Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain

Methadone (MTD) is a commonly prescribed treatment for opioid use disorder in pregnancy, despite limited information on the effects of passive exposure on fetal brain development. Animal studies suggest a link between perinatal MTD exposure and impaired white matter development. In this study, we ch...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2022-06, Vol.247 (12), p.1067-1079
Hauptverfasser:	Gibson, Jennifer M, Chu, Tianci, Zeng, Wenxin, Wethall, Ashley C, Kong, Maiying, Mellen, Nicholas, Devlin Phinney, Lori A, Cai, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Brain Female Male Methadone - pharmacology Myelin Sheath Oligodendroglia Original Research Pregnancy Rats Rats, Sprague-Dawley
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