Melatonin as an immunomodulator in children with Down syndrome

Background Down syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, increased oxidative stress, sleep disturbance and possibly abnormal endogenous melatonin levels. Melatonin has a myriad of immune functions, and we hypothesi...

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Veröffentlicht in:	Pediatric research 2022-06, Vol.91 (7), p.1812-1820
Hauptverfasser:	Huggard, Dean, Kelly, Lynne, Worrall, Amy, Gallagher, Eleanor, Fallah, Lida, Yoo, Lucas Lu, McGrane, Fiona, Lagan, Niamh, Roche, Edna, Balfe, Joanne, Doherty, Derek G., Molloy, Eleanor J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Child Clinical Clinical Research Article Cytokines Cytokines - metabolism Down syndrome Down Syndrome - drug therapy Humans Immunologic Factors Immunomodulators Inflammasomes Lipopolysaccharides - pharmacology Medicine Medicine & Public Health Melatonin Melatonin - pharmacology Melatonin - therapeutic use Myeloid Differentiation Factor 88 - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pediatric Surgery Pediatrics Toll-Like Receptor 4 - metabolism
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