Association between Dietary Anthocyanidins and Risk of Lung Cancer
Background: Anthocyanidins are a kind of water-soluble flavonoids widely found in flowers and fruits of many plants. Although the beneficial effect of anthocyanidins in cancer prevention has been discussed, the value of anthocyanidins in lung cancer prevention requires further investigation. In this...
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| Veröffentlicht in: | Nutrients 2022-06, Vol.14 (13), p.2643 |
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| creator | Zhang, Yin Zhu, Min Wan, Huajing Chen, Ling Luo, Fengming |
| description | Background: Anthocyanidins are a kind of water-soluble flavonoids widely found in flowers and fruits of many plants. Although the beneficial effect of anthocyanidins in cancer prevention has been discussed, the value of anthocyanidins in lung cancer prevention requires further investigation. In this study, we aimed to explore the role of dietary anthocyanidins in the prevention of lung cancer in population-based prospective studies. Methods: Data of participants in this study were collected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated in Cox proportional hazards regression for the association of dietary anthocyanidins and lung cancer risk. The dose-response relationship was explored between total anthocyanidins and the incidence of lung cancer. Results: A total of 97,993 participants were included in this study. The calculated HRs showed a trend that a higher quartile of total anthocyanidins indicated lower risk of lung cancer after adjusting for covariates (HRQ4vsQ1: 0.63; 95% CI: 0.55,0.73; p for trend < 0.001). A non-linear association between total anthocyanidins and lung cancer risk was found in the restricted cubic spline model. Conclusion: A protective association between dietary anthocyanidins and risk of lung cancer in Americans was investigated. |
| doi_str_mv | 10.3390/nu14132643 |
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Although the beneficial effect of anthocyanidins in cancer prevention has been discussed, the value of anthocyanidins in lung cancer prevention requires further investigation. In this study, we aimed to explore the role of dietary anthocyanidins in the prevention of lung cancer in population-based prospective studies. Methods: Data of participants in this study were collected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated in Cox proportional hazards regression for the association of dietary anthocyanidins and lung cancer risk. The dose-response relationship was explored between total anthocyanidins and the incidence of lung cancer. Results: A total of 97,993 participants were included in this study. The calculated HRs showed a trend that a higher quartile of total anthocyanidins indicated lower risk of lung cancer after adjusting for covariates (HRQ4vsQ1: 0.63; 95% CI: 0.55,0.73; p for trend < 0.001). A non-linear association between total anthocyanidins and lung cancer risk was found in the restricted cubic spline model. Conclusion: A protective association between dietary anthocyanidins and risk of lung cancer in Americans was investigated.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14132643</identifier><identifier>PMID: 35807824</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alcohol use ; Anthocyanin ; Anthocyanins ; Body mass index ; Cancer screening ; Confidence intervals ; Diet - adverse effects ; Disease prevention ; Ethnicity ; Family medical history ; Female ; Flavonoids ; Flowers ; Food ; Gender ; Health aspects ; Health risks ; Humans ; Kinases ; Lung cancer ; Lung Neoplasms - epidemiology ; Lung Neoplasms - etiology ; Lung Neoplasms - prevention & control ; Male ; Medical screening ; Nutrition research ; Ovarian cancer ; Plants (botany) ; Population studies ; Prevention ; Proportional Hazards Models ; Prospective Studies ; Prostate ; Questionnaires ; Risk ; Risk Factors ; Statistical analysis ; Trends ; Tumors ; United States ; Women</subject><ispartof>Nutrients, 2022-06, Vol.14 (13), p.2643</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-b449585d411618004ca95e3f436cc2b74b7d17602758464102627933a59a743</citedby><cites>FETCH-LOGICAL-c473t-b449585d411618004ca95e3f436cc2b74b7d17602758464102627933a59a743</cites><orcidid>0000-0001-9267-3437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268346/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268346/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35807824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yin</creatorcontrib><creatorcontrib>Zhu, Min</creatorcontrib><creatorcontrib>Wan, Huajing</creatorcontrib><creatorcontrib>Chen, Ling</creatorcontrib><creatorcontrib>Luo, Fengming</creatorcontrib><title>Association between Dietary Anthocyanidins and Risk of Lung Cancer</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Background: Anthocyanidins are a kind of water-soluble flavonoids widely found in flowers and fruits of many plants. Although the beneficial effect of anthocyanidins in cancer prevention has been discussed, the value of anthocyanidins in lung cancer prevention requires further investigation. In this study, we aimed to explore the role of dietary anthocyanidins in the prevention of lung cancer in population-based prospective studies. Methods: Data of participants in this study were collected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated in Cox proportional hazards regression for the association of dietary anthocyanidins and lung cancer risk. The dose-response relationship was explored between total anthocyanidins and the incidence of lung cancer. Results: A total of 97,993 participants were included in this study. The calculated HRs showed a trend that a higher quartile of total anthocyanidins indicated lower risk of lung cancer after adjusting for covariates (HRQ4vsQ1: 0.63; 95% CI: 0.55,0.73; p for trend < 0.001). A non-linear association between total anthocyanidins and lung cancer risk was found in the restricted cubic spline model. Conclusion: A protective association between dietary anthocyanidins and risk of lung cancer in Americans was investigated.</description><subject>Alcohol use</subject><subject>Anthocyanin</subject><subject>Anthocyanins</subject><subject>Body mass index</subject><subject>Cancer screening</subject><subject>Confidence intervals</subject><subject>Diet - adverse effects</subject><subject>Disease prevention</subject><subject>Ethnicity</subject><subject>Family medical history</subject><subject>Female</subject><subject>Flavonoids</subject><subject>Flowers</subject><subject>Food</subject><subject>Gender</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - prevention & control</subject><subject>Male</subject><subject>Medical screening</subject><subject>Nutrition research</subject><subject>Ovarian cancer</subject><subject>Plants (botany)</subject><subject>Population studies</subject><subject>Prevention</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Prostate</subject><subject>Questionnaires</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Statistical analysis</subject><subject>Trends</subject><subject>Tumors</subject><subject>United States</subject><subject>Women</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkVtLwzAYhoMoTqY3_gApeCPCZk7N194Icx5hIKj3IU3TLdol2rTK_r0pHqZicpGP5Pne5M2L0D7BY8ZyfOI6wgmjgrMNtEMx0JGI9eaPeoD2QnjE_QAMgm2jAUszDBnlO-hsEoLXVrXWu6Qw7ZsxLjm3plXNKpm4duH1SjlbWhcS5crkzoanxFfJrHPzZKqcNs0u2qpUHcze5zpE95cXD9Pr0ez26mY6mY00B9aOCs7zNEtLToggGcZcqzw1rOJMaE0L4AWUBASmkGZccIKpoJAzptJcAWdDdPqh-twVS1Nq49pG1fK5scv4VOmVlb9PnF3IuX-VORUZ4yIKHH0KNP6lM6GVSxu0qWvljO-CjBgAAU7ziB7-QR9917horqcEAUIysabmqjbSusrHe3UvKidAc4iuMxap8T9UnKVZWu2dqWzc_9Vw_NGgGx9CY6pvjwTLPnK5jjzCBz9_5Rv9Cpi9A7EXomE</recordid><startdate>20220626</startdate><enddate>20220626</enddate><creator>Zhang, Yin</creator><creator>Zhu, Min</creator><creator>Wan, Huajing</creator><creator>Chen, Ling</creator><creator>Luo, Fengming</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9267-3437</orcidid></search><sort><creationdate>20220626</creationdate><title>Association between Dietary Anthocyanidins and Risk of Lung Cancer</title><author>Zhang, Yin ; Zhu, Min ; Wan, Huajing ; Chen, Ling ; Luo, Fengming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-b449585d411618004ca95e3f436cc2b74b7d17602758464102627933a59a743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alcohol use</topic><topic>Anthocyanin</topic><topic>Anthocyanins</topic><topic>Body mass index</topic><topic>Cancer screening</topic><topic>Confidence intervals</topic><topic>Diet - adverse effects</topic><topic>Disease prevention</topic><topic>Ethnicity</topic><topic>Family medical history</topic><topic>Female</topic><topic>Flavonoids</topic><topic>Flowers</topic><topic>Food</topic><topic>Gender</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Kinases</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - prevention & control</topic><topic>Male</topic><topic>Medical screening</topic><topic>Nutrition research</topic><topic>Ovarian cancer</topic><topic>Plants (botany)</topic><topic>Population studies</topic><topic>Prevention</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Prostate</topic><topic>Questionnaires</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Statistical analysis</topic><topic>Trends</topic><topic>Tumors</topic><topic>United States</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yin</creatorcontrib><creatorcontrib>Zhu, Min</creatorcontrib><creatorcontrib>Wan, Huajing</creatorcontrib><creatorcontrib>Chen, Ling</creatorcontrib><creatorcontrib>Luo, Fengming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yin</au><au>Zhu, Min</au><au>Wan, Huajing</au><au>Chen, Ling</au><au>Luo, Fengming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Dietary Anthocyanidins and Risk of Lung Cancer</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2022-06-26</date><risdate>2022</risdate><volume>14</volume><issue>13</issue><spage>2643</spage><pages>2643-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Background: Anthocyanidins are a kind of water-soluble flavonoids widely found in flowers and fruits of many plants. Although the beneficial effect of anthocyanidins in cancer prevention has been discussed, the value of anthocyanidins in lung cancer prevention requires further investigation. In this study, we aimed to explore the role of dietary anthocyanidins in the prevention of lung cancer in population-based prospective studies. Methods: Data of participants in this study were collected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated in Cox proportional hazards regression for the association of dietary anthocyanidins and lung cancer risk. The dose-response relationship was explored between total anthocyanidins and the incidence of lung cancer. Results: A total of 97,993 participants were included in this study. The calculated HRs showed a trend that a higher quartile of total anthocyanidins indicated lower risk of lung cancer after adjusting for covariates (HRQ4vsQ1: 0.63; 95% CI: 0.55,0.73; p for trend < 0.001). A non-linear association between total anthocyanidins and lung cancer risk was found in the restricted cubic spline model. Conclusion: A protective association between dietary anthocyanidins and risk of lung cancer in Americans was investigated.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35807824</pmid><doi>10.3390/nu14132643</doi><orcidid>https://orcid.org/0000-0001-9267-3437</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol use Anthocyanin Anthocyanins Body mass index Cancer screening Confidence intervals Diet - adverse effects Disease prevention Ethnicity Family medical history Female Flavonoids Flowers Food Gender Health aspects Health risks Humans Kinases Lung cancer Lung Neoplasms - epidemiology Lung Neoplasms - etiology Lung Neoplasms - prevention & control Male Medical screening Nutrition research Ovarian cancer Plants (botany) Population studies Prevention Proportional Hazards Models Prospective Studies Prostate Questionnaires Risk Risk Factors Statistical analysis Trends Tumors United States Women |
| title | Association between Dietary Anthocyanidins and Risk of Lung Cancer |
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