Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in a severe pneumonia associated with elevation of blood inflammatory parameters, reminiscent of cytokine storm syndrome. Steroidal anti-inflammatory therapies have shown efficacy in reducing mortality in critically il...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2022-10, Vol.150 (4), p.796-805
Hauptverfasser:	Bertoni, Arinna, Penco, Federica, Mollica, Hilaria, Bocca, Paola, Prigione, Ignazia, Corcione, Anna, Cangelosi, Davide, Schena, Francesca, Del Zotto, Genny, Amaro, Adriana, Paladino, Noemi, Pontali, Emanuele, Feasi, Marcello, Signa, Sara, Bustaffa, Marta, Caorsi, Roberta, Palmeri, Serena, Contini, Paola, De Palma, Raffaele, Pfeffer, Ulrich, Uva, Paolo, Rubartelli, Anna, Gattorno, Marco, Volpi, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents COVID-19 Drug Treatment Cytokine Release Syndrome - drug therapy Cytokines - metabolism DNA, Complementary Humans IL-1β Inflammasomes - metabolism inflammation Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-1beta - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLR Proteins NLRP3 inflammasome Receptors, Interleukin-1 SARS-CoV-2
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