DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition

Idiopathic pulmonary fibrosis (IPF) is the most common chronic interstitial lung disease and is characterized by progressive scarring of the lung. Transforming growth factor-β (TGF-β) signaling plays an essential role in IPF and drives fibroblast to myofibroblast transition (FMT). Dedicator of cytok...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2022-07, Vol.323 (1), p.C133-C144
Hauptverfasser:	Guo, Xia, Adeyanju, Oluwaseun, Sunil, Christudas, Mandlem, Venkatakirankumar, Olajuyin, Ayobami, Huang, Steven, Chen, Shi-You, Idell, Steven, Tucker, Torry A, Qian, Guoqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - genetics Actins - metabolism Animals Bleomycin Bleomycin - toxicity Cells, Cultured Collagen Cytokinesis Disease Models, Animal Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Fibronectin Fibrosis GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Humans Idiopathic Pulmonary Fibrosis - chemically induced Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - physiopathology Interferon Lung - metabolism Lung - pathology Lung - physiopathology Lung diseases Metabolic pathways Mice Mice, Inbred C57BL Myofibroblasts - metabolism Myofibroblasts - pathology Pulmonary fibrosis Smad3 protein Smooth muscle Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factor-b
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