latinos.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>35404450</pmid><doi>10.1093/jnci/djac078</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9239-5692</orcidid><orcidid>https://orcid.org/0000-0002-3016-2081</orcidid><orcidid>https://orcid.org/0000-0002-6438-108X</orcidid><orcidid>https://orcid.org/0000-0001-5013-980X</orcidid><orcidid>https://orcid.org/0000-0001-8218-0401</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Cancer Cohort Studies Death Editor's Choice Health hazards Health risks Hispanic Americans Hispanic or Latino Humans Immigrants Lung cancer Mexico - epidemiology Minority & ethnic groups Mortality Mortality patterns Neoplasms Ovarian cancer Parents & parenting Residence Characteristics Risk analysis Risk factors Statistical analysis Statistical tests United States - epidemiology |
| title | Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort |
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