Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study
Background: Some research indicated that hypothyroidism has huge adverse effects for the metabolic, cardiovascular, respiratory, and immune systems. However, there is no confirmed conclusion for the effect of cardiovascular surgery. This cohort study aims to investigate the prognosis of hypothyroidi...
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Veröffentlicht in: | Journal of clinical medicine 2022-07, Vol.11 (13), p.3881 |
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creator | Lin, Jiun-Yu Kao, Pei-Chi Tsai, Yi-Ting Chung, Chi-Hsiang Chien, Wu-Chien Lin, Chih-Yuan Lu, Chieh-Hua Tsai, Chien-Sung |
description | Background: Some research indicated that hypothyroidism has huge adverse effects for the metabolic, cardiovascular, respiratory, and immune systems. However, there is no confirmed conclusion for the effect of cardiovascular surgery. This cohort study aims to investigate the prognosis of hypothyroidism patient at the age under 65-year-old after coronary artery bypass grafting (CABG) surgery. Method: From the National Health Insurance Research Database of Taiwan, 1586 patients with hypothyroidism who underwent elective CABG surgery were selected, along with 6334 patients who underwent surgery in a ratio of 1:4 sex-, age- and index year-matched controls, who were out of hypothyroidism. We used Cox proportional hazard analysis to compare the rate of 30-day, 5-year mortality, post-operative atrial fibrillation, respiratory complication during an average of 10-year follow-up. Result: Post-CABG patients had more hospital days, which was associated with hypothyroidism, male, DM and higher CCI_R (p < 0.001). Post-CABG patients had more inpatient respiratory complications, which was associated with hypothyroidism (p = 0.041), DM and CCI_R (p < 0.001, p = 0.046), and there was no difference in 1-year respiratory complication, tracheostomy in the same hospital course and within 1 year, repeated PCI, Af, CVVH, cerebral infarction, 30-day and 5-year mortality rate. Conclusions: Hypothyroidism correlates to post-CABG ventilator-related complications and pneumonia, and prolonged hospital days, but no effect on 30-day, 5-year mortality, post-operative atrial fibrillation and cerebral infarction rate. Thyroid function survey might include routinely preoperative survey for CABG outcome prognosis. |
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fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9267490</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2686027946</sourcerecordid><originalsourceid>FETCH-LOGICAL-c367t-292fe07d53ec9f859fee5a393734f4d12c5ce86d32db1ed2e7808566097d44f53</originalsourceid><addsrcrecordid>eNpdkk1v1DAQhiMEolXpiTuyxAUJAv5IYocD0nZbupVWgCggcbLceLLrVWIH22mVf8jPwmlLteCLZ_w-emfGmix7TvBbxmr8btf0hBDGhCCPskOKOc8xE-zxXnyQHYeww-kIUVDCn2YHrBSYk0ocZr9X0-DidvLOaBN6dBHQ0nkPnYqg0Y2JW_QDbDQpdz5J_dCZRkXjbEDKarR2dgMerVwYTFQdOlVTEtoIM-ydVX5CC5_SCZ1MgwoBnfskG7tBl6PfzO_GIoW-zhXNNXQT-unGpH5xw9jdFnqPFujTbXRjNLzZU_ITFVKXl3HU07PsSau6AMf391H2_ePZt-UqX38-v1gu1nnDKh5zWtMWMNclg6ZuRVm3AKViNeOsaAtNaFM2ICrNqL4ioClwgUVZVbjmuijakh1lH-58h_GqB92kz_Gqk4M3fZpVOmXkv4o1W7lx17KmFS9qnAxe3Rt492uEEGVvQgNdpyy4MUhaCc5pWTKa0Jf_oTs3epvGm6kKU14XVaJe31GNdyF4aB-aIVjOSyL3liTRL_b7f2D_rgT7A2nyvKY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2686027946</pqid></control><display><type>article</type><title>Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Lin, Jiun-Yu ; Kao, Pei-Chi ; Tsai, Yi-Ting ; Chung, Chi-Hsiang ; Chien, Wu-Chien ; Lin, Chih-Yuan ; Lu, Chieh-Hua ; Tsai, Chien-Sung</creator><creatorcontrib>Lin, Jiun-Yu ; Kao, Pei-Chi ; Tsai, Yi-Ting ; Chung, Chi-Hsiang ; Chien, Wu-Chien ; Lin, Chih-Yuan ; Lu, Chieh-Hua ; Tsai, Chien-Sung</creatorcontrib><description>Background: Some research indicated that hypothyroidism has huge adverse effects for the metabolic, cardiovascular, respiratory, and immune systems. However, there is no confirmed conclusion for the effect of cardiovascular surgery. This cohort study aims to investigate the prognosis of hypothyroidism patient at the age under 65-year-old after coronary artery bypass grafting (CABG) surgery. Method: From the National Health Insurance Research Database of Taiwan, 1586 patients with hypothyroidism who underwent elective CABG surgery were selected, along with 6334 patients who underwent surgery in a ratio of 1:4 sex-, age- and index year-matched controls, who were out of hypothyroidism. We used Cox proportional hazard analysis to compare the rate of 30-day, 5-year mortality, post-operative atrial fibrillation, respiratory complication during an average of 10-year follow-up. Result: Post-CABG patients had more hospital days, which was associated with hypothyroidism, male, DM and higher CCI_R (p < 0.001). Post-CABG patients had more inpatient respiratory complications, which was associated with hypothyroidism (p = 0.041), DM and CCI_R (p < 0.001, p = 0.046), and there was no difference in 1-year respiratory complication, tracheostomy in the same hospital course and within 1 year, repeated PCI, Af, CVVH, cerebral infarction, 30-day and 5-year mortality rate. Conclusions: Hypothyroidism correlates to post-CABG ventilator-related complications and pneumonia, and prolonged hospital days, but no effect on 30-day, 5-year mortality, post-operative atrial fibrillation and cerebral infarction rate. Thyroid function survey might include routinely preoperative survey for CABG outcome prognosis.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11133881</identifier><identifier>PMID: 35807168</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Cardiac arrhythmia ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Clinical medicine ; Comorbidity ; Coronary vessels ; Health insurance ; Heart surgery ; Hospitalization ; Hypothyroidism ; Laboratories ; Mortality ; Ostomy ; Patients ; Pneumonia ; Population ; Population-based studies ; Regression analysis ; Review boards ; Statistical analysis ; Thyroid gland ; Tracheotomy ; Urbanization ; Ventilators</subject><ispartof>Journal of clinical medicine, 2022-07, Vol.11 (13), p.3881</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c367t-292fe07d53ec9f859fee5a393734f4d12c5ce86d32db1ed2e7808566097d44f53</cites><orcidid>0000-0002-4576-9900 ; 0000-0002-2179-9486 ; 0000-0002-3286-0780</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267490/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267490/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35807168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Jiun-Yu</creatorcontrib><creatorcontrib>Kao, Pei-Chi</creatorcontrib><creatorcontrib>Tsai, Yi-Ting</creatorcontrib><creatorcontrib>Chung, Chi-Hsiang</creatorcontrib><creatorcontrib>Chien, Wu-Chien</creatorcontrib><creatorcontrib>Lin, Chih-Yuan</creatorcontrib><creatorcontrib>Lu, Chieh-Hua</creatorcontrib><creatorcontrib>Tsai, Chien-Sung</creatorcontrib><title>Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Background: Some research indicated that hypothyroidism has huge adverse effects for the metabolic, cardiovascular, respiratory, and immune systems. However, there is no confirmed conclusion for the effect of cardiovascular surgery. This cohort study aims to investigate the prognosis of hypothyroidism patient at the age under 65-year-old after coronary artery bypass grafting (CABG) surgery. Method: From the National Health Insurance Research Database of Taiwan, 1586 patients with hypothyroidism who underwent elective CABG surgery were selected, along with 6334 patients who underwent surgery in a ratio of 1:4 sex-, age- and index year-matched controls, who were out of hypothyroidism. We used Cox proportional hazard analysis to compare the rate of 30-day, 5-year mortality, post-operative atrial fibrillation, respiratory complication during an average of 10-year follow-up. Result: Post-CABG patients had more hospital days, which was associated with hypothyroidism, male, DM and higher CCI_R (p < 0.001). Post-CABG patients had more inpatient respiratory complications, which was associated with hypothyroidism (p = 0.041), DM and CCI_R (p < 0.001, p = 0.046), and there was no difference in 1-year respiratory complication, tracheostomy in the same hospital course and within 1 year, repeated PCI, Af, CVVH, cerebral infarction, 30-day and 5-year mortality rate. Conclusions: Hypothyroidism correlates to post-CABG ventilator-related complications and pneumonia, and prolonged hospital days, but no effect on 30-day, 5-year mortality, post-operative atrial fibrillation and cerebral infarction rate. Thyroid function survey might include routinely preoperative survey for CABG outcome prognosis.</description><subject>Age</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical medicine</subject><subject>Comorbidity</subject><subject>Coronary vessels</subject><subject>Health insurance</subject><subject>Heart surgery</subject><subject>Hospitalization</subject><subject>Hypothyroidism</subject><subject>Laboratories</subject><subject>Mortality</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Population</subject><subject>Population-based studies</subject><subject>Regression analysis</subject><subject>Review boards</subject><subject>Statistical analysis</subject><subject>Thyroid gland</subject><subject>Tracheotomy</subject><subject>Urbanization</subject><subject>Ventilators</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkk1v1DAQhiMEolXpiTuyxAUJAv5IYocD0nZbupVWgCggcbLceLLrVWIH22mVf8jPwmlLteCLZ_w-emfGmix7TvBbxmr8btf0hBDGhCCPskOKOc8xE-zxXnyQHYeww-kIUVDCn2YHrBSYk0ocZr9X0-DidvLOaBN6dBHQ0nkPnYqg0Y2JW_QDbDQpdz5J_dCZRkXjbEDKarR2dgMerVwYTFQdOlVTEtoIM-ydVX5CC5_SCZ1MgwoBnfskG7tBl6PfzO_GIoW-zhXNNXQT-unGpH5xw9jdFnqPFujTbXRjNLzZU_ITFVKXl3HU07PsSau6AMf391H2_ePZt-UqX38-v1gu1nnDKh5zWtMWMNclg6ZuRVm3AKViNeOsaAtNaFM2ICrNqL4ioClwgUVZVbjmuijakh1lH-58h_GqB92kz_Gqk4M3fZpVOmXkv4o1W7lx17KmFS9qnAxe3Rt492uEEGVvQgNdpyy4MUhaCc5pWTKa0Jf_oTs3epvGm6kKU14XVaJe31GNdyF4aB-aIVjOSyL3liTRL_b7f2D_rgT7A2nyvKY</recordid><startdate>20220704</startdate><enddate>20220704</enddate><creator>Lin, Jiun-Yu</creator><creator>Kao, Pei-Chi</creator><creator>Tsai, Yi-Ting</creator><creator>Chung, Chi-Hsiang</creator><creator>Chien, Wu-Chien</creator><creator>Lin, Chih-Yuan</creator><creator>Lu, Chieh-Hua</creator><creator>Tsai, Chien-Sung</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4576-9900</orcidid><orcidid>https://orcid.org/0000-0002-2179-9486</orcidid><orcidid>https://orcid.org/0000-0002-3286-0780</orcidid></search><sort><creationdate>20220704</creationdate><title>Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study</title><author>Lin, Jiun-Yu ; Kao, Pei-Chi ; Tsai, Yi-Ting ; Chung, Chi-Hsiang ; Chien, Wu-Chien ; Lin, Chih-Yuan ; Lu, Chieh-Hua ; Tsai, Chien-Sung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-292fe07d53ec9f859fee5a393734f4d12c5ce86d32db1ed2e7808566097d44f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical medicine</topic><topic>Comorbidity</topic><topic>Coronary vessels</topic><topic>Health insurance</topic><topic>Heart surgery</topic><topic>Hospitalization</topic><topic>Hypothyroidism</topic><topic>Laboratories</topic><topic>Mortality</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Population</topic><topic>Population-based studies</topic><topic>Regression analysis</topic><topic>Review boards</topic><topic>Statistical analysis</topic><topic>Thyroid gland</topic><topic>Tracheotomy</topic><topic>Urbanization</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Jiun-Yu</creatorcontrib><creatorcontrib>Kao, Pei-Chi</creatorcontrib><creatorcontrib>Tsai, Yi-Ting</creatorcontrib><creatorcontrib>Chung, Chi-Hsiang</creatorcontrib><creatorcontrib>Chien, Wu-Chien</creatorcontrib><creatorcontrib>Lin, Chih-Yuan</creatorcontrib><creatorcontrib>Lu, Chieh-Hua</creatorcontrib><creatorcontrib>Tsai, Chien-Sung</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Jiun-Yu</au><au>Kao, Pei-Chi</au><au>Tsai, Yi-Ting</au><au>Chung, Chi-Hsiang</au><au>Chien, Wu-Chien</au><au>Lin, Chih-Yuan</au><au>Lu, Chieh-Hua</au><au>Tsai, Chien-Sung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-07-04</date><risdate>2022</risdate><volume>11</volume><issue>13</issue><spage>3881</spage><pages>3881-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: Some research indicated that hypothyroidism has huge adverse effects for the metabolic, cardiovascular, respiratory, and immune systems. However, there is no confirmed conclusion for the effect of cardiovascular surgery. This cohort study aims to investigate the prognosis of hypothyroidism patient at the age under 65-year-old after coronary artery bypass grafting (CABG) surgery. Method: From the National Health Insurance Research Database of Taiwan, 1586 patients with hypothyroidism who underwent elective CABG surgery were selected, along with 6334 patients who underwent surgery in a ratio of 1:4 sex-, age- and index year-matched controls, who were out of hypothyroidism. We used Cox proportional hazard analysis to compare the rate of 30-day, 5-year mortality, post-operative atrial fibrillation, respiratory complication during an average of 10-year follow-up. Result: Post-CABG patients had more hospital days, which was associated with hypothyroidism, male, DM and higher CCI_R (p < 0.001). Post-CABG patients had more inpatient respiratory complications, which was associated with hypothyroidism (p = 0.041), DM and CCI_R (p < 0.001, p = 0.046), and there was no difference in 1-year respiratory complication, tracheostomy in the same hospital course and within 1 year, repeated PCI, Af, CVVH, cerebral infarction, 30-day and 5-year mortality rate. Conclusions: Hypothyroidism correlates to post-CABG ventilator-related complications and pneumonia, and prolonged hospital days, but no effect on 30-day, 5-year mortality, post-operative atrial fibrillation and cerebral infarction rate. Thyroid function survey might include routinely preoperative survey for CABG outcome prognosis.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35807168</pmid><doi>10.3390/jcm11133881</doi><orcidid>https://orcid.org/0000-0002-4576-9900</orcidid><orcidid>https://orcid.org/0000-0002-2179-9486</orcidid><orcidid>https://orcid.org/0000-0002-3286-0780</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age Cardiac arrhythmia Cardiovascular disease Chronic obstructive pulmonary disease Clinical medicine Comorbidity Coronary vessels Health insurance Heart surgery Hospitalization Hypothyroidism Laboratories Mortality Ostomy Patients Pneumonia Population Population-based studies Regression analysis Review boards Statistical analysis Thyroid gland Tracheotomy Urbanization Ventilators |
title | Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study |
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