Uptake of oxidized lipids from the tumor microenvironment by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8 T cells

A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a feature associated with immune dysfunction. Here we examined how CD8 + tumor infiltrating lymphocytes (TILs) respond to lipids within the TME. We found elevated concentrations of several classes of lipids in t...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-06, Vol.54 (7), p.1561-1577.e7
Hauptverfasser:	Xu, Shihao, Chaudhary, Omkar, Rodríguez-Morales, Patricia, Sun, Xiaoli, Chen, Dan, Zappasodi, Roberta, Xu, Ziyan, Pinto, Antonio F. M., Williams, April, Schulze, Isabell, Farsakoglu, Yagmur, Varanasi, Siva Karthik, Low, Jun Siong, Tang, Wenxi, Wang, Haiping, McDonald, Bryan, Tripple, Victoria, Downes, Michael, Evans, Ronald M., Abumrad, Nada A., Merghoub, Taha, Wolchok, Jedd D., Shokhirev, Maxim N., Ho, Ping-Chih, Witztum, Joseph L., Emu, Brinda, Cui, Guoliang, Kaech, Susan M.
Format:	Artikel
Sprache:	eng
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