Methylphenidate Restores Behavioral and Neuroplasticity Impairments in the Prenatal Nicotine Exposure Mouse Model of ADHD: Evidence for Involvement of AMPA Receptor Subunit Composition and Synaptic Spine Morphology in the Hippocampus

In ADHD treatment, methylphenidate (MPH) is the most frequently used medication. The present work provides evidence that MPH restored behavioral impairments and neuroplasticity due to changes in AMPAR subunit composition and distribution, as well as maturation of dendritic spines, in a prenatal nico...

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Veröffentlicht in:	International journal of molecular sciences 2022-07, Vol.23 (13), p.7099
Hauptverfasser:	Contreras, Darwin, Piña, Ricardo, Carvallo, Claudia, Godoy, Felipe, Ugarte, Gonzalo, Zeise, Marc, Rozas, Carlos, Morales, Bernardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Attention deficit hyperactivity disorder Behavior Behavioral plasticity Cell surface Composition Crosslinking Dendritic spines Dendritic structure Excitatory postsynaptic potentials Hippocampus Hyperactivity Impulsivity Long-term potentiation Methylphenidate Morphology Neuroplasticity Nicotine Phosphorylation Prenatal experience Pyramidal cells Short term memory Subunit structure Synapses Western blotting α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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