The Mafb cleft‐associated variant H131Q is not required for palatogenesis in the mouse

Background Orofacial clefts (OFCs) are common birth defects with complex etiology. Genome wide association studies for OFC have identified SNPs in and near MAFB. MAFB is a transcription factor critical for structural development of digits, kidneys, skin, and brain. MAFB is also expressed in the cran...

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Veröffentlicht in:	Developmental dynamics 2021-10, Vol.250 (10), p.1463-1476
Hauptverfasser:	Paul, Brian J., Palmer, Kristina J., Rhea, Lindsey, Carlson, Melissa, Sharp, Jocelyn C., Pratt, C. Herbert, Murray, Stephen A., Dunnwald, Martine
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Animals Birth defects Cleft Palate - genetics Cleft Palate - metabolism Congenital defects craniofacial development Embryos Epithelial cells Epithelium Etiology Genetic Predisposition to Disease Genome-wide association studies Genomes Keratin Kidneys Mafb MafB Transcription Factor - genetics MafB Transcription Factor - metabolism Mesenchyme Mice Mice, Transgenic Morphogenesis mouse mutation Orofacial clefts Palate - embryology Palate - metabolism Polymorphism, Single Nucleotide
Online-Zugang:	Volltext
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